IPNA Pediatric Nephrology
@ped-neph.bsky.social
Original clinical research and reviews on all aspects of acute and chronic diseases affecting kidney function in children. Official journal of IPNA.
A 3-yr-old boy presented w/dark-colored urine for 4 months. His history was negative for infections; he was taking oral methylcobalamin treatment for a persistent deficiency. Read these Clinical Insights into a case of Imerslund-Gräsbeck syndrome.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 26, 2025 at 7:26 PM
A 3-yr-old boy presented w/dark-colored urine for 4 months. His history was negative for infections; he was taking oral methylcobalamin treatment for a persistent deficiency. Read these Clinical Insights into a case of Imerslund-Gräsbeck syndrome.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
B-cell-depleting agents like rituximab (RTX) treat severe steroid-dependent idiopathic nephrotic syndrome (SDNS) & frequent relapses. Read this Original Article on obinutuzumab as an option for SDNS children resistant to RTX w/anti-RTX antibodies.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 26, 2025 at 7:10 PM
B-cell-depleting agents like rituximab (RTX) treat severe steroid-dependent idiopathic nephrotic syndrome (SDNS) & frequent relapses. Read this Original Article on obinutuzumab as an option for SDNS children resistant to RTX w/anti-RTX antibodies.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
As a rare autosomal recessive disorder, primary hyperoxaluria type 3 (PH3) presents diagnostic challenges. Read this Original Article comparing clinical characteristics of Chinese children w/PH3 and non-PH.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 25, 2025 at 7:36 PM
As a rare autosomal recessive disorder, primary hyperoxaluria type 3 (PH3) presents diagnostic challenges. Read this Original Article comparing clinical characteristics of Chinese children w/PH3 and non-PH.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
The renin–angiotensin–aldosterone system is essential for BP regulation, & its absence in children w/bilateral kidney loss predisposes them to hypotension. Read this Original Article on prolonged hypotension in children w/bilateral kidney absence.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 25, 2025 at 7:18 PM
The renin–angiotensin–aldosterone system is essential for BP regulation, & its absence in children w/bilateral kidney loss predisposes them to hypotension. Read this Original Article on prolonged hypotension in children w/bilateral kidney absence.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Urinary pH influence solubility & excretion of lithogenic substances, yet its relationship w/other metabolic parameters is underexplored. Read this Original Article on impact of urine pH on lithogenic risk profile in children w/urolithiasis. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 24, 2025 at 7:39 PM
Urinary pH influence solubility & excretion of lithogenic substances, yet its relationship w/other metabolic parameters is underexplored. Read this Original Article on impact of urine pH on lithogenic risk profile in children w/urolithiasis. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Neonatal AKI affects approx 1/3 of newborns admitted to neonatal ICUs & is associated w/increased morbidity & mortality. Read this Review of neonatal AKI: where are we now?
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 24, 2025 at 7:19 PM
Neonatal AKI affects approx 1/3 of newborns admitted to neonatal ICUs & is associated w/increased morbidity & mortality. Read this Review of neonatal AKI: where are we now?
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Pediatric AKI is commonly staged by pRIFLE, which uses estimated glomerular filtration rate from creatinine & cystatin C. Read this Research Letter on biomarker kinetics & early underestimation of AKI severity by pRIFLE.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 21, 2025 at 5:56 PM
Pediatric AKI is commonly staged by pRIFLE, which uses estimated glomerular filtration rate from creatinine & cystatin C. Read this Research Letter on biomarker kinetics & early underestimation of AKI severity by pRIFLE.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Varicella zoster (VZV) vaccination pre-kidney transplant (Tx) can help prevent severe disseminated VZV in immunosuppressed recipients. Read this Original Article on risk factors for loss of Varicella immunity after pediatric Tx. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 21, 2025 at 5:42 PM
Varicella zoster (VZV) vaccination pre-kidney transplant (Tx) can help prevent severe disseminated VZV in immunosuppressed recipients. Read this Original Article on risk factors for loss of Varicella immunity after pediatric Tx. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Pediatric nephrolithiasis is increasing globally, w/hematuria being one of its most frequent diagnostic markers. Read this Original Article on hematuria as a diagnostic marker in pediatric nephrolithiasis w/o acute obstruction or infection.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 20, 2025 at 6:40 PM
Pediatric nephrolithiasis is increasing globally, w/hematuria being one of its most frequent diagnostic markers. Read this Original Article on hematuria as a diagnostic marker in pediatric nephrolithiasis w/o acute obstruction or infection.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
IgA nephropathy (IgAN) is a common glomerular disease in children that may progress to CKD & kidney failure. Read this Original Article on prognosis & predictive factors in pediatric IgAN. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 20, 2025 at 6:28 PM
IgA nephropathy (IgAN) is a common glomerular disease in children that may progress to CKD & kidney failure. Read this Original Article on prognosis & predictive factors in pediatric IgAN. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Congenital lower urinary tract obstruction (cLUTO) describes a heterogeneous spectrum of congenital lower urinary tract defects w/variable postnatal outcomes. Read this Review of early diagnosis & intervention in cLUTO. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 19, 2025 at 7:35 PM
Congenital lower urinary tract obstruction (cLUTO) describes a heterogeneous spectrum of congenital lower urinary tract defects w/variable postnatal outcomes. Read this Review of early diagnosis & intervention in cLUTO. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Read this Original Article on changes in maintenance immunosuppression after pediatric kidney transplantation: a report from the Nordic pediatric kidney transplantation registry. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 19, 2025 at 7:15 PM
Read this Original Article on changes in maintenance immunosuppression after pediatric kidney transplantation: a report from the Nordic pediatric kidney transplantation registry. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
CKD has unique clinical characteristics in the pediatric population, including growth disturbances & alterations in neurocognitive development. Read this Systematic Review /Meta-analysis of association between CKD & neurodevelopmental outcomes in childhood.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 18, 2025 at 6:50 PM
CKD has unique clinical characteristics in the pediatric population, including growth disturbances & alterations in neurocognitive development. Read this Systematic Review /Meta-analysis of association between CKD & neurodevelopmental outcomes in childhood.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
There are few reports on complications of pediatric kidney biopsy, & no comparative studies between open kidney biopsy (OB) & percutaneous needle kidney biopsy in pediatric populations. Read this Original Article on safety & utility of OB in children.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 18, 2025 at 6:39 PM
There are few reports on complications of pediatric kidney biopsy, & no comparative studies between open kidney biopsy (OB) & percutaneous needle kidney biopsy in pediatric populations. Read this Original Article on safety & utility of OB in children.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Recent studies indicate that telitacicept significantly diminishes proteinuria levels in adult patients diagnosed w/IgA nephropathy (IgAN). Read this Original Article on efficacy & safety of telitacicept in treating pediatric IgAN.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 17, 2025 at 6:18 PM
Recent studies indicate that telitacicept significantly diminishes proteinuria levels in adult patients diagnosed w/IgA nephropathy (IgAN). Read this Original Article on efficacy & safety of telitacicept in treating pediatric IgAN.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
GFR can be measured directly, or estimated from biomarkers like serum creatinine & cystatin C, or both. Measuring GFR in children is cumbersome. Read this Review of measuring & estimating GFR in children: state of the art in 2025. Free access this month.
bit.ly/47meymz
bit.ly/47meymz
November 17, 2025 at 6:03 PM
GFR can be measured directly, or estimated from biomarkers like serum creatinine & cystatin C, or both. Measuring GFR in children is cumbersome. Read this Review of measuring & estimating GFR in children: state of the art in 2025. Free access this month.
bit.ly/47meymz
bit.ly/47meymz
Nephrotoxic medication (NTMx) exposure can cause hospital-acquired AKI in non-critically ill, hospitalized children. Read this Original Article on differences in NTMx exposure & AKI in pediatric bone marrow transplant, oncology, & pulmonary service lines.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 14, 2025 at 7:32 PM
Nephrotoxic medication (NTMx) exposure can cause hospital-acquired AKI in non-critically ill, hospitalized children. Read this Original Article on differences in NTMx exposure & AKI in pediatric bone marrow transplant, oncology, & pulmonary service lines.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Autosomal dominant tubulointerstitial kidney disease (ADTKD-UMOD) typically presents w/elevated serum creatinine & gout between the 2nd & 4th decades of life. Read these Clinical Insights into UMOD-associated AKTKD-UMOD in a pediatric patient. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 14, 2025 at 7:13 PM
Autosomal dominant tubulointerstitial kidney disease (ADTKD-UMOD) typically presents w/elevated serum creatinine & gout between the 2nd & 4th decades of life. Read these Clinical Insights into UMOD-associated AKTKD-UMOD in a pediatric patient. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Renal tubular dysgenesis is characterized by impaired development of the proximal tubules & kidney dysfunction. Read these Clinical Insights into long-term kidney function stabilization w/fludrocortisone in autosomal recessive renal tubular dysgenesis.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 14, 2025 at 12:05 AM
Renal tubular dysgenesis is characterized by impaired development of the proximal tubules & kidney dysfunction. Read these Clinical Insights into long-term kidney function stabilization w/fludrocortisone in autosomal recessive renal tubular dysgenesis.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Immunosuppressive drugs are required for childhood FRNS, SDNS, & SRNS. Read this Original Article on remission rates & long-term outcomes of relapsed pediatric NS: cyclophosphamide vs. cyclosporin A.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 13, 2025 at 11:42 PM
Immunosuppressive drugs are required for childhood FRNS, SDNS, & SRNS. Read this Original Article on remission rates & long-term outcomes of relapsed pediatric NS: cyclophosphamide vs. cyclosporin A.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Pediatric solid organ transplantation recipients are at increased risk of diarrhea due to immunosuppression & epidemiological risk factors. Read this Research Letter re oral immunoglobulin for norovirus diarrhea in pediatric kidney transplant recipients.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 12, 2025 at 7:15 PM
Pediatric solid organ transplantation recipients are at increased risk of diarrhea due to immunosuppression & epidemiological risk factors. Read this Research Letter re oral immunoglobulin for norovirus diarrhea in pediatric kidney transplant recipients.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Nephrolithiasis (NL) & nephrocalcinosis (NC) are common pediatric kidney conditions globally. Read this Original Article on genetic causes of NL & NC in a pediatric population in Saudi Arabia. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 12, 2025 at 6:54 PM
Nephrolithiasis (NL) & nephrocalcinosis (NC) are common pediatric kidney conditions globally. Read this Original Article on genetic causes of NL & NC in a pediatric population in Saudi Arabia. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Rituximab is a therapeutic option in children w/refractory nephrotic syndrome (RNS), but the efficacy & safety of rituximab treatment remain unclear. Read this Systematic Review /Meta-analysis of rituximab efficacy in pediatric RNS. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 10, 2025 at 10:23 PM
Rituximab is a therapeutic option in children w/refractory nephrotic syndrome (RNS), but the efficacy & safety of rituximab treatment remain unclear. Read this Systematic Review /Meta-analysis of rituximab efficacy in pediatric RNS. Open Access
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Hypernatremia is a challenging condition. A rapid increase in blood sodium can draw water out of brain cells. A rapid correction to a slow increase can cause cerebral swelling. Read this Editorial Commentary on thirst, sodium & the hospitalized child.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 7, 2025 at 7:26 PM
Hypernatremia is a challenging condition. A rapid increase in blood sodium can draw water out of brain cells. A rapid correction to a slow increase can cause cerebral swelling. Read this Editorial Commentary on thirst, sodium & the hospitalized child.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
CKD is in WHO’s noncommunicable diseases prevention program to reduce premature mortality by 33% by 2030. There are stark regional differences in CKD burden that disproportionally affects low-income countries. Read this Editorial Commentary on CKDu in children.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 6, 2025 at 6:19 PM
CKD is in WHO’s noncommunicable diseases prevention program to reduce premature mortality by 33% by 2030. There are stark regional differences in CKD burden that disproportionally affects low-income countries. Read this Editorial Commentary on CKDu in children.
link.springer.com/article/10.1...
link.springer.com/article/10.1...