Paul Robustelli
@paulrobustelli.bsky.social
Assistant Professor at Dartmouth College
Computational Biophysics / Disordered Proteins / Molecular Recognition
Computational Biophysics / Disordered Proteins / Molecular Recognition
Lets look at 1aa ternary complexes to see what we're talking about.
Ligands tend to bind at one dominant interface, engage aromatic side chains and induce helix folding, but do so with a collection of fuzzy(ish) binding modes. We feel this matches the magnitude of NMR CSPs in experiments well
Ligands tend to bind at one dominant interface, engage aromatic side chains and induce helix folding, but do so with a collection of fuzzy(ish) binding modes. We feel this matches the magnitude of NMR CSPs in experiments well
November 22, 2025 at 7:11 PM
Lets look at 1aa ternary complexes to see what we're talking about.
Ligands tend to bind at one dominant interface, engage aromatic side chains and induce helix folding, but do so with a collection of fuzzy(ish) binding modes. We feel this matches the magnitude of NMR CSPs in experiments well
Ligands tend to bind at one dominant interface, engage aromatic side chains and induce helix folding, but do so with a collection of fuzzy(ish) binding modes. We feel this matches the magnitude of NMR CSPs in experiments well
Proud to share our manuscript:
"How small molecules stabilize oligomers of a phase-separating disordered protein"
www.biorxiv.org/content/10.1...
by Jiaqi Zhu and Tommy Sisk, in collaboration with @borjaml.bsky.social , Stase Bielskute-Garcia & @xsalvatella1.bsky.social
"How small molecules stabilize oligomers of a phase-separating disordered protein"
www.biorxiv.org/content/10.1...
by Jiaqi Zhu and Tommy Sisk, in collaboration with @borjaml.bsky.social , Stase Bielskute-Garcia & @xsalvatella1.bsky.social
November 22, 2025 at 7:11 PM
Proud to share our manuscript:
"How small molecules stabilize oligomers of a phase-separating disordered protein"
www.biorxiv.org/content/10.1...
by Jiaqi Zhu and Tommy Sisk, in collaboration with @borjaml.bsky.social , Stase Bielskute-Garcia & @xsalvatella1.bsky.social
"How small molecules stabilize oligomers of a phase-separating disordered protein"
www.biorxiv.org/content/10.1...
by Jiaqi Zhu and Tommy Sisk, in collaboration with @borjaml.bsky.social , Stase Bielskute-Garcia & @xsalvatella1.bsky.social
Interestingly, the exposed regions of YX-A-1 are quite hydrophobic (cylcohexane and benzene) - and we think this could be part of how it accelerates aggregation into higher order oligomers and protofilaments
September 27, 2025 at 1:45 PM
Interestingly, the exposed regions of YX-A-1 are quite hydrophobic (cylcohexane and benzene) - and we think this could be part of how it accelerates aggregation into higher order oligomers and protofilaments