Parallel Squared Technology Institute
@parallelsq.bsky.social
A nonprofit research institute for advancing protein research in human health and disease | parallelsq.org
Technologies for increasing the parallelization of mass spectrometry proteomics in the time and mass domains:
www.parallelsq.org/research-ove...
www.parallelsq.org/research-ove...
Research Overview - PTI - Parallel Squared Technology Institute
Parallel Squared Technology Institute is a non-profit research institute that’s scaling up proteomics to illuminate the link between protein patterns, functional interactions, and disease.
www.parallelsq.org
November 20, 2025 at 2:53 PM
Technologies for increasing the parallelization of mass spectrometry proteomics in the time and mass domains:
www.parallelsq.org/research-ove...
www.parallelsq.org/research-ove...
We aim to enable this via plexDIA and new mass tags:
www.parallelsq.org/psmtags
They bring multiplexed, high-throughput DIA to map these changes across population scale cohorts, including protein PTMs and single-cell proteomes.
www.parallelsq.org/psmtags
They bring multiplexed, high-throughput DIA to map these changes across population scale cohorts, including protein PTMs and single-cell proteomes.
PSMtags - PTI - Parallel Squared Technology Institute
Parallel Squared Technology Institute is a non-profit research institute that’s scaling up proteomics to illuminate the link between protein patterns, functional interactions, and disease.
www.parallelsq.org
November 8, 2025 at 3:02 PM
We aim to enable this via plexDIA and new mass tags:
www.parallelsq.org/psmtags
They bring multiplexed, high-throughput DIA to map these changes across population scale cohorts, including protein PTMs and single-cell proteomes.
www.parallelsq.org/psmtags
They bring multiplexed, high-throughput DIA to map these changes across population scale cohorts, including protein PTMs and single-cell proteomes.
Reposted by Parallel Squared Technology Institute
Combining this time domain multiplexing with mass domain multiplexing (plexDIA), we demonstrated combinatorial scaling of throughput. You can read about it www.biorxiv.org/content/10.1... and hear Jason describe it at the Parallel Squared Technology Institute Research Fest: youtu.be/2rLBk4IaZpk?...
Increasing Mass spectrometry throughput using time encoded sample multiplexing | Jason Derks
YouTube video by Parallel Squared Technology Institute
youtu.be
November 1, 2025 at 4:59 PM
Combining this time domain multiplexing with mass domain multiplexing (plexDIA), we demonstrated combinatorial scaling of throughput. You can read about it www.biorxiv.org/content/10.1... and hear Jason describe it at the Parallel Squared Technology Institute Research Fest: youtu.be/2rLBk4IaZpk?...
Reposted by Parallel Squared Technology Institute
The counting statistics for single-cell MS support accurate estimates of protein abundance in single cells, which is essential for quantitative analysis.
Further, measuring and modeling protein degradation is key to biological interpretations.
pubs.acs.org/doi/10.1021/...
Further, measuring and modeling protein degradation is key to biological interpretations.
pubs.acs.org/doi/10.1021/...
Transformative Opportunities for Single-Cell Proteomics
Many pressing medical challenges, such as diagnosing disease, enhancing directed stem-cell differentiation, and classifying cancers, have long been hindered by limitations in our ability to quantify p...
pubs.acs.org
October 4, 2025 at 1:06 PM
The counting statistics for single-cell MS support accurate estimates of protein abundance in single cells, which is essential for quantitative analysis.
Further, measuring and modeling protein degradation is key to biological interpretations.
pubs.acs.org/doi/10.1021/...
Further, measuring and modeling protein degradation is key to biological interpretations.
pubs.acs.org/doi/10.1021/...
We developed approaches to increase the parallelization of proteomics in the mass and time domains and demonstrated 27x increased throughput.
They can scale further the throughput of the metabolic pulse proteomics demonstrated by @andrewleduc.bsky.social et al.
www.parallelsq.org/blog/proteom...
They can scale further the throughput of the metabolic pulse proteomics demonstrated by @andrewleduc.bsky.social et al.
www.parallelsq.org/blog/proteom...
Proteomics: Greater than the sum of its parts - PTI - Parallel Squared Technology Institute
Over the past 2 years, PTI synergized advances in computational sciences, chemistry, biology and mass spectrometry to develop the next generation of applications and methods in single cell proteomics.
www.parallelsq.org
September 21, 2025 at 1:38 PM
We developed approaches to increase the parallelization of proteomics in the mass and time domains and demonstrated 27x increased throughput.
They can scale further the throughput of the metabolic pulse proteomics demonstrated by @andrewleduc.bsky.social et al.
www.parallelsq.org/blog/proteom...
They can scale further the throughput of the metabolic pulse proteomics demonstrated by @andrewleduc.bsky.social et al.
www.parallelsq.org/blog/proteom...