Pagès lab
@pageslab.bsky.social
DNA damage and genome instability group Cancer Research Center of Marseille. #DNAdamage, #TranslesionSynthesis, #HomologousRecombination, in bacteria & yeast
open access version here: hal.science/hal-05250217
The RecBC complex protects single-stranded DNA gaps during lesion bypass
Following encounter with an unrepaired DNA lesion, replication is halted and can restart downstream of the lesion leading to the formation of a single-stranded DNA (ssDNA) gap. To complete replication...
hal.science
September 12, 2025 at 7:26 AM
open access version here: hal.science/hal-05250217
Our key findings:
-DNA polymerase η swiftly bypasses UV-induced lesions at the replication fork.
-Post-replicative gaps allow Translesion Synthesis (TLS) to compete with Damage Avoidance (DA), reducing mutagenicity.
-Gap extension by Exo1 nuclease favors DA and reduces TLS
-DNA polymerase η swiftly bypasses UV-induced lesions at the replication fork.
-Post-replicative gaps allow Translesion Synthesis (TLS) to compete with Damage Avoidance (DA), reducing mutagenicity.
-Gap extension by Exo1 nuclease favors DA and reduces TLS
March 24, 2025 at 10:42 AM
Our key findings:
-DNA polymerase η swiftly bypasses UV-induced lesions at the replication fork.
-Post-replicative gaps allow Translesion Synthesis (TLS) to compete with Damage Avoidance (DA), reducing mutagenicity.
-Gap extension by Exo1 nuclease favors DA and reduces TLS
-DNA polymerase η swiftly bypasses UV-induced lesions at the replication fork.
-Post-replicative gaps allow Translesion Synthesis (TLS) to compete with Damage Avoidance (DA), reducing mutagenicity.
-Gap extension by Exo1 nuclease favors DA and reduces TLS