phages (in white) being internalized by gut-lining cells, including enteroendocrine cells (in green). pink = nuclei of intestinal tissues.

virions closely associating with the intestinal mucosa and tissue...

The following videos reveals the aftermath of a phage outbreak: virions dispersed throughout the lumen...

We then brought Phollow into the gut of live zebrafish, taking advantage of their transparency and small size to visualize microbial communities across the entire intestine —capturing their dynamic interactions with the host in real time! pink = DNA, purple = actin, green = E. coli

One of my favorite experiments with Phollow are time lapses that allow us to illuminate the secret lives of phages. Here, we captured P2 temperate phages undergoing lytic replication in E. coli, leading to explosive host cell lysis and rapid virion dispersal into the environment.