This will enable a large-scale, systematic analysis of omics data that could transform prediction, diagnosis, and treatment of mental health conditions through new and personalised interventions

Find out more: www.ebi.ac.uk/about/news/a...

Co-led by Ellen McDonagh, our Translational Informatics Director, the Open Psychiatry Project has received a £2.3 million investment from the UKRI Medical Research Council and the National Institute for Health and Care Research.

Nearly one in seven people worldwide lives with a mental health condition, and current treatments are often ineffective.

Most psychiatric conditions have a strong genetic basis that we can study, but large-scale data analysis is needed to derive meaningful insights for patients.

USP18 is a negative regulator of interferon response, which suggests that the variant increases SLE risk by affecting USP18’s ability to limit the interferon response

Congratulations to the team on this work!

They found an interesting variant in the USP18 locus: a trans-eQTL that increases the expression of 50 interferon response genes. This variant also colocalises with a GWAS signal for systemic lupus erythematosus (SLE)

This release also features:

➡️ molQTL credible sets for targets
➡️ new options for the variant structural viewer
➡️ data updates from GWAS Catalog, Expression Atlas, gnomAD, DepMap, and Probes&Drugs

What do you think of this update?

@riyavsinha.bsky.social @jengreitz.bsky.social sky.social @anshulkundaje.bsky.social y.social have made the ENCODE-rE2G data available to browse through the E2G portal, a custom-built extension of the Platform 👇

We plan to further integrate their data 👀

e2g.stanford.edu

This new data can provide insights about the function of genetic variants by linking them to likely regulatory elements that affect the transcriptional activity of nearby genes, and is available to browse on our variant pages

This is fantastic — congratulations @gwascatalog.bsky.social!