Oliver O’Sullivan
@ollieosul.bsky.social
Assistant Professor, University of Nottingham | Rheumatology & Rehabilitation Medicine Doctor, British Army | NIHR Academic Clinical Lecturer | A/Editor, BMJ Military Health | Three rugrats, one dograt | Sports fan | Runner | He/him
Hi team, I’ve DM’d you!
August 14, 2025 at 7:38 AM
Hi team, I’ve DM’d you!
And although #Exercise has been shown to have great benefits for #OA, the evidence is solely lacking in the younger population, i.e. <45years old, and there is a heavy bias for older individuals!
bit.ly/45kkBa9
bit.ly/45kkBa9
August 5, 2025 at 3:52 PM
And although #Exercise has been shown to have great benefits for #OA, the evidence is solely lacking in the younger population, i.e. <45years old, and there is a heavy bias for older individuals!
bit.ly/45kkBa9
bit.ly/45kkBa9
And, there are experts around the world who can help such as OPTIKNEE & @oaactionalliance.bsky.social
- we can introduce high-quality consensus evidence into our population to prevent secondary #OA
bit.ly/3BGDzeY
- we can introduce high-quality consensus evidence into our population to prevent secondary #OA
bit.ly/3BGDzeY
August 5, 2025 at 3:52 PM
And, there are experts around the world who can help such as OPTIKNEE & @oaactionalliance.bsky.social
- we can introduce high-quality consensus evidence into our population to prevent secondary #OA
bit.ly/3BGDzeY
- we can introduce high-quality consensus evidence into our population to prevent secondary #OA
bit.ly/3BGDzeY
But what can we do about it??
The more we know about risk factors, the better we can target them.
The more individuals know about their condition, the better they can manage it.
There is a lot we can do.
bit.ly/3x4kEJ7
The more we know about risk factors, the better we can target them.
The more individuals know about their condition, the better they can manage it.
There is a lot we can do.
bit.ly/3x4kEJ7
August 5, 2025 at 3:52 PM
But what can we do about it??
The more we know about risk factors, the better we can target them.
The more individuals know about their condition, the better they can manage it.
There is a lot we can do.
bit.ly/3x4kEJ7
The more we know about risk factors, the better we can target them.
The more individuals know about their condition, the better they can manage it.
There is a lot we can do.
bit.ly/3x4kEJ7
We saw that this new technique and that some sub-maximal exercise influenced the concentrations of serum biomarkers - therefore, do we need to consider novel methods or 'exercise fasts' if we want to improve serum analysis?
bit.ly/4l1k15I
@f1000publishing.bsky.social
bit.ly/4l1k15I
@f1000publishing.bsky.social
August 5, 2025 at 3:52 PM
We saw that this new technique and that some sub-maximal exercise influenced the concentrations of serum biomarkers - therefore, do we need to consider novel methods or 'exercise fasts' if we want to improve serum analysis?
bit.ly/4l1k15I
@f1000publishing.bsky.social
bit.ly/4l1k15I
@f1000publishing.bsky.social
So, can we enhance this subtle signal? Perhaps a new technique might help, so we developed a novel sampling method closer to the joint in question, taking serum from local venous supply using ultrasound
bit.ly/459wJcY
@f1000publishing.bsky.social
bit.ly/459wJcY
@f1000publishing.bsky.social
August 5, 2025 at 3:52 PM
So, can we enhance this subtle signal? Perhaps a new technique might help, so we developed a novel sampling method closer to the joint in question, taking serum from local venous supply using ultrasound
bit.ly/459wJcY
@f1000publishing.bsky.social
bit.ly/459wJcY
@f1000publishing.bsky.social
Also, we saw different elements of the OARSI radiographic scale had slightly different molecular patterns, suggesting different pathophysiological processes underpinning these
bit.ly/4f7cG3g
bit.ly/4f7cG3g
August 5, 2025 at 3:52 PM
Also, we saw different elements of the OARSI radiographic scale had slightly different molecular patterns, suggesting different pathophysiological processes underpinning these
bit.ly/4f7cG3g
bit.ly/4f7cG3g
What about over time? Three years on in ADVANCE Study, #OA levels increase, but predictive ability was limited. However, we did see differences in trajectories, suggesting a heightened early risk and 'clinical window of maximal intervention'
bit.ly/4ood5CO
bit.ly/4ood5CO
August 5, 2025 at 3:52 PM
What about over time? Three years on in ADVANCE Study, #OA levels increase, but predictive ability was limited. However, we did see differences in trajectories, suggesting a heightened early risk and 'clinical window of maximal intervention'
bit.ly/4ood5CO
bit.ly/4ood5CO
So, what's new? In the ADVANCE Study (n=>1000,half injured ,half matched),COMP is up in in (fibrosis?!),down in knee-injury & amputees – cartilage health is vital for synthesis.Adipokines were a/w pain (phenotyping?!)& no diff between iOA and PTOA!
bit.ly/3CqQ4eG
@oacjournal.bsky.social
bit.ly/3CqQ4eG
@oacjournal.bsky.social
August 5, 2025 at 3:52 PM
So, what's new? In the ADVANCE Study (n=>1000,half injured ,half matched),COMP is up in in (fibrosis?!),down in knee-injury & amputees – cartilage health is vital for synthesis.Adipokines were a/w pain (phenotyping?!)& no diff between iOA and PTOA!
bit.ly/3CqQ4eG
@oacjournal.bsky.social
bit.ly/3CqQ4eG
@oacjournal.bsky.social
#MRI provides different data, w bone shape/position & cartilage morphology/composition giving some clues. Possibly in #PTOA, structural problems lead to compositional changes, vice versa in iOA. Heterogentity is an issue here too!
bit.ly/3GN8xoB
@oacjournal.bsky.social
bit.ly/3GN8xoB
@oacjournal.bsky.social
August 5, 2025 at 3:52 PM
#MRI provides different data, w bone shape/position & cartilage morphology/composition giving some clues. Possibly in #PTOA, structural problems lead to compositional changes, vice versa in iOA. Heterogentity is an issue here too!
bit.ly/3GN8xoB
@oacjournal.bsky.social
bit.ly/3GN8xoB
@oacjournal.bsky.social
From a molecular perspective, 51 serum and synovial fluid biomarkers have been examined, 11 of which had some associative value to #OA in the nearly 800 injured participants included in the review. Study heterogeneity is an issue!
bit.ly/473vcrf
@oacjournal.bsky.social
bit.ly/473vcrf
@oacjournal.bsky.social
August 5, 2025 at 3:52 PM
From a molecular perspective, 51 serum and synovial fluid biomarkers have been examined, 11 of which had some associative value to #OA in the nearly 800 injured participants included in the review. Study heterogeneity is an issue!
bit.ly/473vcrf
@oacjournal.bsky.social
bit.ly/473vcrf
@oacjournal.bsky.social
Prior to any new work starting, it was important to understand the existing literature, especially in the ‘chronic phase of PTOA’, a year or more from injury. Once all rehab pathways are complete and people have returned to play, what can we see?
August 5, 2025 at 3:52 PM
Prior to any new work starting, it was important to understand the existing literature, especially in the ‘chronic phase of PTOA’, a year or more from injury. Once all rehab pathways are complete and people have returned to play, what can we see?
In the British military, electronic health records under-report #OA, many factors inc EHR-limitations, diagnostic challenges and Service-related issues. We need to be mindful it occurs <45YO, especially in male, especially after injury!
bit.ly/3GZpa0o
bit.ly/3GZpa0o
August 5, 2025 at 3:52 PM
In the British military, electronic health records under-report #OA, many factors inc EHR-limitations, diagnostic challenges and Service-related issues. We need to be mindful it occurs <45YO, especially in male, especially after injury!
bit.ly/3GZpa0o
bit.ly/3GZpa0o
OA is complex, so I wanted provide a (simple) primer of what happens, why it happens and how we talk about it. It is important our termininology is specific to minimise generalisations. The more we know about risk factors, the better we can target them.
bit.ly/4m7NvAx
bit.ly/4m7NvAx
August 5, 2025 at 3:52 PM
OA is complex, so I wanted provide a (simple) primer of what happens, why it happens and how we talk about it. It is important our termininology is specific to minimise generalisations. The more we know about risk factors, the better we can target them.
bit.ly/4m7NvAx
bit.ly/4m7NvAx
Firstly, the population at risk and why #military individuals are at higher risk of #OA, especially #PTOA. We need to move from a management to prevention paradigm, and we need to improve identification tools such as biomarkers…
bit.ly/48HwZ4k
bit.ly/48HwZ4k
August 5, 2025 at 3:52 PM
Firstly, the population at risk and why #military individuals are at higher risk of #OA, especially #PTOA. We need to move from a management to prevention paradigm, and we need to improve identification tools such as biomarkers…
bit.ly/48HwZ4k
bit.ly/48HwZ4k
Thanks - I just missed this grad period cut-off, so will do it in Dec, but actually, by then I’ll be over the fatigue and be able to relish in the joy. Congrats right back at you, I hope it was a magical day!
July 22, 2025 at 6:37 PM
Thanks - I just missed this grad period cut-off, so will do it in Dec, but actually, by then I’ll be over the fatigue and be able to relish in the joy. Congrats right back at you, I hope it was a magical day!
For some serendipitous reasons, I seem to have combined recent PhD landmarks (viva, corrections resubmitted, PhD awarding) with major music concerts, so not much sleep (yet) but incredible throwback to my undergrad 20 years ago. It’s been ace!
July 22, 2025 at 6:36 PM
For some serendipitous reasons, I seem to have combined recent PhD landmarks (viva, corrections resubmitted, PhD awarding) with major music concerts, so not much sleep (yet) but incredible throwback to my undergrad 20 years ago. It’s been ace!
Thanks! I thought I would be looking for the dancing clowns firing bottles of champagne from confetti cannons by now… but all I want is a nap! Maybe I’ll go and find the clowns when I graduate…
July 21, 2025 at 6:18 PM
Thanks! I thought I would be looking for the dancing clowns firing bottles of champagne from confetti cannons by now… but all I want is a nap! Maybe I’ll go and find the clowns when I graduate…