Northwestern Basic Sciences
@nu-bsa.bsky.social
Making fundamental discoveries necessary to improve human health
https://www.feinberg.northwestern.edu/sites/bsa/index.html
https://www.feinberg.northwestern.edu/sites/bsa/index.html
Targeting neuronal signaling behind aberrant learning in the striatum may enhance first-line therapy for #Parkinsons and reduce therapy-related side effects, according to a Science Advances study led by D. James Surmeier, PhD.
Targeting Aberrant Learning May Improve Parkinson’s Treatment - News Center
Northwestern Medicine scientists have discovered that targeting neuronal signaling controlling aberrant learning in the striatum may improve the efficacy of a first-line therapy for Parkinson’s…
tinyurl.com
January 9, 2026 at 3:11 PM
Targeting neuronal signaling behind aberrant learning in the striatum may enhance first-line therapy for #Parkinsons and reduce therapy-related side effects, according to a Science Advances study led by D. James Surmeier, PhD.
Congratulations to Murali Prakriya, PhD, the Magerstadt Professor of Pharmacology, named a 2025 American Society for Pharmacology and Experimental Therapeutics Fellow — one of just 17 honorees recognized nationally for excellence in pharmacology, mentorship and service.
January 8, 2026 at 4:13 PM
Congratulations to Murali Prakriya, PhD, the Magerstadt Professor of Pharmacology, named a 2025 American Society for Pharmacology and Experimental Therapeutics Fellow — one of just 17 honorees recognized nationally for excellence in pharmacology, mentorship and service.
A new year means new discoveries! 🔬🎆 Join us this January for Basic Science seminars and events and let’s kick off 2026 with learning, collaboration, and curiosity.
Details🔗: tinyurl.com/9e34r7t6
Details🔗: tinyurl.com/9e34r7t6
January 7, 2026 at 2:38 PM
A new year means new discoveries! 🔬🎆 Join us this January for Basic Science seminars and events and let’s kick off 2026 with learning, collaboration, and curiosity.
Details🔗: tinyurl.com/9e34r7t6
Details🔗: tinyurl.com/9e34r7t6
Reposted by Northwestern Basic Sciences
If you missed the webinar held on December 2, 2025, you can watch the recording here: www.youtube.com/watch?v=LPlS...
Autism Across the Spectrum: From Understanding the Brain to Developing New Treatments 12.2.2025
YouTube video by Northwestern University Medical Alumni Association
www.youtube.com
January 6, 2026 at 3:59 PM
If you missed the webinar held on December 2, 2025, you can watch the recording here: www.youtube.com/watch?v=LPlS...
What happens when a cell’s internal scaffolding breaks down?
Vladimir Gelfand, PhD, explores how cytoskeletal disruptions could play a role in motor neuron diseases like #ALS on the latest episode of #BreakthroughsPodcast.
🔗 spr.ly/6017COtU3
Vladimir Gelfand, PhD, explores how cytoskeletal disruptions could play a role in motor neuron diseases like #ALS on the latest episode of #BreakthroughsPodcast.
🔗 spr.ly/6017COtU3
December 19, 2025 at 5:05 PM
What happens when a cell’s internal scaffolding breaks down?
Vladimir Gelfand, PhD, explores how cytoskeletal disruptions could play a role in motor neuron diseases like #ALS on the latest episode of #BreakthroughsPodcast.
🔗 spr.ly/6017COtU3
Vladimir Gelfand, PhD, explores how cytoskeletal disruptions could play a role in motor neuron diseases like #ALS on the latest episode of #BreakthroughsPodcast.
🔗 spr.ly/6017COtU3
Reposted by Northwestern Basic Sciences
🎙️Egon Ozer, MD, PhD, co-director of the Center for Pathogen Genomics and Microbial Evolution, discusses investigating global infectious disease threats in the new episode of #ExploreGlobalHealthPodcast.
Listen: www.globalhealth.northwestern.edu/events/podca...
Listen: www.globalhealth.northwestern.edu/events/podca...
December 10, 2025 at 4:02 PM
🎙️Egon Ozer, MD, PhD, co-director of the Center for Pathogen Genomics and Microbial Evolution, discusses investigating global infectious disease threats in the new episode of #ExploreGlobalHealthPodcast.
Listen: www.globalhealth.northwestern.edu/events/podca...
Listen: www.globalhealth.northwestern.edu/events/podca...
Reposted by Northwestern Basic Sciences
Iryna Boiko and Selma Mettane show that most gonococcal genomic sequences are from nonpiliated bacteria, even though clinical isolates are piliated.
Publicly Available Neisseria Gonorrhoeae Genomes Predominantly Represent In Vitro-Derived Nonpiliated Variants: academic.oup.com/jid/article/...
Publicly Available Neisseria Gonorrhoeae Genomes Predominantly Represent In Vitro-Derived Nonpiliated Variants: academic.oup.com/jid/article/...
Validate User
academic.oup.com
December 3, 2025 at 2:11 PM
Iryna Boiko and Selma Mettane show that most gonococcal genomic sequences are from nonpiliated bacteria, even though clinical isolates are piliated.
Publicly Available Neisseria Gonorrhoeae Genomes Predominantly Represent In Vitro-Derived Nonpiliated Variants: academic.oup.com/jid/article/...
Publicly Available Neisseria Gonorrhoeae Genomes Predominantly Represent In Vitro-Derived Nonpiliated Variants: academic.oup.com/jid/article/...
Reposted by Northwestern Basic Sciences
🚨The Yap Lab at Northwestern Univ is looking to fill 2 postdoc positions in 2026 to study aspects of Staphylococcus aureus antibiotic resistance and RNA synthesis-degradation. Please contact Frances Yap at [email protected] for details. sites.northwestern.edu/yaplab/. Pls repost #Microsky
Homepage | Yap Laboratory
sites.northwestern.edu
December 1, 2025 at 4:45 PM
🚨The Yap Lab at Northwestern Univ is looking to fill 2 postdoc positions in 2026 to study aspects of Staphylococcus aureus antibiotic resistance and RNA synthesis-degradation. Please contact Frances Yap at [email protected] for details. sites.northwestern.edu/yaplab/. Pls repost #Microsky
Reposted by Northwestern Basic Sciences
NEW PREPRINT led by stellar postdoc
@biophysben.bsky.social We turn diffusion models into inference machines. Score function→exact likelihoods, uncertainty estimate & interpretablity. Diffusion models generate. But classify? Untapped—until now @chanzuckerberg.bsky.social shorturl.at/s32uX
@biophysben.bsky.social We turn diffusion models into inference machines. Score function→exact likelihoods, uncertainty estimate & interpretablity. Diffusion models generate. But classify? Untapped—until now @chanzuckerberg.bsky.social shorturl.at/s32uX
December 2, 2025 at 6:03 PM
NEW PREPRINT led by stellar postdoc
@biophysben.bsky.social We turn diffusion models into inference machines. Score function→exact likelihoods, uncertainty estimate & interpretablity. Diffusion models generate. But classify? Untapped—until now @chanzuckerberg.bsky.social shorturl.at/s32uX
@biophysben.bsky.social We turn diffusion models into inference machines. Score function→exact likelihoods, uncertainty estimate & interpretablity. Diffusion models generate. But classify? Untapped—until now @chanzuckerberg.bsky.social shorturl.at/s32uX
This December, explore our basic science events and seminars featuring exciting research. Join us for opportunities to connect with colleagues across Feinberg.
Check out the event lineup here: tinyurl.com/dvyvrds4
Check out the event lineup here: tinyurl.com/dvyvrds4
December 1, 2025 at 2:25 PM
This December, explore our basic science events and seminars featuring exciting research. Join us for opportunities to connect with colleagues across Feinberg.
Check out the event lineup here: tinyurl.com/dvyvrds4
Check out the event lineup here: tinyurl.com/dvyvrds4
Reposted by Northwestern Basic Sciences
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 19, 2025 at 9:16 PM
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Reposted by Northwestern Basic Sciences
Join us this November for our virtual classes! Register here: galter.northwestern.edu/classes
November 5, 2025 at 1:52 PM
Join us this November for our virtual classes! Register here: galter.northwestern.edu/classes
Join us for basic science events and seminars in November.
🔗Explore upcoming talks, lectures and discussions: tinyurl.com/2tvstbce
🔗Explore upcoming talks, lectures and discussions: tinyurl.com/2tvstbce
October 31, 2025 at 2:11 PM
Join us for basic science events and seminars in November.
🔗Explore upcoming talks, lectures and discussions: tinyurl.com/2tvstbce
🔗Explore upcoming talks, lectures and discussions: tinyurl.com/2tvstbce
Reposted by Northwestern Basic Sciences
Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti...
!
!
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
www.sciencedirect.com
October 28, 2025 at 4:25 PM
Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti...
!
!
Reposted by Northwestern Basic Sciences
Online Now: Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle Online now:
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
Nengroo et al. show that succinate dehydrogenase (SDH) maintains purine synthesis. SDH inhibition elevates succinate, inducing SHMT2 succinylation that suppresses mitochondrial one-carbon flow and formate supply, thereby constraining purine assembly. Cancer cells compensate via purine salvage, and dual inhibition of SDH and salvage yields significant antiproliferative effects and suppresses tumor growth.
dlvr.it
October 28, 2025 at 7:15 PM
Online Now: Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle Online now:
Reposted by Northwestern Basic Sciences
DGP grad Sun Kim was first author of a recent study published in the Journal of Neuroscience! Read about the study: news.feinberg.northwestern.edu/2025/10/16/u...
Understanding Cellular Impacts of Neurodegeneration - News Center
A Northwestern Medicine study has revealed a key mechanism underlying the development of motor neuron diseases, offering new insights into potential treatment options, according to a study published i...
news.feinberg.northwestern.edu
October 22, 2025 at 7:03 PM
DGP grad Sun Kim was first author of a recent study published in the Journal of Neuroscience! Read about the study: news.feinberg.northwestern.edu/2025/10/16/u...
Reposted by Northwestern Basic Sciences
Congratulations to Dr. Yogesh Goyal on his appointment as a Mallinckrodt Foundation Grant Fellow!
Dr. Goyal is an active member of our CRS community, including serving as MS-RSM mentor and T32 faculty member.
news.feinberg.northwestern.edu/2025/10/13/g...
Dr. Goyal is an active member of our CRS community, including serving as MS-RSM mentor and T32 faculty member.
news.feinberg.northwestern.edu/2025/10/13/g...
Goyal Named Mallinckrodt Foundation Grant Fellow - News Center
Yogesh Goyal, PhD, assistant professor of Cell and Developmental Biology, has been named a 2025-2028 Edward Mallinckrodt, Jr. Foundation Grant Fellow, which recognizes early-stage biomedical investiga...
news.feinberg.northwestern.edu
October 23, 2025 at 2:28 PM
Congratulations to Dr. Yogesh Goyal on his appointment as a Mallinckrodt Foundation Grant Fellow!
Dr. Goyal is an active member of our CRS community, including serving as MS-RSM mentor and T32 faculty member.
news.feinberg.northwestern.edu/2025/10/13/g...
Dr. Goyal is an active member of our CRS community, including serving as MS-RSM mentor and T32 faculty member.
news.feinberg.northwestern.edu/2025/10/13/g...
Congratulations to Yogesh Goyal, PhD @goyallab.bsky.social, who was named a 2025–2028 Edward Mallinckrodt, Jr. Foundation Grant Fellow!
His work bridges engineering and biology to advance understanding of cellular plasticity and fate in development and disease. Learn more: tinyurl.com/2rumf48v
His work bridges engineering and biology to advance understanding of cellular plasticity and fate in development and disease. Learn more: tinyurl.com/2rumf48v
October 14, 2025 at 4:15 PM
Congratulations to Yogesh Goyal, PhD @goyallab.bsky.social, who was named a 2025–2028 Edward Mallinckrodt, Jr. Foundation Grant Fellow!
His work bridges engineering and biology to advance understanding of cellular plasticity and fate in development and disease. Learn more: tinyurl.com/2rumf48v
His work bridges engineering and biology to advance understanding of cellular plasticity and fate in development and disease. Learn more: tinyurl.com/2rumf48v
Reposted by Northwestern Basic Sciences
CAM Director Dina Arvanitis is currently in Banos, Ecuador, where she is co-organizer of the @biologists.bsky.social workshop Democratizing Microscopy in Latin America together with Mario Del Rosario, Fernanda Latorre, Helena De La Torre, Licyel Paulas, and Mariana De Niz. @nu-bsa.bsky.social
After 20 hours of travelling, some dinner with Constadina Arvanitis @camatnu.bsky.social, & a few hours of sleep, we'll be heading to Banos soon!
We were planning to share a picture of the view as we descended into Quito but unfortunately a thick layer of cloud had other ideas.
#BiologistsWorkshops
We were planning to share a picture of the view as we descended into Quito but unfortunately a thick layer of cloud had other ideas.
#BiologistsWorkshops
a blue sky with a lot of clouds moving in it
Alt: a blue sky with a lot of clouds moving in it
media.tenor.com
October 10, 2025 at 2:58 PM
CAM Director Dina Arvanitis is currently in Banos, Ecuador, where she is co-organizer of the @biologists.bsky.social workshop Democratizing Microscopy in Latin America together with Mario Del Rosario, Fernanda Latorre, Helena De La Torre, Licyel Paulas, and Mariana De Niz. @nu-bsa.bsky.social
Reposted by Northwestern Basic Sciences
Thanks for highlighting the work of Nikon Center Manager at CAM, Mariana De Niz. All the best at the Ecuador workshop!!! @nu-bsa.bsky.social @latambioimaging.bsky.social @bioimagingna.bsky.social
Sunrise over Spain, next stop Quito!
One of our Workshop organisers @marianadeniz.bsky.social was featured as one of our #100Biologists earlier this year. Mariana is the author of our Latin American Microscopists interview series.
#BiologistsWorkshops
focalplane.biologists.com/category/lat...
One of our Workshop organisers @marianadeniz.bsky.social was featured as one of our #100Biologists earlier this year. Mariana is the author of our Latin American Microscopists interview series.
#BiologistsWorkshops
focalplane.biologists.com/category/lat...
October 10, 2025 at 4:14 PM
Thanks for highlighting the work of Nikon Center Manager at CAM, Mariana De Niz. All the best at the Ecuador workshop!!! @nu-bsa.bsky.social @latambioimaging.bsky.social @bioimagingna.bsky.social
Congratulations to Richard Smith, PhD, on receiving the prestigious NIH Director’s New Innovator Award, recognizing early-career scientists leading high-risk, high-impact research in the biomedical, behavioral or social sciences.
Learn more about his work: tinyurl.com/yrhnk7bn
Learn more about his work: tinyurl.com/yrhnk7bn
October 10, 2025 at 2:11 PM
Congratulations to Richard Smith, PhD, on receiving the prestigious NIH Director’s New Innovator Award, recognizing early-career scientists leading high-risk, high-impact research in the biomedical, behavioral or social sciences.
Learn more about his work: tinyurl.com/yrhnk7bn
Learn more about his work: tinyurl.com/yrhnk7bn
Reposted by Northwestern Basic Sciences
Join us this October for our virtual classes! Register here: galter.northwestern.edu/classes
October 2, 2025 at 2:13 PM
Join us this October for our virtual classes! Register here: galter.northwestern.edu/classes
Reposted by Northwestern Basic Sciences
Postdoctoral Position (Please re-post)
A funded postdoctoral position, will open in 2026 to study aspects of Neisseria gonorrhoeae pathogenesis, antigenic variation, genetics, or physiology.
If interested in more information, please contact Hank Seifert
[email protected]
A funded postdoctoral position, will open in 2026 to study aspects of Neisseria gonorrhoeae pathogenesis, antigenic variation, genetics, or physiology.
If interested in more information, please contact Hank Seifert
[email protected]
September 5, 2025 at 2:13 PM
Postdoctoral Position (Please re-post)
A funded postdoctoral position, will open in 2026 to study aspects of Neisseria gonorrhoeae pathogenesis, antigenic variation, genetics, or physiology.
If interested in more information, please contact Hank Seifert
[email protected]
A funded postdoctoral position, will open in 2026 to study aspects of Neisseria gonorrhoeae pathogenesis, antigenic variation, genetics, or physiology.
If interested in more information, please contact Hank Seifert
[email protected]
🍂 This October, explore our basic science events and seminars showcasing exciting research and join us for opportunities to connect with colleagues across Feinberg.
Check out the full lineup here (link updated)👉 tinyurl.com/39z88nkp
Check out the full lineup here (link updated)👉 tinyurl.com/39z88nkp
October 2, 2025 at 4:01 PM
🍂 This October, explore our basic science events and seminars showcasing exciting research and join us for opportunities to connect with colleagues across Feinberg.
Check out the full lineup here (link updated)👉 tinyurl.com/39z88nkp
Check out the full lineup here (link updated)👉 tinyurl.com/39z88nkp
🎉 Congratulations to our recently promoted faculty in the Departments of Biochemistry and Molecular Genetics and of Pharmacology! We’re proud to celebrate their achievements in advancing science, education and discovery at Feinberg and beyond.
September 30, 2025 at 2:11 PM
🎉 Congratulations to our recently promoted faculty in the Departments of Biochemistry and Molecular Genetics and of Pharmacology! We’re proud to celebrate their achievements in advancing science, education and discovery at Feinberg and beyond.