Neuropsychopharmacology
@npp-journal.bsky.social
Neuropsychopharmacology (NPP) is an official peer-reviewed publication of the American College of Neuropsychopharmacology.
We report discoveries and promote training & outreach initiatives.
We report discoveries and promote training & outreach initiatives.
#ThisWeekInNPP
A single dose of psilocybin or a selective 5-HT2A agonist produces antidepressant-like effects in 🐀 lasting 3months; ephys showed functional plasticity in mPFC neurons, altered firing & excitability, without detectable structural or gene-expression changes
A single dose of psilocybin or a selective 5-HT2A agonist produces antidepressant-like effects in 🐀 lasting 3months; ephys showed functional plasticity in mPFC neurons, altered firing & excitability, without detectable structural or gene-expression changes
Psychedelics produce enduring behavioral effects and functional plasticity through mechanisms independent of structural plasticity - Neuropsychopharmacology
Neuropsychopharmacology - Psychedelics produce enduring behavioral effects and functional plasticity through mechanisms independent of structural plasticity
www.nature.com
November 26, 2025 at 1:24 AM
#ThisWeekInNPP
A single dose of psilocybin or a selective 5-HT2A agonist produces antidepressant-like effects in 🐀 lasting 3months; ephys showed functional plasticity in mPFC neurons, altered firing & excitability, without detectable structural or gene-expression changes
A single dose of psilocybin or a selective 5-HT2A agonist produces antidepressant-like effects in 🐀 lasting 3months; ephys showed functional plasticity in mPFC neurons, altered firing & excitability, without detectable structural or gene-expression changes
#ThisWeekInNPP
This longitudinal study found that ⬆️ adolescent cannabis use within individuals was linked to ⬇️cortical thickness, especially in ♂️ & in regions with⬆️ CB1 receptor expression
www.nature.com/articles/s41...
This longitudinal study found that ⬆️ adolescent cannabis use within individuals was linked to ⬇️cortical thickness, especially in ♂️ & in regions with⬆️ CB1 receptor expression
www.nature.com/articles/s41...
Independent brain cortical signatures of risk for adolescent cannabis use and consequences of such use are moderated by sex - Neuropsychopharmacology
Neuropsychopharmacology - Independent brain cortical signatures of risk for adolescent cannabis use and consequences of such use are moderated by sex
www.nature.com
November 26, 2025 at 1:24 AM
#ThisWeekInNPP
This longitudinal study found that ⬆️ adolescent cannabis use within individuals was linked to ⬇️cortical thickness, especially in ♂️ & in regions with⬆️ CB1 receptor expression
www.nature.com/articles/s41...
This longitudinal study found that ⬆️ adolescent cannabis use within individuals was linked to ⬇️cortical thickness, especially in ♂️ & in regions with⬆️ CB1 receptor expression
www.nature.com/articles/s41...
#ThisWeekInNPP
US data shows overdose deaths involving both synthetic opioids & stimulant rose from 2018 until 2023, then declined sharply in 2024, driven by ⬇️opioid-involved deaths. Despite recent declines, polydrug overdose mortality remains high
www.nature.com/articles/s41...
US data shows overdose deaths involving both synthetic opioids & stimulant rose from 2018 until 2023, then declined sharply in 2024, driven by ⬇️opioid-involved deaths. Despite recent declines, polydrug overdose mortality remains high
www.nature.com/articles/s41...
Polydrug overdose mortality caused by synthetic opioids and stimulants: current sex- and age-specific trajectories in United States national data for 2018–2024 - Neuropsychopharmacology
Neuropsychopharmacology - Polydrug overdose mortality caused by synthetic opioids and stimulants: current sex- and age-specific trajectories in United States national data for 2018–2024
www.nature.com
November 26, 2025 at 1:24 AM
#ThisWeekInNPP
US data shows overdose deaths involving both synthetic opioids & stimulant rose from 2018 until 2023, then declined sharply in 2024, driven by ⬇️opioid-involved deaths. Despite recent declines, polydrug overdose mortality remains high
www.nature.com/articles/s41...
US data shows overdose deaths involving both synthetic opioids & stimulant rose from 2018 until 2023, then declined sharply in 2024, driven by ⬇️opioid-involved deaths. Despite recent declines, polydrug overdose mortality remains high
www.nature.com/articles/s41...
#ThisWeekInNPP
In 🐀 model of cannabis vapor admin, ⬆️baseline corticosterone, ⬇️ morning anandamide, ⬇️set-shifting, ⬆️visual discrimination, &⬆️adolescent social grooming predicted ⬆️ responding for cannabis vapor / @ryanmcpickle.bsky.social
www.nature.com/articles/s41...
In 🐀 model of cannabis vapor admin, ⬆️baseline corticosterone, ⬇️ morning anandamide, ⬇️set-shifting, ⬆️visual discrimination, &⬆️adolescent social grooming predicted ⬆️ responding for cannabis vapor / @ryanmcpickle.bsky.social
www.nature.com/articles/s41...
Identifying behavioral and biological predictors of cannabis vapor self-administration in rats - Neuropsychopharmacology
Neuropsychopharmacology - Identifying behavioral and biological predictors of cannabis vapor self-administration in rats
www.nature.com
November 26, 2025 at 1:24 AM
#ThisWeekInNPP
In 🐀 model of cannabis vapor admin, ⬆️baseline corticosterone, ⬇️ morning anandamide, ⬇️set-shifting, ⬆️visual discrimination, &⬆️adolescent social grooming predicted ⬆️ responding for cannabis vapor / @ryanmcpickle.bsky.social
www.nature.com/articles/s41...
In 🐀 model of cannabis vapor admin, ⬆️baseline corticosterone, ⬇️ morning anandamide, ⬇️set-shifting, ⬆️visual discrimination, &⬆️adolescent social grooming predicted ⬆️ responding for cannabis vapor / @ryanmcpickle.bsky.social
www.nature.com/articles/s41...
#ThisWeekInNPP
Nolan R. Williams, M.D., Member of @acnporg.bsky.social passed away on October 8, 2025
Mark George & Harold Sackeim recount the impact of Dr. Nolan across the fields of neurostimulation, psychedelics, and more
www.nature.com/articles/s41...
Nolan R. Williams, M.D., Member of @acnporg.bsky.social passed away on October 8, 2025
Mark George & Harold Sackeim recount the impact of Dr. Nolan across the fields of neurostimulation, psychedelics, and more
www.nature.com/articles/s41...
IN MEMORIAM: Nolan R. Williams, MD - Neuropsychopharmacology
Neuropsychopharmacology - IN MEMORIAM: Nolan R. Williams, MD
www.nature.com
November 26, 2025 at 1:24 AM
#ThisWeekInNPP
Nolan R. Williams, M.D., Member of @acnporg.bsky.social passed away on October 8, 2025
Mark George & Harold Sackeim recount the impact of Dr. Nolan across the fields of neurostimulation, psychedelics, and more
www.nature.com/articles/s41...
Nolan R. Williams, M.D., Member of @acnporg.bsky.social passed away on October 8, 2025
Mark George & Harold Sackeim recount the impact of Dr. Nolan across the fields of neurostimulation, psychedelics, and more
www.nature.com/articles/s41...
#ThisWeekInNPP
How does the🧠signal unexpected reward timing? Is this perturbed in post-trauma psychopathology?
Fonzo & team find model-free & model-based fMRI evidence of abnormal amygdala & striatal signaling of temporal reward prediction errors
www.nature.com/articles/s41...
How does the🧠signal unexpected reward timing? Is this perturbed in post-trauma psychopathology?
Fonzo & team find model-free & model-based fMRI evidence of abnormal amygdala & striatal signaling of temporal reward prediction errors
www.nature.com/articles/s41...
Altered amygdala and striatal responsivity and prediction error encoding of temporal reward dynamics in post-trauma psychopathology - Neuropsychopharmacology
Neuropsychopharmacology - Altered amygdala and striatal responsivity and prediction error encoding of temporal reward dynamics in post-trauma psychopathology
www.nature.com
November 26, 2025 at 1:24 AM
#ThisWeekInNPP
How does the🧠signal unexpected reward timing? Is this perturbed in post-trauma psychopathology?
Fonzo & team find model-free & model-based fMRI evidence of abnormal amygdala & striatal signaling of temporal reward prediction errors
www.nature.com/articles/s41...
How does the🧠signal unexpected reward timing? Is this perturbed in post-trauma psychopathology?
Fonzo & team find model-free & model-based fMRI evidence of abnormal amygdala & striatal signaling of temporal reward prediction errors
www.nature.com/articles/s41...
#ThisWeekInNPP
This study identified an “opioid non-responder” phenotype in opioid-naive individuals using cumulative parenteral hydromorphone dosing: ~1/3 participants showed markedly ⬇️ subjective drug effects despite normal physiological responses
www.nature.com/articles/s41...
This study identified an “opioid non-responder” phenotype in opioid-naive individuals using cumulative parenteral hydromorphone dosing: ~1/3 participants showed markedly ⬇️ subjective drug effects despite normal physiological responses
www.nature.com/articles/s41...
Reliable variability in subjective responses to parenteral hydromorphone administration: empirical confirmation of an opioid non-responder phenotype - Neuropsychopharmacology
Neuropsychopharmacology - Reliable variability in subjective responses to parenteral hydromorphone administration: empirical confirmation of an opioid non-responder phenotype
www.nature.com
November 26, 2025 at 1:24 AM
#ThisWeekInNPP
This study identified an “opioid non-responder” phenotype in opioid-naive individuals using cumulative parenteral hydromorphone dosing: ~1/3 participants showed markedly ⬇️ subjective drug effects despite normal physiological responses
www.nature.com/articles/s41...
This study identified an “opioid non-responder” phenotype in opioid-naive individuals using cumulative parenteral hydromorphone dosing: ~1/3 participants showed markedly ⬇️ subjective drug effects despite normal physiological responses
www.nature.com/articles/s41...
November 26, 2025 at 1:24 AM
Dr. Anahita Bassir Nia focuses on translational research on the neurobiology of stress-related disorders and addiction, with a main focus on cannabinoids and psychedelics 🍄💊
November 24, 2025 at 6:41 PM
Dr. Anahita Bassir Nia focuses on translational research on the neurobiology of stress-related disorders and addiction, with a main focus on cannabinoids and psychedelics 🍄💊
Dr. Kolling uses biophysical, transcriptomic & molecular techniques to study how pathological tau rewires healthy neurons to a “diseased” state as it spreads #ACNP2026
He is a competitive powerlifter & coach 💪 & co-hosts the VA Vets First Podcast w/ Dr. Levi Sowers 🎙️/ @ljkolling.bsky.social
He is a competitive powerlifter & coach 💪 & co-hosts the VA Vets First Podcast w/ Dr. Levi Sowers 🎙️/ @ljkolling.bsky.social
November 24, 2025 at 6:41 PM
Dr. Kolling uses biophysical, transcriptomic & molecular techniques to study how pathological tau rewires healthy neurons to a “diseased” state as it spreads #ACNP2026
He is a competitive powerlifter & coach 💪 & co-hosts the VA Vets First Podcast w/ Dr. Levi Sowers 🎙️/ @ljkolling.bsky.social
He is a competitive powerlifter & coach 💪 & co-hosts the VA Vets First Podcast w/ Dr. Levi Sowers 🎙️/ @ljkolling.bsky.social
Dr. Karim Ibrahim explores brain biomarkers of emotion regulation in child psychiatric disorders using multimodal neuroimaging and connectomics; his work has identified dynamic connectivity markers linked to disruptive behavior in youth #ACNP2026
He is also a classical violinist 🎻
He is also a classical violinist 🎻
November 24, 2025 at 6:41 PM
Dr. Karim Ibrahim explores brain biomarkers of emotion regulation in child psychiatric disorders using multimodal neuroimaging and connectomics; his work has identified dynamic connectivity markers linked to disruptive behavior in youth #ACNP2026
He is also a classical violinist 🎻
He is also a classical violinist 🎻
Dr. Nicole Short is an Assistant Professor of Psychology at the University of Nevada, Las Vegas and a licensed clinical psychologist #ACNP2026
Her research focuses on the etiology, prevention, & treatment of co-occurring posttraumatic stress disorder & cannabis use disorder
Her research focuses on the etiology, prevention, & treatment of co-occurring posttraumatic stress disorder & cannabis use disorder
November 24, 2025 at 6:41 PM
Dr. Nicole Short is an Assistant Professor of Psychology at the University of Nevada, Las Vegas and a licensed clinical psychologist #ACNP2026
Her research focuses on the etiology, prevention, & treatment of co-occurring posttraumatic stress disorder & cannabis use disorder
Her research focuses on the etiology, prevention, & treatment of co-occurring posttraumatic stress disorder & cannabis use disorder
Dr. Clancy examines how sensory systems in trauma-exposed people give rise to intrusive trauma memories & how portable neurotherapeutics can fix this #ACNP2026
Outside the lab, he helps develop & implement psychosocial support programs for refugees in Lebanon, Syria, & Palestine
Outside the lab, he helps develop & implement psychosocial support programs for refugees in Lebanon, Syria, & Palestine
November 24, 2025 at 6:41 PM
Dr. Clancy examines how sensory systems in trauma-exposed people give rise to intrusive trauma memories & how portable neurotherapeutics can fix this #ACNP2026
Outside the lab, he helps develop & implement psychosocial support programs for refugees in Lebanon, Syria, & Palestine
Outside the lab, he helps develop & implement psychosocial support programs for refugees in Lebanon, Syria, & Palestine
Dr. Doss is interested in effects of psychoactive drugs on memory, especially the impact of psychedelics on human episodic memory #ACNP2026
He likes aggressive skating (rollerblading w/ tricks, grinds etc) & a concussion while blading led to his interest in memory research / @manojdoss.bsky.social
He likes aggressive skating (rollerblading w/ tricks, grinds etc) & a concussion while blading led to his interest in memory research / @manojdoss.bsky.social
November 24, 2025 at 6:41 PM
Dr. Doss is interested in effects of psychoactive drugs on memory, especially the impact of psychedelics on human episodic memory #ACNP2026
He likes aggressive skating (rollerblading w/ tricks, grinds etc) & a concussion while blading led to his interest in memory research / @manojdoss.bsky.social
He likes aggressive skating (rollerblading w/ tricks, grinds etc) & a concussion while blading led to his interest in memory research / @manojdoss.bsky.social
We're excited to showcase another group of the stellar
@acnporg.bsky.social Travel Awardees who will be joining us for #ACNP2026 🤩
See below for more about them, their research, and other fun facts 👇
@acnporg.bsky.social Travel Awardees who will be joining us for #ACNP2026 🤩
See below for more about them, their research, and other fun facts 👇
November 24, 2025 at 6:41 PM
We're excited to showcase another group of the stellar
@acnporg.bsky.social Travel Awardees who will be joining us for #ACNP2026 🤩
See below for more about them, their research, and other fun facts 👇
@acnporg.bsky.social Travel Awardees who will be joining us for #ACNP2026 🤩
See below for more about them, their research, and other fun facts 👇