NOTCH UK - The National Oncology Trainee Collaborative for Healt
@notchonctrainees.bsky.social
The National Oncology Trainee Collaborative for Healthcare Research - a UK-wide trainee-led collaborative aiming to increase participation in cancer research and support resident doctors in gaining oncology research experience.
Conclusions:
🔵Acceptably low primary emergence rates
🔵Lower toxicity with INO radiotherapy
🔵No OS difference vs MUC
🔵INO may be a feasible alternative in modern practice
www.redjournal.org/article/S036...
🔵Acceptably low primary emergence rates
🔵Lower toxicity with INO radiotherapy
🔵No OS difference vs MUC
🔵INO may be a feasible alternative in modern practice
www.redjournal.org/article/S036...
Involved neck only versus mucosal radiotherapy for head and neck squamous cell cancer of unknown primary (HNSCCUP): a national retrospective multicentre cohort study
Introduction: Target volumes for irradiation remain ill-defined for head and neck
squamous cell cancer of unknown primary (HNSCCUP). The aim of this study was to compare
two commonly used radiotherapy...
www.redjournal.org
November 29, 2025 at 1:53 PM
Conclusions:
🔵Acceptably low primary emergence rates
🔵Lower toxicity with INO radiotherapy
🔵No OS difference vs MUC
🔵INO may be a feasible alternative in modern practice
www.redjournal.org/article/S036...
🔵Acceptably low primary emergence rates
🔵Lower toxicity with INO radiotherapy
🔵No OS difference vs MUC
🔵INO may be a feasible alternative in modern practice
www.redjournal.org/article/S036...
Survival Data (see paper for full data, and sub-group analysis)
5-yr OS was similar between INO and MUC RT groups, 82% and 80%.
Death from other causes (not HNSCUP) was higher in MUC RT cohort (p=0.003).
Primary site emergence was rare, occurring in only 3/195 patients (1.5%)
5-yr OS was similar between INO and MUC RT groups, 82% and 80%.
Death from other causes (not HNSCUP) was higher in MUC RT cohort (p=0.003).
Primary site emergence was rare, occurring in only 3/195 patients (1.5%)
November 29, 2025 at 1:53 PM
Survival Data (see paper for full data, and sub-group analysis)
5-yr OS was similar between INO and MUC RT groups, 82% and 80%.
Death from other causes (not HNSCUP) was higher in MUC RT cohort (p=0.003).
Primary site emergence was rare, occurring in only 3/195 patients (1.5%)
5-yr OS was similar between INO and MUC RT groups, 82% and 80%.
Death from other causes (not HNSCUP) was higher in MUC RT cohort (p=0.003).
Primary site emergence was rare, occurring in only 3/195 patients (1.5%)
Treatment and toxicity:
🔵RT dose/fractionation differed notably, with MUC receiving higher-dose schedules.
🔵Acute feeding-tube use was higher in MUC (33% vs 11%, p<0.001).
🔵NTCP for grade ≥2 xerostomia at 6 months was significantly higher in MUC group
🔵RT dose/fractionation differed notably, with MUC receiving higher-dose schedules.
🔵Acute feeding-tube use was higher in MUC (33% vs 11%, p<0.001).
🔵NTCP for grade ≥2 xerostomia at 6 months was significantly higher in MUC group
November 29, 2025 at 1:53 PM
Treatment and toxicity:
🔵RT dose/fractionation differed notably, with MUC receiving higher-dose schedules.
🔵Acute feeding-tube use was higher in MUC (33% vs 11%, p<0.001).
🔵NTCP for grade ≥2 xerostomia at 6 months was significantly higher in MUC group
🔵RT dose/fractionation differed notably, with MUC receiving higher-dose schedules.
🔵Acute feeding-tube use was higher in MUC (33% vs 11%, p<0.001).
🔵NTCP for grade ≥2 xerostomia at 6 months was significantly higher in MUC group
Study Design:
Retrospective observational multi-centre study
18 UK cancer centres
Outcomes of interest: OS, emergence of primary site, disease relapse/recurrence, toxicity, and enteral feeding rates.
Retrospective observational multi-centre study
18 UK cancer centres
Outcomes of interest: OS, emergence of primary site, disease relapse/recurrence, toxicity, and enteral feeding rates.
November 29, 2025 at 1:53 PM
Study Design:
Retrospective observational multi-centre study
18 UK cancer centres
Outcomes of interest: OS, emergence of primary site, disease relapse/recurrence, toxicity, and enteral feeding rates.
Retrospective observational multi-centre study
18 UK cancer centres
Outcomes of interest: OS, emergence of primary site, disease relapse/recurrence, toxicity, and enteral feeding rates.
Study Aims:
🔵The aim of the study was to directly compare involved neck only (INO) RT versus bilateral neck and/or mucosal irradiation in patients with unilateral HNSCCUP.
🔵The aim of the study was to directly compare involved neck only (INO) RT versus bilateral neck and/or mucosal irradiation in patients with unilateral HNSCCUP.
November 29, 2025 at 1:53 PM
Study Aims:
🔵The aim of the study was to directly compare involved neck only (INO) RT versus bilateral neck and/or mucosal irradiation in patients with unilateral HNSCCUP.
🔵The aim of the study was to directly compare involved neck only (INO) RT versus bilateral neck and/or mucosal irradiation in patients with unilateral HNSCCUP.
Background:
🔵Management of HNSCCUP remains controversial, particularly regarding the optimal RT strategy, as traditional approaches have favoured comprehensive irradiation of bilateral neck and mucosal sites to minimize the risk of missing an occult primary.
🔵Management of HNSCCUP remains controversial, particularly regarding the optimal RT strategy, as traditional approaches have favoured comprehensive irradiation of bilateral neck and mucosal sites to minimize the risk of missing an occult primary.
November 29, 2025 at 1:53 PM
Background:
🔵Management of HNSCCUP remains controversial, particularly regarding the optimal RT strategy, as traditional approaches have favoured comprehensive irradiation of bilateral neck and mucosal sites to minimize the risk of missing an occult primary.
🔵Management of HNSCCUP remains controversial, particularly regarding the optimal RT strategy, as traditional approaches have favoured comprehensive irradiation of bilateral neck and mucosal sites to minimize the risk of missing an occult primary.
Abstract submission link: shorturl.at/zmz4X
Eventbrite registration: shorturl.at/cyYvK
More information: www.cruk.cam.ac.uk/seminars/cam...
Eventbrite registration: shorturl.at/cyYvK
More information: www.cruk.cam.ac.uk/seminars/cam...
Cambridge Head and Neck Cancer Symposium, 25th Sep 2025 - Cancer Research UK Cambridge Institute
Cambridge Head and Neck Cancer Symposium, 25th Sep 2025 Register now for CamHNC2025. This regional event is suitable for PhD students, postdocs, junior group leaders, clinicians of all grades, nurses,...
www.cruk.cam.ac.uk
August 13, 2025 at 1:06 PM
Abstract submission link: shorturl.at/zmz4X
Eventbrite registration: shorturl.at/cyYvK
More information: www.cruk.cam.ac.uk/seminars/cam...
Eventbrite registration: shorturl.at/cyYvK
More information: www.cruk.cam.ac.uk/seminars/cam...
Link to register: events.teams.microsoft.com/event/e09e43...
Microsoft Virtual Events Powered by Teams
Microsoft Virtual Events Powered by Teams
events.teams.microsoft.com
June 29, 2025 at 5:58 PM
Link to register: events.teams.microsoft.com/event/e09e43...