Whaaaaaat??? I may have to join you in screaming.... I already had to submit again after an (unfair IMO) admin withdrawal from a June submission... We cannot go on like this.

Very pretty but is it a time-lapse or single time point going through the z-stack?

Ahhh, the late 90's were the best! 😊

One thing to realize is that it's a patchwork of phenotypes, some cells with normal apical surface and some enlarged. We think many cells can succeed at abscission without Cep55, but the rate of failure increases. If p53 deleted, mistakes can add up over multiple cell cycles....

Ooh, great questions! We haven't seen extra folds or noticeable ventricle shape changes. Tension could change but we don't have a good way to measure that. It does not appear that cells are extruded.

Thanks Pleasantine! 😀 In a previous paper, we showed that preventing apoptosis in Cep55 ko via p53 dKO only partly rescued brain size and thickness, made other neurogenesis phenotypes worse. www.jneurosci.org/content/41/1... ...Relevant figure here: www.jneurosci.org/content/jneu...

Thank you so much!