I think it's fair to say that we don't know whether this is indeed feasible, and adds value (by preventing trials that would have failed anyway). Time will tell.

In my opinion, this makes perfect sense and can potentially avoid a lot of failed trials. But I don't think digital twins can ever replace clinical trials. In-silico trials should sit before clinical trials on the translational pathway.

The concept of Digital Twins is now being explored in healthcare technologies engineering, in particular whether they can have a role in the translational pathway for new technologies. The idea is that we test the design of a new in vivo medical device before it is actually built.

Hi @janekohara.bsky.social, belated reply to this post. Digital twins are an established methodology in engineering (e.g. aviation), used to evaluate and stress-test new designs in a virtal environment before they are manufactured and tested in the real world.