Steffen Flindt Nielsen
@nicenielsen.bsky.social
Man what a time to be practicing! So many ecxiting trials… my money is on Piesces! That trial totally blind sided me
November 26, 2025 at 4:24 PM
Man what a time to be practicing! So many ecxiting trials… my money is on Piesces! That trial totally blind sided me
Good analysis, as always, though I’m not sure the administration’s aims are noble or admirable. they are cynical. This is not a proposal for peace but for surrender.
November 21, 2025 at 6:25 PM
Good analysis, as always, though I’m not sure the administration’s aims are noble or admirable. they are cynical. This is not a proposal for peace but for surrender.
Copenhagen is different, politically, from the rest of Denmark though. The prime minister has been a social democrat since 2019 and there is broad political and voter consensus on a strict immigration policy for more than a decade + far right parties are mostly marginalised here
November 18, 2025 at 4:47 PM
Copenhagen is different, politically, from the rest of Denmark though. The prime minister has been a social democrat since 2019 and there is broad political and voter consensus on a strict immigration policy for more than a decade + far right parties are mostly marginalised here
Copenhagen is different, politically, from the rest of Denmark though. The prime minister has been a social democrat since 2019 and there is broad political and voter consensus on a strict immigration policy for more than a decade + far right parties are mostly marginalised here
November 18, 2025 at 4:45 PM
Copenhagen is different, politically, from the rest of Denmark though. The prime minister has been a social democrat since 2019 and there is broad political and voter consensus on a strict immigration policy for more than a decade + far right parties are mostly marginalised here
But really, should we give fish oil to dialysis patients? - THAT’S the key question
November 13, 2025 at 12:59 PM
But really, should we give fish oil to dialysis patients? - THAT’S the key question
yeah I don’t think we really disagree on this topic, though it seems we would disagree on larger policy points
November 13, 2025 at 12:52 PM
yeah I don’t think we really disagree on this topic, though it seems we would disagree on larger policy points
It would be better to find societal solutions to societal problems, sure. But as a practicing clinician this issue is a non-starter. We have to help patients within the existing framework. And Ozempic is great at that
November 13, 2025 at 11:57 AM
It would be better to find societal solutions to societal problems, sure. But as a practicing clinician this issue is a non-starter. We have to help patients within the existing framework. And Ozempic is great at that
😂 this thread has come a long way
November 13, 2025 at 8:36 AM
😂 this thread has come a long way
Nice comment. Thanks
November 13, 2025 at 8:22 AM
Nice comment. Thanks
Congratulation, Kevan, on the study. A really impressive acomplishment.
November 10, 2025 at 3:35 PM
Congratulation, Kevan, on the study. A really impressive acomplishment.
BMI requirements vary quite a bit between centers Denmark is generally pretty strict - we usually require BMI < 30 at my center.
November 9, 2025 at 1:18 PM
BMI requirements vary quite a bit between centers Denmark is generally pretty strict - we usually require BMI < 30 at my center.
Reposted by Steffen Flindt Nielsen
I think everyone is rightly sceptical if the large effect size, but given the high risk CVD risk and low cost/risk with fish oil, I feel it is too reactionary to just say “we need more trials”. We always need more trials, but they’re not likely to be forthcoming any time soon.
#NephSky
#NephSky
November 9, 2025 at 12:00 PM
I think everyone is rightly sceptical if the large effect size, but given the high risk CVD risk and low cost/risk with fish oil, I feel it is too reactionary to just say “we need more trials”. We always need more trials, but they’re not likely to be forthcoming any time soon.
#NephSky
#NephSky
Yeah if the ever come at all
November 9, 2025 at 12:13 PM
Yeah if the ever come at all
I suppose we would hypothesize cardiovascular protection with fish oil… but those HR’s are really something. and the separation is within the first 6 months. I’m certainly also sceptical, but I still feel like we should start perscribing.
November 9, 2025 at 12:11 PM
I suppose we would hypothesize cardiovascular protection with fish oil… but those HR’s are really something. and the separation is within the first 6 months. I’m certainly also sceptical, but I still feel like we should start perscribing.
Yeah, my thoughts ecxactly
November 9, 2025 at 11:36 AM
Yeah, my thoughts ecxactly
… and the trial: www.nejm.org/doi/full/10....
Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis | NEJM
Cardiovascular disease is the leading cause of death in patients receiving hemodialysis,
yet effective preventive therapies remain limited. Supplementation with n−3 polyunsaturated
fatty acids, esp...
www.nejm.org
November 9, 2025 at 11:27 AM
… and the trial: www.nejm.org/doi/full/10....
I just think that a trial with a composite outcome would give us much better information and would not be unreasonable to demand from a big company like Bayer..
November 6, 2025 at 9:12 PM
I just think that a trial with a composite outcome would give us much better information and would not be unreasonable to demand from a big company like Bayer..
Agreed. though I will admit it is a bit of a luxury problem. One possible solution, if it‘s not everything for everybody, could be to individualize based on disease fenotype: www.nature.com/articles/s41....
Combination therapy for kidney disease in people with diabetes mellitus - Nature Reviews Nephrology
Several new drug classes have been demonstrated to improve kidney outcomes in people with diabetes mellitus. Here, the authors examine the evidence for the efficacy and safety of combination treatment...
www.nature.com
November 6, 2025 at 8:27 PM
Agreed. though I will admit it is a bit of a luxury problem. One possible solution, if it‘s not everything for everybody, could be to individualize based on disease fenotype: www.nature.com/articles/s41....
Fair point! It’s just that when they need 33000 patients to power a trial for hard outcomes, as it was for CONFIDENCE, I get a little worried whether there is an relevant benefit
November 6, 2025 at 8:04 PM
Fair point! It’s just that when they need 33000 patients to power a trial for hard outcomes, as it was for CONFIDENCE, I get a little worried whether there is an relevant benefit
Strange that SBP did not differ from placebo treatment 🤔
November 6, 2025 at 7:58 PM
Strange that SBP did not differ from placebo treatment 🤔
I am willing to accept surrogate outcomes for rare diseases, but for things like DKD there is really no good reason to not demand hard clinical outcomes IMO
November 6, 2025 at 7:47 PM
I am willing to accept surrogate outcomes for rare diseases, but for things like DKD there is really no good reason to not demand hard clinical outcomes IMO
There is an ongoing danish study called APPLE TREE randomizing patients who are being perscribed SGLT2i to either empa, dapa or cana. Maybe we’ll ger the answer here: lundbeckfonden.com/en/the-apple...
The APPLE TREE study
Daniel Christensen, Department of Cardiology, Herlev and Gentofte Hospital, has been awarded an Early-career clinician scientist research grant worth DKK 916.199.
lundbeckfonden.com
October 21, 2025 at 6:34 PM
There is an ongoing danish study called APPLE TREE randomizing patients who are being perscribed SGLT2i to either empa, dapa or cana. Maybe we’ll ger the answer here: lundbeckfonden.com/en/the-apple...