Ying Cao
@neuralgrndstate.bsky.social
Cancer is a systemic disease. Understanding a systemic disease needs systemic rules: Tumorigenesis is a process of progressive loss of original cell identity and gain of neural stemness, the general stemness that determines tumorigenicity and pluripotency.
As generalized before, most cancer promoting (incl. therapy resistance) genes are embryonic neural/neural stemness genes, incl. zbtb16.
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
www.preprints.org
November 17, 2025 at 12:22 PM
As generalized before, most cancer promoting (incl. therapy resistance) genes are embryonic neural/neural stemness genes, incl. zbtb16.
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell'
www.preprints.org/manuscript/2...
The symbol ZBTB16 identifies a 'new type' of cancer cell.
But according to embryonic neural expression of ZBTB16, it does not.
Because cancer cell shares regulatory network with embryonic neural cells, &neural stemness unifies phenotypic traits of cancer cell incl. resistance.
But according to embryonic neural expression of ZBTB16, it does not.
Because cancer cell shares regulatory network with embryonic neural cells, &neural stemness unifies phenotypic traits of cancer cell incl. resistance.
November 17, 2025 at 12:20 PM
The symbol ZBTB16 identifies a 'new type' of cancer cell.
But according to embryonic neural expression of ZBTB16, it does not.
Because cancer cell shares regulatory network with embryonic neural cells, &neural stemness unifies phenotypic traits of cancer cell incl. resistance.
But according to embryonic neural expression of ZBTB16, it does not.
Because cancer cell shares regulatory network with embryonic neural cells, &neural stemness unifies phenotypic traits of cancer cell incl. resistance.
‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’
preprints.org/manuscript/2...
preprints.org/manuscript/2...
November 7, 2025 at 7:24 AM
‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’
preprints.org/manuscript/2...
preprints.org/manuscript/2...
For knowing what is embryonic (neural) induction, refer to the experiment done by Spemann and Mangold in 1924 and subsequent studies.
October 29, 2025 at 6:06 AM
For knowing what is embryonic (neural) induction, refer to the experiment done by Spemann and Mangold in 1924 and subsequent studies.