Nature Methods
@natmethods.nature.com
A scientific journal publishing cutting-edge methods, tools, analyses, resources, reviews, news and commentary, supporting life sciences research. Posts by the editors.
Our November issue is now live! 🎉
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On the cover, cell tracking in a developing zebrafish embryo visualized using Ultrack. Cover by Alexandre Dizieux, Jordão Bragantini, Loic Royer, Merlin Lange, CZ Biohub. Paper here: www.nature.com/articles/s41...
www.nature.com/nmeth/volume...
On the cover, cell tracking in a developing zebrafish embryo visualized using Ultrack. Cover by Alexandre Dizieux, Jordão Bragantini, Loic Royer, Merlin Lange, CZ Biohub. Paper here: www.nature.com/articles/s41...
November 13, 2025 at 8:38 PM
Our November issue is now live! 🎉
www.nature.com/nmeth/volume...
On the cover, cell tracking in a developing zebrafish embryo visualized using Ultrack. Cover by Alexandre Dizieux, Jordão Bragantini, Loic Royer, Merlin Lange, CZ Biohub. Paper here: www.nature.com/articles/s41...
www.nature.com/nmeth/volume...
On the cover, cell tracking in a developing zebrafish embryo visualized using Ultrack. Cover by Alexandre Dizieux, Jordão Bragantini, Loic Royer, Merlin Lange, CZ Biohub. Paper here: www.nature.com/articles/s41...
High-resolution imaging mass cytometry enables highly multiplexed imaging of nuclear foci and mitochondrial networks.
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October 30, 2025 at 3:41 PM
High-resolution imaging mass cytometry enables highly multiplexed imaging of nuclear foci and mitochondrial networks.
www.nature.com/articles/s41...
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Our latest Creature Column features the gray mouse lemur, a model for primate brain evolution, cognition, aging and neurodegenerative diseases.
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October 14, 2025 at 5:49 PM
Our latest Creature Column features the gray mouse lemur, a model for primate brain evolution, cognition, aging and neurodegenerative diseases.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our October issue is live! 🥳
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On the cover, single-cell DNA-RNA sequencing (SDR-seq) links genetic variants to gene expression. Artwork by Tobias Wuestefeld. Paper here: www.nature.com/articles/s41...
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On the cover, single-cell DNA-RNA sequencing (SDR-seq) links genetic variants to gene expression. Artwork by Tobias Wuestefeld. Paper here: www.nature.com/articles/s41...
October 10, 2025 at 2:07 PM
Our October issue is live! 🥳
www.nature.com/nmeth/volume...
On the cover, single-cell DNA-RNA sequencing (SDR-seq) links genetic variants to gene expression. Artwork by Tobias Wuestefeld. Paper here: www.nature.com/articles/s41...
www.nature.com/nmeth/volume...
On the cover, single-cell DNA-RNA sequencing (SDR-seq) links genetic variants to gene expression. Artwork by Tobias Wuestefeld. Paper here: www.nature.com/articles/s41...
Laser ablation of imaged surface layers under adaptive control enables volumetric imaging of heterogeneous tissue like skull and brain.
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October 3, 2025 at 1:31 PM
Laser ablation of imaged surface layers under adaptive control enables volumetric imaging of heterogeneous tissue like skull and brain.
www.nature.com/articles/s41...
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We are thrilled to present a special September issue highlighting recent methods in the field of cancer biology.
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September 19, 2025 at 2:54 PM
We are thrilled to present a special September issue highlighting recent methods in the field of cancer biology.
www.nature.com/articles/s41...
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A new Perspective discusses the challenges of sharing annotated image datasets and offers advice for improving bioimage annotation and reuse, particularly for AI applications.
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September 17, 2025 at 2:56 PM
A new Perspective discusses the challenges of sharing annotated image datasets and offers advice for improving bioimage annotation and reuse, particularly for AI applications.
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CLEM-Reg automates the 3D alignment of volume correlative light and electron microscopy data.
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September 11, 2025 at 2:25 PM
CLEM-Reg automates the 3D alignment of volume correlative light and electron microscopy data.
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Scvi-hub is a versatile and efficient platform for model-based analysis of single-cell sequencing studies with access to a diverse array of datasets and downstream analysis. @canergen.bsky.social
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September 9, 2025 at 1:25 PM
Scvi-hub is a versatile and efficient platform for model-based analysis of single-cell sequencing studies with access to a diverse array of datasets and downstream analysis. @canergen.bsky.social
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Introducing TCAT, a pipeline to simultaneously capture gene expression programs related to T cell subsets and activation states.
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September 3, 2025 at 4:49 PM
Introducing TCAT, a pipeline to simultaneously capture gene expression programs related to T cell subsets and activation states.
www.nature.com/articles/s41...
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SDR-seq is a droplet-based single-cell DNA-RNA sequencing platform for studying gene expression profiles linked to both noncoding and coding variants.
www.nature.com/articles/s41...
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September 3, 2025 at 4:41 PM
SDR-seq is a droplet-based single-cell DNA-RNA sequencing platform for studying gene expression profiles linked to both noncoding and coding variants.
www.nature.com/articles/s41...
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This month's Creature Column features the tubeworm Hydroides elegans - much maligned as a shipyard biofouling pest, but also a useful model organism for studying development, biomineralization and marine microbiology.
www.nature.com/articles/s41...
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August 13, 2025 at 5:42 PM
This month's Creature Column features the tubeworm Hydroides elegans - much maligned as a shipyard biofouling pest, but also a useful model organism for studying development, biomineralization and marine microbiology.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
MAPIT-seq is an antibody-guided RNA editing method for co-profiling RBP-RNA interactions and gene expression in single cells and tissue.
www.nature.com/articles/s41...
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August 11, 2025 at 2:56 PM
MAPIT-seq is an antibody-guided RNA editing method for co-profiling RBP-RNA interactions and gene expression in single cells and tissue.
www.nature.com/articles/s41...
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A paper from the JUMP Cell Painting Consortium presents image-based phenotypic profiles for 75% of the protein coding genome of human U-2 OS cells, offering a valuable resource for exploring gene relationships. @shantanu-singh.cc @drannecarpenter.bsky.social
www.nature.com/articles/s41...
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August 7, 2025 at 8:01 PM
A paper from the JUMP Cell Painting Consortium presents image-based phenotypic profiles for 75% of the protein coding genome of human U-2 OS cells, offering a valuable resource for exploring gene relationships. @shantanu-singh.cc @drannecarpenter.bsky.social
www.nature.com/articles/s41...
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Interact-omics is a high-throughput cytometry-based framework for cellular interaction mapping. @simonhaas.bsky.social
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August 7, 2025 at 7:53 PM
Interact-omics is a high-throughput cytometry-based framework for cellular interaction mapping. @simonhaas.bsky.social
www.nature.com/articles/s41...
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Our August issue is live! 🎉
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On the cover, a cost-effective and scalable DNA sequencing approach by roll-to-roll fluidics.
Paper: www.nature.com/articles/s41...
nature.com/nmeth/volume...
On the cover, a cost-effective and scalable DNA sequencing approach by roll-to-roll fluidics.
Paper: www.nature.com/articles/s41...
August 7, 2025 at 5:57 PM
Our August issue is live! 🎉
nature.com/nmeth/volume...
On the cover, a cost-effective and scalable DNA sequencing approach by roll-to-roll fluidics.
Paper: www.nature.com/articles/s41...
nature.com/nmeth/volume...
On the cover, a cost-effective and scalable DNA sequencing approach by roll-to-roll fluidics.
Paper: www.nature.com/articles/s41...
PANCS-Binders (phage-assisted noncontinuous selection of protein binders) screens multiple high-diversity protein libraries against a panel of dozens of targets for high-throughput binder discovery. @chembiobryan.bsky.social @mstyles-chembiol.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 6, 2025 at 7:49 PM
PANCS-Binders (phage-assisted noncontinuous selection of protein binders) screens multiple high-diversity protein libraries against a panel of dozens of targets for high-throughput binder discovery. @chembiobryan.bsky.social @mstyles-chembiol.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The Platinum Pedigree offers a pedigree-derived benchmark for SNVs, indels, structural variants and tandem repeats. The resulting variant map will help validate sequencing workflows and support development of new variant callers.
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August 4, 2025 at 3:46 PM
The Platinum Pedigree offers a pedigree-derived benchmark for SNVs, indels, structural variants and tandem repeats. The resulting variant map will help validate sequencing workflows and support development of new variant callers.
www.nature.com/articles/s41...
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ProDomino is a machine learning-based method that predicts domain insertion sites and helps guide the engineering of functional multi-domain proteins.
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August 4, 2025 at 3:24 PM
ProDomino is a machine learning-based method that predicts domain insertion sites and helps guide the engineering of functional multi-domain proteins.
www.nature.com/articles/s41...
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Our latest Points of Significance column discusses symmetric alternatives to the ordinary least squares regression. @martin-krzywinski.bsky.social ky.social www.nature.com/articles/s41...-w
July 24, 2025 at 5:37 PM
Our latest Points of Significance column discusses symmetric alternatives to the ordinary least squares regression. @martin-krzywinski.bsky.social ky.social www.nature.com/articles/s41...-w
hCRAFi-CCR2 is a genetically encoded sensor that detects chemokine binding to the CCR2 receptor, demonstrated in cell culture and in mice. @piatkevich.bsky.social
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July 15, 2025 at 5:58 PM
hCRAFi-CCR2 is a genetically encoded sensor that detects chemokine binding to the CCR2 receptor, demonstrated in cell culture and in mice. @piatkevich.bsky.social
www.nature.com/articles/s41...
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Roll-to-roll fluidics enhances reagent efficiency and reduces turnaround time in next-generation DNA sequencing, while maintaining high precision and sensitivity.
www.nature.com/articles/s41...
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July 14, 2025 at 4:15 PM
Roll-to-roll fluidics enhances reagent efficiency and reduces turnaround time in next-generation DNA sequencing, while maintaining high precision and sensitivity.
www.nature.com/articles/s41...
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A new Registered Report presents a comprehensive benchmarking analysis of single-cell multi-modal data integration methods.
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July 11, 2025 at 2:03 PM
A new Registered Report presents a comprehensive benchmarking analysis of single-cell multi-modal data integration methods.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our July issue is live! nature.com/nmeth/volume...
On the cover, a method for predicting water molecules that are more or less displaceable by temperature or ligands provides a roadmap for ligand discovery.
Art by Madison Rice @stjuderesearch.bsky.social
Paper: www.nature.com/articles/s41...
On the cover, a method for predicting water molecules that are more or less displaceable by temperature or ligands provides a roadmap for ligand discovery.
Art by Madison Rice @stjuderesearch.bsky.social
Paper: www.nature.com/articles/s41...
July 11, 2025 at 1:48 PM
Our July issue is live! nature.com/nmeth/volume...
On the cover, a method for predicting water molecules that are more or less displaceable by temperature or ligands provides a roadmap for ligand discovery.
Art by Madison Rice @stjuderesearch.bsky.social
Paper: www.nature.com/articles/s41...
On the cover, a method for predicting water molecules that are more or less displaceable by temperature or ligands provides a roadmap for ligand discovery.
Art by Madison Rice @stjuderesearch.bsky.social
Paper: www.nature.com/articles/s41...
BEAST X advances Bayesian phylogenetic, phylogeographic and phylodynamic analysis by incorporating a broad range of complex models and leveraging advanced algorithms and techniques to boost statistical inference. www.nature.com/articles/s41...
July 7, 2025 at 10:33 PM
BEAST X advances Bayesian phylogenetic, phylogeographic and phylodynamic analysis by incorporating a broad range of complex models and leveraging advanced algorithms and techniques to boost statistical inference. www.nature.com/articles/s41...