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Nature Communications
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Nature Communications is an open access journal publishing high-quality research in all areas of the biological, physical, chemical, clinical, social, and Earth sciences.

www.nature.com/ncomms/
Drug-tolerant persisters #DTP, a rare subpopulation of cancer cells, can survive therapy via reversible non-genetic mechanisms. @seansi.bsky.social lab provide their #perspective on the gaps and research paths still needed to bridge basic DTP research with the clinic. www.nature.com/articles/s41...
November 19, 2025 at 3:24 PM
RUVBL1/2 regulation of KLF5 shown to modulate both classical and basal-like transcriptional lineage programs in pancreatic cancer. doi.org/10.1038/s414...
November 19, 2025 at 3:14 PM
Discovery that a preserved, DLD-mediated metabolic suppression by TGFβ undermines anti-TGFβ therapy, promoting gastric cancer growth. doi.org/10.1038/s414...
November 19, 2025 at 2:00 PM
Development of a classifier accurately predicting the origin sites for neuroendocrine neoplasms based on DNA methylation patterns, and showing that hepatic neuroendocrine neoplasms with unknown primary tumor are predicted to display a non-hepatic origin. doi.org/10.1038/s414...
November 11, 2025 at 1:00 PM
Sevellec et al. unveils temperature and salinity #Transformations along density surfaces from deep #OceanObservations. These #Transformations, which do not disturb the #OceanDynamics, are more important than their across density equivalents. #HiddenOceanCirculation
www.nature.com/articles/s41...
November 10, 2025 at 9:07 AM
Discovery that Munc13-4 promotes breast cancer immune evasion through regulation of PD-L1 sorting in exosomes doi.org/10.1038/s414...
October 23, 2025 at 11:08 AM
Discovery of ALKBH8 as a direct transcriptional target of β-catenin, and that it mediates intestinal tumorigenesis through regulation of the translation of KRAS in a codon-dependent manner. doi.org/10.1038/s414...
October 23, 2025 at 11:02 AM
"You’re at the beginning of your PhD, immersed in your main projects, when your supervisor comes to you with an idea: “Why don’t we try something on the side? Just a little side project”"

https://bit.ly/47hsblR
October 19, 2025 at 4:34 PM
"You’re at the beginning of your PhD, immersed in your main projects, when your supervisor comes to you with an idea: “Why don’t we try something on the side? Just a little side project”"

https://bit.ly/47bs62W
October 18, 2025 at 10:35 AM
New featured image on our homepage!
https://bit.ly/4q12LBk

In this paper, Kathryn Everson et al. explore lemur evolution using a phylogenomic dataset with broad taxonomic sampling, revealing patterns of speciation, extinction, & gene flow

https://bit.ly/4nfw8gU
October 14, 2025 at 4:31 PM
New study by Song et al. highlights a sharp #Warming contrast within the #SouthernOcean: the #Atlantic-Indian sector warms faster than the #Pacific due to #wind-driven heat transport. The contrast is projected to persist, shaping future climate and ocean change. www.nature.com/articles/s41...
October 14, 2025 at 6:57 AM
Report of a transgenic mouse model of renal tumorigenesis expressing the human SFPQ-TFE3 fusion, showing that the fusion regulates mTORC1 activity and induces lineage plasticity. doi.org/10.1038/s414...
October 9, 2025 at 12:49 PM
In vivo CRISPR-Cas9 screens identify that Uchl5 is involved in immune evasion and modulation of extracellular matrix deposition in head and neck squamous cell carcinoma doi.org/10.1038/s414...
October 2, 2025 at 4:37 PM
Diabetes-induced senescence of endothelial cells shown to promote pancreatic cancer progression doi.org/10.1038/s414...
October 2, 2025 at 4:35 PM
ICAM1 enhances glioblastoma stemness and promotes immune evasion through the β-catenin/PD-L1 signaling pathway doi.org/10.1038/s414...
October 2, 2025 at 4:31 PM
September 30, 2025 at 1:22 PM
September 27, 2025 at 1:23 PM
September 24, 2025 at 1:22 PM
📢 Epigenetics & epigenomics fans!
Meet our editor Dr P. Mallini in Brussels, Sept 24–26, 2025 for #Epigenetics2025
Hosted by Prof. François Fuks (ULB) & Xcells Conferences at Hotel Le Plaza.
Info & registration: xcellsconferences.com/epigenetics2025
September 10, 2025 at 2:28 PM
September 9, 2025 at 11:32 AM
Mechanical constriction in microcapillaries shown to reprogram melanoma cells to a tumorigenic stem cell-like state through the mechanosensor PIEZO1. doi.org/10.1038/s414...
September 8, 2025 at 10:56 AM
Franco et al. quantify the distinct impacts of #deforestation and #ClimateChange on the Brazilian #Amazon #rainforest. Deforestation amplifies the #temperature increase and dominates the decrease in #rainfall in the dry season. www.nature.com/articles/s41...
September 2, 2025 at 3:53 PM
Generation of a MYC-based gene circuitry that enhances immunotherapy response and tumor killing in bladder cancer. doi.org/10.1038/s414...
August 28, 2025 at 3:13 PM
Hypoxia upregulates RNA Polymerase I activity and ribosome biogenesis in breast cancer cells, and targeting RNA Polymerase I reduces tumor growth doi.org/10.1038/s414...
August 28, 2025 at 3:06 PM
Development of CRISPR-Cas9 knock-out, activation and repression screens in human gastric 3D organoids, also integrating single-cell CRISPR screens, to identify genes involved in the response to cisplatin in gastric cancer. doi.org/10.1038/s414...
August 25, 2025 at 7:35 AM