NanoImaging Services
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nanoimaging.bsky.social
NanoImaging Services
@nanoimaging.bsky.social
We are a cryoEM-focused US-based CRO (we own 3 microscopes on the West Coast, and 3 microscopes on the East Coast), and we acquired Proteos in Kalamazoo, MI, in January of this year. Contact us for cryoEM, gene-to-structure, or protein production.
🧪 Conflicting results from DLS? #CryoTEM imaging can provide quantitative and qualitative data for smaller particles, like iron nanoparticle formulations, all in one study. Reach out to [email protected] to learn how cryo-TEM imaging can help you meet milestones faster.
September 24, 2025 at 5:08 PM
🚀 Fast track your #HPV therapeutics with #cryoTEM imaging. From initial characterization to 3D structures, we support you throughout the entire pipeline, including regulatory submissions.

🧪 Want the proof? See our published work on Gardasil®: www.nanoimagingservices.com/resources/ho...
September 5, 2025 at 5:04 PM
How do you choose a nanoparticle characterization method? While there are many techniques available, cryo-TEM stands out by revealing information other methods miss.

Dive into the comparison: www.nanoimagingservices.com/about/blog/v...
August 5, 2025 at 6:02 PM
Ever wondered how buffers impact #cryoEM structures?

🧪 DMSO and cryoprotectants can be tolerated at low concentrations. If you're curious if your buffer will be compatible, schedule a call with our experts: www.nanoimagingservices.com/contact
August 1, 2025 at 3:27 PM
Are you looking for comprehensive, reliable particle sizing analysis? From LNPs to iron nanoparticles, cryo-TEM semi-automated particle contouring and sizing provides precise particle size distribution measurement for a range of samples.

Learn more at www.nanoimagingservices.com/nanoparticle...
July 22, 2025 at 5:04 PM
🧪 Ever wondered what the difference is between #cryoEM and #negativestain #TEM is? Find out in today's FAQ Friday!
July 18, 2025 at 2:47 PM
During a recent webinar, we were asked, “How does automated cryo-TEM particle picking for AAV full/empty capsids compare to other orthogonal methods?”

Watch the webinar in full for a great explanation of cryo-TEM imaging & analysis of AAV, and more of your great questions: youtu.be/w7kRfNZX_SI
July 7, 2025 at 6:02 PM
Poor contrast TEM images got you feeling grey? No problem!

Our latest tutorial will help you quickly & easily enhance the contrast and add scale bars to your #cryoTEM or negative stain TEM images so they’re ready for publication:
www.nanoimagingservices.com/about/blog/e...
June 25, 2025 at 6:03 PM
Have you signed up yet? In just 1 week, Dr. Mandy Janssen will be giving a webinar + Q&A diving into the applications of #cryoTEM for #LNP development!

Don't miss out on this deep dive: nimgs.zoom.us/webinar/regi...

Can't make it live? Sign up to get a recording, or send in your questions!
June 5, 2025 at 2:46 PM
FAQ Friday! Dr. Sarah Strassler Sulley touches on the differences between cryo-EM and HDX for epitop emapping.

Want more? Check out our blog with an in-depth technique comparison: www.nanoimagingservices.com/about/blog/e...
May 30, 2025 at 5:04 PM
How big are cryo-EM grids exactly? Find out!
May 16, 2025 at 5:02 PM
What are sample size requirements for Single Particle Analysis cryo-EM? Join Dr. Sarah Strassler Sulley to find out!

Questions about cryo-EM? Let us know!
April 18, 2025 at 5:02 PM
Did you know cryo-TEM is the only technique that can visualize blebbing on LNPs?

Check out our latest blog for detailed examples of blebs & bilayers, and a literature review: bit.ly/42oxkWH

Email us at [email protected] to get started imaging your lipid nanoparticles!
April 8, 2025 at 5:54 PM
It’s FAQ Friday! A well characterized sample can make all the difference for cryo-EM structure determination.

What characterization techniques do we recommend? Check in with Dr. Sarah Strassler Sulley to find out!

What else do you want to know about cryo-EM? Let us know.
April 4, 2025 at 5:05 PM
FAQ Friday! Have you ever wondered about the difference between Krios & Glacios microscopes? Find out now!

What #cryoEM questions do you have?
March 28, 2025 at 3:55 PM
Blebs on LNPs are mysterious & strange. Where do they come from? What impact do they have?

Scientist Brent Wood explores blebs & other morphological features of LNPs that can only be visualized with cryo-TEM.

Check out the images & literature review: www.nanoimagingservices.com/about/blog/t...
March 27, 2025 at 4:27 PM
Seeing unexpected results in your gene & drug delivery vehicles? Cryo-TEM imaging & analysis can help.

Automated, quantitative payload encapsulation analysis can accelerate your therapeutic pipeline and help inform efficacy and safety.

www.nanoimagingservices.com/nanoparticle...
March 19, 2025 at 5:19 PM
Cryo Electron Tomography can reveal the 3D structures of heterogeneous nanoparticles, such as liposomes, LNPs, exosomes, extracellular vesicles.

3D volumes can provide a complete picture of morphology, surface decorations, & internal composition.

Learn more: bit.ly/cryo-et
March 13, 2025 at 2:42 PM