Michael VanInsberghe
@mvanins.bsky.social
Reposted by Michael VanInsberghe
🧬 'Measuring translational dynamics by ribosome profiling' wrapped up yesterday! Huge thanks to the organisers, speakers, and participants who made it a success. Looking forward to continuing the work and seeing you all again soon! 🙌🏼 #EMBORiboProf
March 29, 2025 at 9:27 AM
🧬 'Measuring translational dynamics by ribosome profiling' wrapped up yesterday! Huge thanks to the organisers, speakers, and participants who made it a success. Looking forward to continuing the work and seeing you all again soon! 🙌🏼 #EMBORiboProf
Reposted by Michael VanInsberghe
Happy to share this concise review and outlook for single-cell sequencing methods to unravel cell biology of the nucleus! Big shoutout to my friend and former colleague Peter Zeller for sharing the work!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Shining a light on cell biology of the nucleus with single-cell sequencing
From the preservation of genomic integrity to the regulation of RNA translation, nearly all cellular processes are regulated in a cell context-depende…
www.sciencedirect.com
February 4, 2025 at 7:27 AM
Happy to share this concise review and outlook for single-cell sequencing methods to unravel cell biology of the nucleus! Big shoutout to my friend and former colleague Peter Zeller for sharing the work!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Michael VanInsberghe
Our paper is out! We delevoped a method to follow individual translating ribosomes for hours in living cells, and discovered that ribosomes are great friends and help each other in problematic situations:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
February 3, 2025 at 8:31 AM
Our paper is out! We delevoped a method to follow individual translating ribosomes for hours in living cells, and discovered that ribosomes are great friends and help each other in problematic situations:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Michael VanInsberghe
Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation
Ribosomes cooperate through transient collisions to ensure efficient translation.
www.cell.com
February 3, 2025 at 7:38 AM
Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Michael VanInsberghe
Very happy to share our preprint on visualizing the life cycle of Influenza viruses using single-molecule imaging! 🥳 We developed two techniques to visualize infections of unmodified influenza viruses in live cells from endosomal release to budding of new viruses. For more details&videos see below ⬇️
January 21, 2025 at 10:16 AM
Very happy to share our preprint on visualizing the life cycle of Influenza viruses using single-molecule imaging! 🥳 We developed two techniques to visualize infections of unmodified influenza viruses in live cells from endosomal release to budding of new viruses. For more details&videos see below ⬇️
Several new technologies have enabled translation profiling in single cells. In our article in @natrevmcb.bsky.social, Alexander and I discuss these single-cell methods for measuring ribosome profiles, ribosome-associated transcripts, and spatial translation 🧵 www.nature.com/articles/s41...
Sequencing technologies to measure translation in single cells - Nature Reviews Molecular Cell Biology
Recent sequencing-based methods, including novel ribosome profiling, ribosome affinity purification and spatial translation methods, have enabled the measurement of translation at single-cell resoluti...
www.nature.com
January 23, 2025 at 8:16 PM
Several new technologies have enabled translation profiling in single cells. In our article in @natrevmcb.bsky.social, Alexander and I discuss these single-cell methods for measuring ribosome profiles, ribosome-associated transcripts, and spatial translation 🧵 www.nature.com/articles/s41...