Thanks so much @thekinglab.bsky.social for the hospitality, delicious meal, and fun time chatting with you and your colleagues and trainees!

Proud to roll with this crew! 🤩 Celebrating our graduating students Varun, Lowell, and Tim! 🥳

We further unveil a novel therapeutic approach utilizing a first-in-class RSK inhibitor, PMD-026, that suppressed disease burden across syngeneic and PDX leukemia mouse models spanning the spectrum of driver and disease-modifying mutations.

Combining ATAC-Seq, CUT&Tag, RNA-seq, and CyTOF, we demonstrate that targeting of RSK1 suppresses NFκB activation and diminishes pro-inflammatory mediators including TNF associated with MPN disease severity and transformation.

Here we establish a comprehensive atlas across MPNs and secondary AML including RNA-sequencing of 158 primary samples encompassing CD34+ HPSCs and CD14+ monocytes. Supported by mass cytometry (CyTOF) profiling, we reveal aberrant PI3K/AKT/mTOR signaling and NFκB-mediated hyper-inflammation.

🎉 Happy Holidays from #OhLab #TeamMPN! 🎉 #familypic #holidayparty #BooCatClub #speakeasyafterparty

Was too busy with 🥳🍷🎉to take many pics but had so much fun at our WashU Hematology reception Friday evening especially co-hosting with great friend and collaborator Jorge Di Paola! #ASH24 @ash-hematology.bsky.social

Nice back 2 back talks & worlds colliding with new WashU faculty Helen Ajufo presenting her studies wifh Raajit Rampal and Jeff Zwicker + former WashU IM resident Joan How presenting GASTRO-MPN a collaborative effort including our faculty Kristen Sanfilippo! #ASH24 @ash-hematology.bsky.social

🤩 Wow wow wow #ASH24 attendees have 2x opportunities today to catch Molly Brakhane presenting her work today!

🏃🏃‍♀️🏃‍♂️Jog/run/sprint (don’t walk) to the poster walk at 11:15am featuring Molly’s poster.

And come to the poster session this evening (#1169)! 😁

@ash-hematology.bsky.social

Excited for this workshop this afternoon and grateful to the organizers Christina Glytsou, Panos Ntziachristos, & Dan Starczynowski for the opportunity to speak in the session alongside @gritsmanlab.bsky.social & Marek Mraz! #ASH24 #hemesky @ash-hematology.bsky.social
ash.confex.com/ash/2024/web...

Ready to board the WashU bus to #ASH24! @ash-hematology.bsky.social #hemesky

Stay tuned for our companion manuscript which we anticipate sharing soon 😀. Finally, check out my talk on this work at the #ASH24 Scientific Workshop on Therapy Resistance Mechanisms in Blood Malignancies!
@ash-hematology.bsky.social
ash.confex.com/ash/2024/web...

And congrats to co-winners of the George Broze Award for best oral presentation Aniruddha Samajdar & Molly Brakhane and best poster award to Joohyung Park!

Looking back at our recent Hematology Division Retreat featuring @aswolberg.bsky.social delivering the Evan Sadler lectureship + fantastic oral & poster presentations from our trainees and faculty! #hemesky

Excited for our MPN patient education event TONIGHT! 🩸 Even more excited to participate with Dr. Amy Zhou + added bonus of celebrating her b-day (a few days in advance) in clinic this morning! 🥳 Still time to register for in-person or virtual attendance!
tinyurl.com/mpn-with-dr-oh