Michael Meers
@mpmeers.bsky.social
Assistant Prof @WashUGenetics, chromatin-mediated regulation of development. Former postdoc @fredhutch, former grad student @UNC_Biology. Views my own.
The Meers Lab always follows protocols to the letter except when they don’t 🦁
October 22, 2025 at 12:21 AM
The Meers Lab always follows protocols to the letter except when they don’t 🦁
Given this is a Director's award, I'd be remiss to ignore the broader context of what the current NIH Director is presiding over right now at the NIH. These were my full thoughts when asked for a quote for this piece on what this means to me and our lab.
October 10, 2025 at 6:15 PM
Given this is a Director's award, I'd be remiss to ignore the broader context of what the current NIH Director is presiding over right now at the NIH. These were my full thoughts when asked for a quote for this piece on what this means to me and our lab.
Inspired by Derek Janssens' work on AutoCUT&RUN/Tag that streamlined those methods for highly parallel sample processing on a liquid handling robot, we simplified that a bit by allowing any user to process 96 samples at once without any specialized equipment, with a nice use case for AML 2/3
September 22, 2025 at 4:38 PM
Inspired by Derek Janssens' work on AutoCUT&RUN/Tag that streamlined those methods for highly parallel sample processing on a liquid handling robot, we simplified that a bit by allowing any user to process 96 samples at once without any specialized equipment, with a nice use case for AML 2/3
With apologies to @jeremymberg.bsky.social, I borrowed directly and heavily from this thread of his to craft my comment on this policy proposal, which I'm posting here for anyone who would like to use it as a template. Please heed Jeremy's exhortation and post a comment by Friday!
May 20, 2025 at 10:06 PM
With apologies to @jeremymberg.bsky.social, I borrowed directly and heavily from this thread of his to craft my comment on this policy proposal, which I'm posting here for anyone who would like to use it as a template. Please heed Jeremy's exhortation and post a comment by Friday!
We think about this Q a lot--as noted above, we used CUT&RUN fragment size to infer that some nuc binding probably occurs, but our thought is that these events are likely transient so won't be efficiently captured via a re-ChIP-style method. FWIW C&R shows ~20% nuc-sized frags for FOXA1 ⬇️
February 18, 2025 at 4:58 PM
We think about this Q a lot--as noted above, we used CUT&RUN fragment size to infer that some nuc binding probably occurs, but our thought is that these events are likely transient so won't be efficiently captured via a re-ChIP-style method. FWIW C&R shows ~20% nuc-sized frags for FOXA1 ⬇️
MRAF also met on Feb 10-11 after being posted Jan 13 (this one hurts because mine might easily have gone here instead of MRAA): www.federalregister.gov/documents/20...
February 18, 2025 at 4:06 PM
MRAF also met on Feb 10-11 after being posted Jan 13 (this one hurts because mine might easily have gone here instead of MRAA): www.federalregister.gov/documents/20...
You’re saying our president is refusing to meet his financial obligations?
January 28, 2025 at 4:01 AM
You’re saying our president is refusing to meet his financial obligations?
Today I sent a version of this letter to each of our senators from Missouri. Josh Hawley and Eric Schmitt, I trust you'll do the right thing.
January 20, 2025 at 3:47 PM
Today I sent a version of this letter to each of our senators from Missouri. Josh Hawley and Eric Schmitt, I trust you'll do the right thing.
This is actually really easy
January 19, 2025 at 4:40 PM
This is actually really easy
The future is now and it is confused 🤖❤️
January 19, 2025 at 3:27 PM
The future is now and it is confused 🤖❤️
Important update: Adriana photoshopped in Cass and Wilber since they didn't make it for the photo 😂
December 18, 2024 at 5:43 PM
Important update: Adriana photoshopped in Cass and Wilber since they didn't make it for the photo 😂
SWEET 🍪 REDEMPTION
The Meers lab are CHAMPIONS OF THE WORLD*
*of competitive gingerbread house-building @washugenetics.bsky.social
Clinched in GBBO style by finishing with one minute left, and inspired by the Climatron at Missouri Botanical Gardens 🪷
The Meers lab are CHAMPIONS OF THE WORLD*
*of competitive gingerbread house-building @washugenetics.bsky.social
Clinched in GBBO style by finishing with one minute left, and inspired by the Climatron at Missouri Botanical Gardens 🪷
December 18, 2024 at 4:49 PM
SWEET 🍪 REDEMPTION
The Meers lab are CHAMPIONS OF THE WORLD*
*of competitive gingerbread house-building @washugenetics.bsky.social
Clinched in GBBO style by finishing with one minute left, and inspired by the Climatron at Missouri Botanical Gardens 🪷
The Meers lab are CHAMPIONS OF THE WORLD*
*of competitive gingerbread house-building @washugenetics.bsky.social
Clinched in GBBO style by finishing with one minute left, and inspired by the Climatron at Missouri Botanical Gardens 🪷
We're a toddler! 👶 Two year labiversary featuring our now-customary pizza party🍕, cake made by Cass 🎂, drone-ball, and an interpretive human art installation reenacting how the lab keeps me afloat. Not a bad gig getting to do science with these folks 🧑🔬🧬
September 12, 2024 at 9:46 PM
We're a toddler! 👶 Two year labiversary featuring our now-customary pizza party🍕, cake made by Cass 🎂, drone-ball, and an interpretive human art installation reenacting how the lab keeps me afloat. Not a bad gig getting to do science with these folks 🧑🔬🧬
The OGR program at WashU links fantastic students from diverse backgrounds with genomics labs at WashU for an immersive mentored experience. More info: sites.wustl.edu/genomeresour... 2/2
September 11, 2024 at 8:36 PM
The OGR program at WashU links fantastic students from diverse backgrounds with genomics labs at WashU for an immersive mentored experience. More info: sites.wustl.edu/genomeresour... 2/2
Shout out to the Opportunities in Genomics Research (OGR) program at WashU for bringing us Ana Duke Cardenas as a summer undergrad designing TF reporter assays, and Adriana Ramirez who joins us for a postbac year supporting our cell line engineering efforts! 1/2
September 11, 2024 at 8:35 PM
Shout out to the Opportunities in Genomics Research (OGR) program at WashU for bringing us Ana Duke Cardenas as a summer undergrad designing TF reporter assays, and Adriana Ramirez who joins us for a postbac year supporting our cell line engineering efforts! 1/2
Well we didn't win the @WashUGenetics Gingerbread House building contest--you be the judge
December 19, 2023 at 2:54 PM
Well we didn't win the @WashUGenetics Gingerbread House building contest--you be the judge
A thread on our new Fellow to Faculty program @WashUGenetics, which builds a direct (and generous) pathway for stellar students/postdocs to become faculty in our department—I’m excited to be heavily involved in this along with @JimSkeath, @JessSFisher, and Tracey Hermanstyne. A few highlights: 1/6
November 27, 2023 at 6:24 PM
A thread on our new Fellow to Faculty program @WashUGenetics, which builds a direct (and generous) pathway for stellar students/postdocs to become faculty in our department—I’m excited to be heavily involved in this along with @JimSkeath, @JessSFisher, and Tracey Hermanstyne. A few highlights: 1/6
The lab really spruced up the neighborhood while I was gone! 📚
October 6, 2023 at 10:57 PM
The lab really spruced up the neighborhood while I was gone! 📚
Can’t begin to express my profound gratitude to each and every one of these people for making the first edition of the New Investigators in Chromatin and Epigenetics (NICE) conference so stellar! Particularly big 🙏 to my co-organizers @hainerlab.bsky.social and @4everBiochemist
October 4, 2023 at 8:10 PM
Can’t begin to express my profound gratitude to each and every one of these people for making the first edition of the New Investigators in Chromatin and Epigenetics (NICE) conference so stellar! Particularly big 🙏 to my co-organizers @hainerlab.bsky.social and @4everBiochemist
Crazy that I've been one year on the job already @WashUGenetics--here are some highlights from the lab pizza party to commemorate (not pictured: me getting worked in frisbee and cornhole). I've been falling behind on lab updates over the summer, so stay tuned for those!
September 18, 2023 at 2:44 PM
Crazy that I've been one year on the job already @WashUGenetics--here are some highlights from the lab pizza party to commemorate (not pictured: me getting worked in frisbee and cornhole). I've been falling behind on lab updates over the summer, so stay tuned for those!
Here's the official job ad:
September 14, 2023 at 7:44 PM
Here's the official job ad:
Come be my colleague! Our department
@WashUGenetics
is hiring tenure track faculty. Having been through the bewildering journey of the faculty job search recently, I know it can seem impenetrable at times, so please DM/email with any Qs. Job link here: t.co/XDIFE4L4Rc
@WashUGenetics
is hiring tenure track faculty. Having been through the bewildering journey of the faculty job search recently, I know it can seem impenetrable at times, so please DM/email with any Qs. Job link here: t.co/XDIFE4L4Rc
September 14, 2023 at 7:44 PM
Come be my colleague! Our department
@WashUGenetics
is hiring tenure track faculty. Having been through the bewildering journey of the faculty job search recently, I know it can seem impenetrable at times, so please DM/email with any Qs. Job link here: t.co/XDIFE4L4Rc
@WashUGenetics
is hiring tenure track faculty. Having been through the bewildering journey of the faculty job search recently, I know it can seem impenetrable at times, so please DM/email with any Qs. Job link here: t.co/XDIFE4L4Rc
BAF chromatin remodeler subunit BRG1 (SMARCA4) is another AMKL-specific DepMap vulnerability--Remarkably, BRG1 sits right at the CBF promoter, is enriched in MEPs, and a BRG/BRM inhibitor kills AMKL cell lines and increases survival in mice w/AMKL xenografts. 5/6
September 6, 2023 at 6:13 PM
BAF chromatin remodeler subunit BRG1 (SMARCA4) is another AMKL-specific DepMap vulnerability--Remarkably, BRG1 sits right at the CBF promoter, is enriched in MEPs, and a BRG/BRM inhibitor kills AMKL cell lines and increases survival in mice w/AMKL xenografts. 5/6