Maria Letizia Di Martino
@mldm.bsky.social
Senior Researcher at Uppsala University | Host-pathogen interactions | Intestinal organoids | Virulence gene regulation | Shigella and Salmonella | Functional genomics | Affiliated to the SellinLab @sellinlab.bsky.social
Huge thanks to Thibault Frisch, @sellinlab.bsky.social and all other co-authors and collaborators Petra Geiser, Margarita Κomi, Philip Karlsson, Anjeela Bhetwal, Laura Jenniches, @lbarquist.bsky.social , @holmqvist-lab.bsky.social , and @andrenmateus.bsky.social, for making this work possible!
November 21, 2025 at 11:30 AM
Huge thanks to Thibault Frisch, @sellinlab.bsky.social and all other co-authors and collaborators Petra Geiser, Margarita Κomi, Philip Karlsson, Anjeela Bhetwal, Laura Jenniches, @lbarquist.bsky.social , @holmqvist-lab.bsky.social , and @andrenmateus.bsky.social, for making this work possible!
This work builds on our recent Nature Genetics paper on Shigella colonization in intestinal organoids (rdcu.be/eqGgf), zooming in on one of the screen hits: pcnB.
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen
Nature Genetics - A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for...
rdcu.be
November 21, 2025 at 11:29 AM
This work builds on our recent Nature Genetics paper on Shigella colonization in intestinal organoids (rdcu.be/eqGgf), zooming in on one of the screen hits: pcnB.
Huge congratulations to Thibault Frisch for leading this work to completion with remarkable insight and drive, and thanks to all co-authors for making it happen! @sellinlab.bsky.social, @lbarquist.bsky.social, @andrenmateus.bsky.social, @holmqvist-lab.bsky.social
June 17, 2025 at 9:39 AM
Huge congratulations to Thibault Frisch for leading this work to completion with remarkable insight and drive, and thanks to all co-authors for making it happen! @sellinlab.bsky.social, @lbarquist.bsky.social, @andrenmateus.bsky.social, @holmqvist-lab.bsky.social
pcnB (poly-A polymerase I) sustains replication of the Shigella virulence plasmid at levels optimal for virulence and boosts intraepithelial expansion in intestinal organoid monolayers.
June 17, 2025 at 9:36 AM
pcnB (poly-A polymerase I) sustains replication of the Shigella virulence plasmid at levels optimal for virulence and boosts intraepithelial expansion in intestinal organoid monolayers.
Thank you so much!
June 13, 2025 at 11:35 AM
Thank you so much!
Stay tuned for a follow up story coming out soon!
June 12, 2025 at 4:12 PM
Stay tuned for a follow up story coming out soon!