Malcolm Sim
@mjwsim.bsky.social
Immunologist and group leader at University of Oxford.
https://www.immonc.ox.ac.uk/team/malcolm-sim-1
https://www.immonc.ox.ac.uk/team/malcolm-sim-1
Reposted by Malcolm Sim
Tomorrow we welcome Jonathon Worboys from the University of Manchester to our CIO seminar series.
Jon is a Wellcome research fellow and will give a talk titled ‘The nanoscale governance of TIGIT signalling and blockade’
Jon is a Wellcome research fellow and will give a talk titled ‘The nanoscale governance of TIGIT signalling and blockade’
November 26, 2025 at 10:36 AM
Tomorrow we welcome Jonathon Worboys from the University of Manchester to our CIO seminar series.
Jon is a Wellcome research fellow and will give a talk titled ‘The nanoscale governance of TIGIT signalling and blockade’
Jon is a Wellcome research fellow and will give a talk titled ‘The nanoscale governance of TIGIT signalling and blockade’
October 31, 2025 at 8:49 AM
Reposted by Malcolm Sim
Welcome DPhil class of 2025! Great to have you in CIO.
October 23, 2025 at 8:20 PM
Welcome DPhil class of 2025! Great to have you in CIO.
UK NK 2026 in Cardiff.
January 9th. Be there.
eventbrite.co.uk/e/uk-nk-confer…
Hosted by Rich Stanton, Ceri Fielding & Eddie Wang
January 9th. Be there.
eventbrite.co.uk/e/uk-nk-confer…
Hosted by Rich Stanton, Ceri Fielding & Eddie Wang
https://eventbrite.co.uk/e/uk-nk-confer…
October 23, 2025 at 8:53 AM
UK NK 2026 in Cardiff.
January 9th. Be there.
eventbrite.co.uk/e/uk-nk-confer…
Hosted by Rich Stanton, Ceri Fielding & Eddie Wang
January 9th. Be there.
eventbrite.co.uk/e/uk-nk-confer…
Hosted by Rich Stanton, Ceri Fielding & Eddie Wang
Delighted to be hosting the Oxford KIR Workshop 2026 April next year.
Please register here and contact me regarding accommodation.
www.oxforduniversitystores.co.uk/conferences-...
Please register here and contact me regarding accommodation.
www.oxforduniversitystores.co.uk/conferences-...
Oxford KIR Workshop 2026 | University of Oxford
An international gathering of scientists studying the killer-cell immunoglobulin-like receptors (KIR). It will cover topics such  evolution, immunogen
www.oxforduniversitystores.co.uk
October 22, 2025 at 2:45 PM
Delighted to be hosting the Oxford KIR Workshop 2026 April next year.
Please register here and contact me regarding accommodation.
www.oxforduniversitystores.co.uk/conferences-...
Please register here and contact me regarding accommodation.
www.oxforduniversitystores.co.uk/conferences-...
Any labs in Europe / US using Loderan products? Never heard of them but could save my lab a pretty penny
www.lorderan.com/en-gb/produc...
www.lorderan.com/en-gb/produc...
https://www.lorderan.com/en-gb/products/benchtop-80l-incubated-refrigerated-shaker
t.co
October 16, 2025 at 6:27 PM
Any labs in Europe / US using Loderan products? Never heard of them but could save my lab a pretty penny
www.lorderan.com/en-gb/produc...
www.lorderan.com/en-gb/produc...
Reposted by Malcolm Sim
Congratulations to new Nobel Laureate and AAI Distinguished Fellow Shimon Sakaguchi, co-winner of the 2025 Nobel Prize in Physiology or Medicine for his foundational discoveries on regulatory T cells and peripheral immune tolerance! Published in The JI in 1995: ow.ly/LGk150X7984.
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
Abstract. Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor α-chain (CD2
academic.oup.com
October 6, 2025 at 3:26 PM
Congratulations to new Nobel Laureate and AAI Distinguished Fellow Shimon Sakaguchi, co-winner of the 2025 Nobel Prize in Physiology or Medicine for his foundational discoveries on regulatory T cells and peripheral immune tolerance! Published in The JI in 1995: ow.ly/LGk150X7984.
Reposted by Malcolm Sim
Today we welcome Associate Prof. Amir Horowitz from the Tish Cancer Institute at Mt Sinai to the CIO Seminar Series.
Amir will present work from his group with the title 'Targeting HLA-E and NKG2A in solid tumors to overcome resistance to cancer immunotherapies'
Amir will present work from his group with the title 'Targeting HLA-E and NKG2A in solid tumors to overcome resistance to cancer immunotherapies'
October 3, 2025 at 8:33 AM
Today we welcome Associate Prof. Amir Horowitz from the Tish Cancer Institute at Mt Sinai to the CIO Seminar Series.
Amir will present work from his group with the title 'Targeting HLA-E and NKG2A in solid tumors to overcome resistance to cancer immunotherapies'
Amir will present work from his group with the title 'Targeting HLA-E and NKG2A in solid tumors to overcome resistance to cancer immunotherapies'
We're hiring!
Come join our lab in Oxford as a research assistant and study peptide recognition of MHC molecules - please reach our for more details!
www.jobs.ac.uk/job/DOW691/r...
Come join our lab in Oxford as a research assistant and study peptide recognition of MHC molecules - please reach our for more details!
www.jobs.ac.uk/job/DOW691/r...
Research Assistant at University of Oxford
An opportunity for an academic position as a Research Assistant is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.
www.jobs.ac.uk
October 1, 2025 at 12:44 PM
We're hiring!
Come join our lab in Oxford as a research assistant and study peptide recognition of MHC molecules - please reach our for more details!
www.jobs.ac.uk/job/DOW691/r...
Come join our lab in Oxford as a research assistant and study peptide recognition of MHC molecules - please reach our for more details!
www.jobs.ac.uk/job/DOW691/r...
Reposted by Malcolm Sim
🎨 After lunch we had some team-building fun with a sciency embossing workshop 🧑🎨 so many creative scientists in the room! Huge thanks to Asma for teaching us a new skill!! #CIOawayday #embossing
July 9, 2025 at 4:24 PM
🎨 After lunch we had some team-building fun with a sciency embossing workshop 🧑🎨 so many creative scientists in the room! Huge thanks to Asma for teaching us a new skill!! #CIOawayday #embossing
Reposted by Malcolm Sim
🧪 We continued with an engaging afternoon poster session featuring more of our talented PhD students 🐣 Fantastic science, thoughtful questions, and great discussions all around. The future is bright! #CIOawayday
July 9, 2025 at 4:29 PM
🧪 We continued with an engaging afternoon poster session featuring more of our talented PhD students 🐣 Fantastic science, thoughtful questions, and great discussions all around. The future is bright! #CIOawayday
Reposted by Malcolm Sim
🐣 We followed with our Junior PIs telling us about their questions for the next 5 years 💡 Lots of exciting, cutting-edge new ideas that will hopefully materialise soon and bring even more new questions to #CIO 🤓 🥳 #CIOawayday @galvez-cancino.bsky.social @mjwsim.bsky.social
July 9, 2025 at 12:20 PM
🐣 We followed with our Junior PIs telling us about their questions for the next 5 years 💡 Lots of exciting, cutting-edge new ideas that will hopefully materialise soon and bring even more new questions to #CIO 🤓 🥳 #CIOawayday @galvez-cancino.bsky.social @mjwsim.bsky.social
Reposted by Malcolm Sim
🌟 Fantastic morning poster session from our DPhil students 📚🧫 so much talent and fresh thinking on display! More to come this afternoon. #CIOawayday
July 9, 2025 at 12:03 PM
🌟 Fantastic morning poster session from our DPhil students 📚🧫 so much talent and fresh thinking on display! More to come this afternoon. #CIOawayday
Reposted by Malcolm Sim
✨ Kicking off #CIOawayday with our senior PIs sharing the experiments that changed their careers 🧑🔬👩🔬🧫 A reminder that serendipity, curiosity, and pub chats can spark groundbreaking ideas 🤓 Clearly science thrives on kindness and collaboration and we got a lot of that in #CIO 😉🙃 #ScienceLife
July 9, 2025 at 11:37 AM
✨ Kicking off #CIOawayday with our senior PIs sharing the experiments that changed their careers 🧑🔬👩🔬🧫 A reminder that serendipity, curiosity, and pub chats can spark groundbreaking ideas 🤓 Clearly science thrives on kindness and collaboration and we got a lot of that in #CIO 😉🙃 #ScienceLife
Reposted by Malcolm Sim
Atom-level mechanism of tapasin-independent peptide editing by Major Histocompatibility Complex class I molecules https://www.biorxiv.org/content/10.1101/2025.06.20.660712v1
June 25, 2025 at 9:16 PM
Atom-level mechanism of tapasin-independent peptide editing by Major Histocompatibility Complex class I molecules https://www.biorxiv.org/content/10.1101/2025.06.20.660712v1
Reposted by Malcolm Sim
Fascinating preprint from @timmunologist.bsky.social @mjwsim.bsky.social and co-authors
Atom-level mechanism of tapasin-independent peptide editing by Major Histocompatibility Complex class I molecules https://www.biorxiv.org/content/10.1101/2025.06.20.660712v1
June 26, 2025 at 7:31 AM
Fascinating preprint from @timmunologist.bsky.social @mjwsim.bsky.social and co-authors
Reposted by Malcolm Sim
Feeling proud and looking sharp!
Repping the Centre for Immuno-Oncology in style 😎
🔥Our top models, @anthonyhsieh.bsky.social and @mjwsim.bsky.social, rocking the CIO polos, in black and navy, which seems to be the unofficial Friday uniform around here!
Team spirit (and outfits) on point 💛🖤💙
Repping the Centre for Immuno-Oncology in style 😎
🔥Our top models, @anthonyhsieh.bsky.social and @mjwsim.bsky.social, rocking the CIO polos, in black and navy, which seems to be the unofficial Friday uniform around here!
Team spirit (and outfits) on point 💛🖤💙
June 20, 2025 at 12:06 PM
Feeling proud and looking sharp!
Repping the Centre for Immuno-Oncology in style 😎
🔥Our top models, @anthonyhsieh.bsky.social and @mjwsim.bsky.social, rocking the CIO polos, in black and navy, which seems to be the unofficial Friday uniform around here!
Team spirit (and outfits) on point 💛🖤💙
Repping the Centre for Immuno-Oncology in style 😎
🔥Our top models, @anthonyhsieh.bsky.social and @mjwsim.bsky.social, rocking the CIO polos, in black and navy, which seems to be the unofficial Friday uniform around here!
Team spirit (and outfits) on point 💛🖤💙
Reposted by Malcolm Sim
Lucy, FHS student at @mjwsim.bsky.social’s lab, has outdone herself! Not only is this the prettiest cake we’ve seen 😍, but it’s also seriously delicious 🤤🍰 #LabLife #BakingScience
June 19, 2025 at 11:08 AM
Lucy, FHS student at @mjwsim.bsky.social’s lab, has outdone herself! Not only is this the prettiest cake we’ve seen 😍, but it’s also seriously delicious 🤤🍰 #LabLife #BakingScience
Reposted by Malcolm Sim
And we're off!!
@timmunologist.bsky.social opens our third annual OCION Symposium @oxfordmathematics.bsky.social today!
Don't forget to visit our sponsors posters/exhibition stands.
@imtadvances.bsky.social (STAND)
@nanoporetech.com (STAND)
@Immunocore (POSTER)
@10xgenomics.bsky.social (STAND)
@timmunologist.bsky.social opens our third annual OCION Symposium @oxfordmathematics.bsky.social today!
Don't forget to visit our sponsors posters/exhibition stands.
@imtadvances.bsky.social (STAND)
@nanoporetech.com (STAND)
@Immunocore (POSTER)
@10xgenomics.bsky.social (STAND)
June 13, 2025 at 8:28 AM
And we're off!!
@timmunologist.bsky.social opens our third annual OCION Symposium @oxfordmathematics.bsky.social today!
Don't forget to visit our sponsors posters/exhibition stands.
@imtadvances.bsky.social (STAND)
@nanoporetech.com (STAND)
@Immunocore (POSTER)
@10xgenomics.bsky.social (STAND)
@timmunologist.bsky.social opens our third annual OCION Symposium @oxfordmathematics.bsky.social today!
Don't forget to visit our sponsors posters/exhibition stands.
@imtadvances.bsky.social (STAND)
@nanoporetech.com (STAND)
@Immunocore (POSTER)
@10xgenomics.bsky.social (STAND)
It’s Wednesday morning. There’s no more new Andor and I’m just supposed to carry on with my life.
May 21, 2025 at 5:17 AM
It’s Wednesday morning. There’s no more new Andor and I’m just supposed to carry on with my life.
Reposted by Malcolm Sim
Please sign this urgent petition to Parliament: #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK chng.it/tsH8ZSJfRH via
@ukchange.bsky.social
@ukchange.bsky.social
Sign the Petition
#StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK
chng.it
May 20, 2025 at 12:23 PM
Please sign this urgent petition to Parliament: #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK chng.it/tsH8ZSJfRH via
@ukchange.bsky.social
@ukchange.bsky.social
Reposted by Malcolm Sim
Delighted to share our review, published in Matrix Biology, led by Subashan Vadibeler, Shannique Clarke & Su Phyu - understanding matrix biology in oesophagogastric cancer is essential to improve therapeutic options, we highlight existing knowledge & gaps here - www.sciencedirect.com/science/arti...
Interactions between cancer-associated fibroblasts and the extracellular matrix in oesophageal cancer
Stromal components of the tumour microenvironment, such as cancer-associated fibroblasts (CAFs) and the extracellular matrix (ECM), are actively invol…
www.sciencedirect.com
May 20, 2025 at 11:50 AM
Delighted to share our review, published in Matrix Biology, led by Subashan Vadibeler, Shannique Clarke & Su Phyu - understanding matrix biology in oesophagogastric cancer is essential to improve therapeutic options, we highlight existing knowledge & gaps here - www.sciencedirect.com/science/arti...