Mirouse lab
@mirouse-lab.bsky.social
How to make the first cell of your life : an egg
Group leader at iGReD Clermont-Ferrand, Drosophila and cell biology, oogenesis and also a bit of muscle !
outdoor sports & comics
Group leader at iGReD Clermont-Ferrand, Drosophila and cell biology, oogenesis and also a bit of muscle !
outdoor sports & comics
Reposted by Mirouse lab
Sign up date coming quickly!
Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches
May 18-22, 2026 Roscoff, France
Abstract deadline: January 31, 2026
Apply here: cjm.sb-roscoff.fr/en
Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches
May 18-22, 2026 Roscoff, France
Abstract deadline: January 31, 2026
Apply here: cjm.sb-roscoff.fr/en
January 15, 2026 at 10:31 PM
Sign up date coming quickly!
Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches
May 18-22, 2026 Roscoff, France
Abstract deadline: January 31, 2026
Apply here: cjm.sb-roscoff.fr/en
Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches
May 18-22, 2026 Roscoff, France
Abstract deadline: January 31, 2026
Apply here: cjm.sb-roscoff.fr/en
Reposted by Mirouse lab
#art 🎨 | Quand l’art devient expérimental & que chaque spectateur devient 🧑🔬.
A l'occasion du spectacle 'Architectures vivantes’ du @museeorsay.bsky.social qui aura lieu les 24 et 25 janvier prochains, @manuelthery.bsky.social, directeur scientifique du projet revient sur cette expérimentation en 📽️
A l'occasion du spectacle 'Architectures vivantes’ du @museeorsay.bsky.social qui aura lieu les 24 et 25 janvier prochains, @manuelthery.bsky.social, directeur scientifique du projet revient sur cette expérimentation en 📽️
January 16, 2026 at 8:39 AM
#art 🎨 | Quand l’art devient expérimental & que chaque spectateur devient 🧑🔬.
A l'occasion du spectacle 'Architectures vivantes’ du @museeorsay.bsky.social qui aura lieu les 24 et 25 janvier prochains, @manuelthery.bsky.social, directeur scientifique du projet revient sur cette expérimentation en 📽️
A l'occasion du spectacle 'Architectures vivantes’ du @museeorsay.bsky.social qui aura lieu les 24 et 25 janvier prochains, @manuelthery.bsky.social, directeur scientifique du projet revient sur cette expérimentation en 📽️
Reposted by Mirouse lab
📣First preprint of the lab📣 Did that really happen?😅
Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes.
www.biorxiv.org/content/10.6...
Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes.
www.biorxiv.org/content/10.6...
Genetic sex of enteric neurons enables ovarian relaxin to gate maternal gut plasticity
Animals must align intestinal plasticity and feeding with reproductive state, yet the checkpoint that gates these adaptations is unknown. Here we show that an ovary-to-enteric-neuron axis gates the on...
www.biorxiv.org
January 11, 2026 at 3:32 PM
📣First preprint of the lab📣 Did that really happen?😅
Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes.
www.biorxiv.org/content/10.6...
Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes.
www.biorxiv.org/content/10.6...
Reposted by Mirouse lab
Happy New Year 2026!
This year, Hadi Boukhatmi, Régis Giet and I are delighted to be organising the 36th French Droso Meeting in Brittany, from 5 to 8 October.
A great line-up of speakers
Mark the date in your diaries !
The meeting website containing all the details will be opening very soon.
This year, Hadi Boukhatmi, Régis Giet and I are delighted to be organising the 36th French Droso Meeting in Brittany, from 5 to 8 October.
A great line-up of speakers
Mark the date in your diaries !
The meeting website containing all the details will be opening very soon.
January 6, 2026 at 9:24 AM
Happy New Year 2026!
This year, Hadi Boukhatmi, Régis Giet and I are delighted to be organising the 36th French Droso Meeting in Brittany, from 5 to 8 October.
A great line-up of speakers
Mark the date in your diaries !
The meeting website containing all the details will be opening very soon.
This year, Hadi Boukhatmi, Régis Giet and I are delighted to be organising the 36th French Droso Meeting in Brittany, from 5 to 8 October.
A great line-up of speakers
Mark the date in your diaries !
The meeting website containing all the details will be opening very soon.
Reposted by Mirouse lab
Call for papers
Submit your latest in vivo and in vitro #DevBio research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells
Guest Editors: Alex Hughes and Rashmi Priya
Deadline: 1 March 2026
journals.biologists.com/dev/pages/ex...
Submit your latest in vivo and in vitro #DevBio research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells
Guest Editors: Alex Hughes and Rashmi Priya
Deadline: 1 March 2026
journals.biologists.com/dev/pages/ex...
November 25, 2025 at 1:07 PM
Call for papers
Submit your latest in vivo and in vitro #DevBio research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells
Guest Editors: Alex Hughes and Rashmi Priya
Deadline: 1 March 2026
journals.biologists.com/dev/pages/ex...
Submit your latest in vivo and in vitro #DevBio research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells
Guest Editors: Alex Hughes and Rashmi Priya
Deadline: 1 March 2026
journals.biologists.com/dev/pages/ex...
Reposted by Mirouse lab
So excited to share this as a new junior PI:
My brand-new lab website! 🎉🪰🌀
www.bischofflab.com
Please pass it on to young, motivated researchers looking for PhD positions 😊
And for the #FluorescenceFriday community: don’t miss the SciArt Gallery!
#CellBio #DevBio #PhDjob #PhDposition #Science
My brand-new lab website! 🎉🪰🌀
www.bischofflab.com
Please pass it on to young, motivated researchers looking for PhD positions 😊
And for the #FluorescenceFriday community: don’t miss the SciArt Gallery!
#CellBio #DevBio #PhDjob #PhDposition #Science
November 27, 2025 at 8:26 AM
So excited to share this as a new junior PI:
My brand-new lab website! 🎉🪰🌀
www.bischofflab.com
Please pass it on to young, motivated researchers looking for PhD positions 😊
And for the #FluorescenceFriday community: don’t miss the SciArt Gallery!
#CellBio #DevBio #PhDjob #PhDposition #Science
My brand-new lab website! 🎉🪰🌀
www.bischofflab.com
Please pass it on to young, motivated researchers looking for PhD positions 😊
And for the #FluorescenceFriday community: don’t miss the SciArt Gallery!
#CellBio #DevBio #PhDjob #PhDposition #Science
Reposted by Mirouse lab
I am very excited to announce the opening of the submission site for the upcoming Conférences Jacques Monod on Developmental Biology, May 18-22, 2026 cjm.sb-roscoff.fr/en/conferenc...
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
October 23, 2025 at 12:49 PM
I am very excited to announce the opening of the submission site for the upcoming Conférences Jacques Monod on Developmental Biology, May 18-22, 2026 cjm.sb-roscoff.fr/en/conferenc...
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
Reposted by Mirouse lab
Want to join a happy bunch 🥳 to organise meetings, outreach activities and other initiatives about developmental biology in France? Apply and/or vote 🗳️!
🚨🚨🚨
The SFBD board needs to be renewed with 5 members
We wish to strengthen our board with young scientists
To apply: send a brief text introducing your research interests and motivations to [email protected] by December 4th
Elections will be held online from December 10th to 17th
Please share the info
The SFBD board needs to be renewed with 5 members
We wish to strengthen our board with young scientists
To apply: send a brief text introducing your research interests and motivations to [email protected] by December 4th
Elections will be held online from December 10th to 17th
Please share the info
November 10, 2025 at 12:00 PM
Want to join a happy bunch 🥳 to organise meetings, outreach activities and other initiatives about developmental biology in France? Apply and/or vote 🗳️!
Reposted by Mirouse lab
On the cover - Congrats @jeromeavellaneda.bsky.social @nunoluis.bsky.social
flies fly! @fly-eds.bsky.social www.cell.com/developmenta...
flies fly! @fly-eds.bsky.social www.cell.com/developmenta...
November 3, 2025 at 5:22 PM
On the cover - Congrats @jeromeavellaneda.bsky.social @nunoluis.bsky.social
flies fly! @fly-eds.bsky.social www.cell.com/developmenta...
flies fly! @fly-eds.bsky.social www.cell.com/developmenta...
Reposted by Mirouse lab
Is science too obsessed with metrics, large-scale projects & “blockbuster” outputs? Desai & Jun argued that preserving the "auteur" spirit of individual creativity, exploration and risk-taking is essential for maintaining the creativity that drew us into science in the 1st place.
November 3, 2025 at 2:50 AM
Is science too obsessed with metrics, large-scale projects & “blockbuster” outputs? Desai & Jun argued that preserving the "auteur" spirit of individual creativity, exploration and risk-taking is essential for maintaining the creativity that drew us into science in the 1st place.
Reposted by Mirouse lab
Glad to share our latest work showing that #drosophila epigenetic enzyme TET controls muscle development independently of its catalytic activity but prevents muscle aging in a catalytic-dependent manner!
Congratulations to Vincent and Emilie @igred.fr !
links.springernature.com/f/a/L1ogzL3H...
Congratulations to Vincent and Emilie @igred.fr !
links.springernature.com/f/a/L1ogzL3H...
TET exhibits enzymatic-independent and-dependent functions during Drosophila flight muscle development and aging - Skeletal Muscle
Background Enzymes of the Ten-Eleven Translocation family are responsible for 5-methylcytosine (5mC) oxidation and play a key role in regulating DNA demethylation during various developmental processe...
links.springernature.com
October 27, 2025 at 3:23 PM
Glad to share our latest work showing that #drosophila epigenetic enzyme TET controls muscle development independently of its catalytic activity but prevents muscle aging in a catalytic-dependent manner!
Congratulations to Vincent and Emilie @igred.fr !
links.springernature.com/f/a/L1ogzL3H...
Congratulations to Vincent and Emilie @igred.fr !
links.springernature.com/f/a/L1ogzL3H...
Reposted by Mirouse lab
Reposted by Mirouse lab
💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF
bit.ly/4gX6njF
Remote control of AMPK via extracellular adenosine controls tissue growth - Nature Cell Biology
Zhang et al. demonstrate that AMPK can be activated by signalling metabolite, adenosine, under non-stress conditions during Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly
October 4, 2025 at 2:32 PM
💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF
bit.ly/4gX6njF
Reposted by Mirouse lab
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
October 8, 2025 at 8:49 AM
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Reposted by Mirouse lab
Latest from ours: www.cell.com/cell-reports...
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
October 5, 2025 at 10:35 AM
Latest from ours: www.cell.com/cell-reports...
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
Reposted by Mirouse lab
You can read Mark's 2024 @dev-journal.bsky.social Review article here: doi.org/10.1242/dev....
40 years since the Heidelberg genetic screen that revolutionized developmental and cell biology
ABSTRACT. Our current understanding of the molecular basis of embryonic development and the shared machinery underlying this remarkable process has its roots in three papers published 40 years ago, wh...
doi.org
October 3, 2025 at 4:13 PM
You can read Mark's 2024 @dev-journal.bsky.social Review article here: doi.org/10.1242/dev....
Reposted by Mirouse lab
Excited to share our last paper describing how intestinal stem cell migration promotes gut regeneration!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Pvf1-Pvr-mediated crosstalk between trachea and gut guides intestinal stem cell migration to promote gut regeneration - Nature Communications
Adult stem cells often reside in specialized niches that they exit upon injury. Here they show that in Drosophila, after damage the gut-associated trachea produces the PDGF-VEGF-related ligand Pvf1, which acts as a guidance cue directing ISC migration toward injury sites.
www.nature.com
September 29, 2025 at 8:04 PM
Excited to share our last paper describing how intestinal stem cell migration promotes gut regeneration!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mirouse lab
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
September 22, 2025 at 6:27 PM
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Reposted by Mirouse lab
I have gotten a bit behind at sharing the lab’s latest work - this paper is now published - check it out! www.cell.com/cell-reports... Long story short: insulin is the major determinant of female fat storage, with a relatively minor effect on males.
September 20, 2025 at 1:39 PM
I have gotten a bit behind at sharing the lab’s latest work - this paper is now published - check it out! www.cell.com/cell-reports... Long story short: insulin is the major determinant of female fat storage, with a relatively minor effect on males.
Reposted by Mirouse lab
📣 New preprint: Mechanochemical feedback, tissue geometry & rigid-body dynamics initiate rotational migration in Drosophila via spontaneous chiral symmetry breaking. A mechanism generalizable to closed epithelia.
@sreejithsanthosh.bsky.social
biorxiv.org/content/10.1...
@sreejithsanthosh.bsky.social
biorxiv.org/content/10.1...
September 19, 2025 at 6:25 PM
📣 New preprint: Mechanochemical feedback, tissue geometry & rigid-body dynamics initiate rotational migration in Drosophila via spontaneous chiral symmetry breaking. A mechanism generalizable to closed epithelia.
@sreejithsanthosh.bsky.social
biorxiv.org/content/10.1...
@sreejithsanthosh.bsky.social
biorxiv.org/content/10.1...
Reposted by Mirouse lab
A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis!
Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)
Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)
September 18, 2025 at 8:32 PM
A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis!
Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)
Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)
Reposted by Mirouse lab
August 10, 2025 at 3:09 PM
Reposted by Mirouse lab
@cnrsecologie.bsky.social regrette profondément l'adoption de cette loi à la vision court-termiste & ses conséquences graves sur l’environnement, qui méprise santé & bien-être de la population & le rôle des espèces sauvages dans la prod. agricole. La communauté scientifique n'a pas été entendue.
Le Parlement a définitivement adopté mardi la proposition de loi agricole Duplomb-Menonville, comprenant entre autres une mesure décriée de réintroduction sous conditions d'un pesticide néonicotinoïde, et présentée comme une réponse à la colère agricole de 2024.
July 9, 2025 at 8:38 AM
@cnrsecologie.bsky.social regrette profondément l'adoption de cette loi à la vision court-termiste & ses conséquences graves sur l’environnement, qui méprise santé & bien-être de la population & le rôle des espèces sauvages dans la prod. agricole. La communauté scientifique n'a pas été entendue.
Reposted by Mirouse lab
Students (Master's/PhD), do not miss this fantastic Developmental Biology course of @sorbonne-universite.fr and @institutcurie.bsky.social - It is FREE and open to international students, however, room and board + travel are not included.
training.institut-curie.org/courses/deve...
training.institut-curie.org/courses/deve...
June 13, 2025 at 4:55 PM
Students (Master's/PhD), do not miss this fantastic Developmental Biology course of @sorbonne-universite.fr and @institutcurie.bsky.social - It is FREE and open to international students, however, room and board + travel are not included.
training.institut-curie.org/courses/deve...
training.institut-curie.org/courses/deve...
Reposted by Mirouse lab
Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
www.philanthropy.cam.ac.uk
June 3, 2025 at 6:23 PM
Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...