Michael Shiloh, MD, PhD
@michaelshiloh.bsky.social
Physician-scientist at UT Southwestern Medical Center (Infectious Diseases; Immunology; Microbiology; Neuroimmunology). All views my own.
Lab website: https://labs.utsouthwestern.edu/shiloh-lab
Lab website: https://labs.utsouthwestern.edu/shiloh-lab
Reposted by Michael Shiloh, MD, PhD
My alma mater is hiring a microbiologist! Assistant/Associate Prof. 👇👇
Assistant/Associate Professor, Microbiology and Molecular Genetics - McGovern Medical School in Texas, United States | Faculty & Physicians at UTHealth Houston
Apply for Assistant/Associate Professor, Microbiology and Molecular Genetics - McGovern Medical School job with UTHealth Houston in Texas, United States. Faculty & Physicians at UTHealth Houston
careers.uth.tmc.edu
August 17, 2025 at 11:54 AM
My alma mater is hiring a microbiologist! Assistant/Associate Prof. 👇👇
Congratulations to Kathryn Rahlwes and the rest of the team on the new preprint from our group. We identify USP15, a deubiquitinase, as a key brake on macrophage immunity to Mycobacterium tuberculosis (Mtb). Remove it, and macrophages control Mtb far more effectively.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Deubiquitinase USP15 restricts autophagy and macrophage immunity to Mycobacterium tuberculosis
Autophagy enables macrophages to degrade intracellular Mycobacterium tuberculosis (Mtb), and this defense depends on E3 ubiquitin ligases such as PARKIN and SMURF1, which tag Mtb-associated structures...
www.biorxiv.org
August 8, 2025 at 6:05 PM
Congratulations to Kathryn Rahlwes and the rest of the team on the new preprint from our group. We identify USP15, a deubiquitinase, as a key brake on macrophage immunity to Mycobacterium tuberculosis (Mtb). Remove it, and macrophages control Mtb far more effectively.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Congrats @samuelalvarez.bsky.social and the entire team on this work characterizing established (i.e. M cells) and new cells in the mucosal immune system! The new cells we named WISP cells as they are found in both adenoid and tonsils. Read the paper to find out so much more!
🚨 New paper out in Mucosal Immunology!
We used snRNA-seq + spatial validation to map human adenoids and found:
• Immature & mature M cells
• New interferon-responsive cells: WISP cells
• Key epithelial–immune interactions
Read it here 👉 doi.org/10.1016/j.mu...
#MucosalImmunology #MCells
We used snRNA-seq + spatial validation to map human adenoids and found:
• Immature & mature M cells
• New interferon-responsive cells: WISP cells
• Key epithelial–immune interactions
Read it here 👉 doi.org/10.1016/j.mu...
#MucosalImmunology #MCells
Redirecting
doi.org
July 31, 2025 at 10:17 PM
Congrats @samuelalvarez.bsky.social and the entire team on this work characterizing established (i.e. M cells) and new cells in the mucosal immune system! The new cells we named WISP cells as they are found in both adenoid and tonsils. Read the paper to find out so much more!
Reposted by Michael Shiloh, MD, PhD
Quantifying Dissemination of Antibiotic Resistance Genes in Air from a Dairy Farm and Swine Farm, led by PhD student David Kormos, now published! We found ARGs in a range of particle sizes, indicating potential for inhalation exposure and long-range transport.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Quantifying Dissemination of Antibiotic Resistance Genes in Air from a Dairy Farm and Swine Farm
Farms are a suspected source of dissemination of antibiotic resistance genes (ARGs) to the atmosphere, but their contribution remains poorly quantified. This study investigated the concentrations, emi...
pubs.acs.org
July 18, 2025 at 6:46 PM
Quantifying Dissemination of Antibiotic Resistance Genes in Air from a Dairy Farm and Swine Farm, led by PhD student David Kormos, now published! We found ARGs in a range of particle sizes, indicating potential for inhalation exposure and long-range transport.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Congrats to Dhananjay Naik from @tedpricethepainguy.bsky.social's lab at UT Dallas on their new preprint deeply characterizing the nociceptive activity of SL-1 on mouse & human neurons.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mycobacterium tuberculosis sulfolipid-1 (Sl-1) increases the excitability of mouse and human TRPV1-positive sensory neurons in a YM254890-reversible fashion
Cough is a hallmark sign of tuberculosis and key driver of transmission. While traditionally attributed to host-driven inflammation, we previously demonstrated that Mycobacterium tuberculosis lipid ex...
www.biorxiv.org
July 1, 2025 at 9:17 PM
Congrats to Dhananjay Naik from @tedpricethepainguy.bsky.social's lab at UT Dallas on their new preprint deeply characterizing the nociceptive activity of SL-1 on mouse & human neurons.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Enjoyed celebrating John Neff’s PhD graduation ceremony yesterday.
May 23, 2025 at 11:27 PM
Enjoyed celebrating John Neff’s PhD graduation ceremony yesterday.
🦠💨 Why do some TB strains make you cough more? Cough isn’t just an annoying sign and symptom of active tuberculosis - it’s one way that Mycobacterium tuberculosis spreads from person to person. 1/14
#Tuberculosis #CoughScience #Aerobiology #Neuroimmunology #Microbiology youtu.be/9qqHOKUXY5U?...
#Tuberculosis #CoughScience #Aerobiology #Neuroimmunology #Microbiology youtu.be/9qqHOKUXY5U?...
Coughs and sneezes travel farther than you think
YouTube video by Massachusetts Institute of Technology (MIT)
youtu.be
May 6, 2025 at 6:12 PM
🦠💨 Why do some TB strains make you cough more? Cough isn’t just an annoying sign and symptom of active tuberculosis - it’s one way that Mycobacterium tuberculosis spreads from person to person. 1/14
#Tuberculosis #CoughScience #Aerobiology #Neuroimmunology #Microbiology youtu.be/9qqHOKUXY5U?...
#Tuberculosis #CoughScience #Aerobiology #Neuroimmunology #Microbiology youtu.be/9qqHOKUXY5U?...
Celebrating the next PhD to leave the lab. Congratulations Dr. Neff. As per Shiloh lab tradition, John’s graduation cake represents Activity Based Proteomic Profiling with rock candy “proteins”.
March 28, 2025 at 9:20 PM
Celebrating the next PhD to leave the lab. Congratulations Dr. Neff. As per Shiloh lab tradition, John’s graduation cake represents Activity Based Proteomic Profiling with rock candy “proteins”.
Michael Oliver needs to be investigated for corruption. This is not a joke.
January 25, 2025 at 3:54 PM
Michael Oliver needs to be investigated for corruption. This is not a joke.
Reposted by Michael Shiloh, MD, PhD
Scientists and Physicians
I’m being serious here —at this precarious juncture, along with all other defensive and support strategies, it is important to seize the public narrative—high level investment and leadership in medical discovery and innovation is unabashedly patriotic!
USA! USA! USA!
I’m being serious here —at this precarious juncture, along with all other defensive and support strategies, it is important to seize the public narrative—high level investment and leadership in medical discovery and innovation is unabashedly patriotic!
USA! USA! USA!
January 24, 2025 at 12:53 PM
Scientists and Physicians
I’m being serious here —at this precarious juncture, along with all other defensive and support strategies, it is important to seize the public narrative—high level investment and leadership in medical discovery and innovation is unabashedly patriotic!
USA! USA! USA!
I’m being serious here —at this precarious juncture, along with all other defensive and support strategies, it is important to seize the public narrative—high level investment and leadership in medical discovery and innovation is unabashedly patriotic!
USA! USA! USA!
First ever “Great Shiloh Lab Bake Off” was a big success. Loaf cake/bread was the assignment. Congrats to all 6 bakers and thanks to the 3 judges. Bakes were judged anonymously and comments were kind but fair.
January 8, 2025 at 10:21 PM
First ever “Great Shiloh Lab Bake Off” was a big success. Loaf cake/bread was the assignment. Congrats to all 6 bakers and thanks to the 3 judges. Bakes were judged anonymously and comments were kind but fair.
Lab Secret Santa today was a big hit. Really enjoyed my gifts!
December 13, 2024 at 8:17 PM
Lab Secret Santa today was a big hit. Really enjoyed my gifts!
Reposted by Michael Shiloh, MD, PhD
And just like that, Ms. Monard leveled up to Dr. Monard! 🥳🎓 Proof that caffeine, stubbornness, and 0.05 p-values can work wonders.
Congratulations, Sarah! 🚀🔬 #PhDone
Congratulations, Sarah! 🚀🔬 #PhDone
December 2, 2024 at 4:25 PM
And just like that, Ms. Monard leveled up to Dr. Monard! 🥳🎓 Proof that caffeine, stubbornness, and 0.05 p-values can work wonders.
Congratulations, Sarah! 🚀🔬 #PhDone
Congratulations, Sarah! 🚀🔬 #PhDone
Sarah wrote an incredible thesis manuscript and presented a masterful defense. Kudos!
And just like that, Ms. Monard leveled up to Dr. Monard! 🥳🎓 Proof that caffeine, stubbornness, and 0.05 p-values can work wonders.
Congratulations, Sarah! 🚀🔬 #PhDone
Congratulations, Sarah! 🚀🔬 #PhDone
December 10, 2024 at 10:43 PM
Sarah wrote an incredible thesis manuscript and presented a masterful defense. Kudos!
Reposted by Michael Shiloh, MD, PhD
Believe it or not, GRC has told me we need more registered applicants or this meeting might not survive! Please don't let that happen if you can afford to attend 🙏
If you're interested in learning about the latest of fundamental mycobacteriology, sign up for #GRCMyco2025! Acceptances will start in September, check out the full program and please RT!
We're live with the program!
www.grc.org/biology-of-m...
www.grc.org/biology-of-m...
November 19, 2024 at 10:46 PM
Believe it or not, GRC has told me we need more registered applicants or this meeting might not survive! Please don't let that happen if you can afford to attend 🙏
It was a wonderful thesis defense and I'm glad I was able to participate! Congrats to Sarah and her mentorship team!
The PhD defense jury of Ms. Sarah Monard is hard at work preparing for tomorrow's big day...
Serious business requires serious sustenance, after all!
@michaelshiloh.bsky.social @sophiechauvet.bsky.social #JulieRibotNotonBlue @chrisverollet.bsky.social #GCLugoNotonBlue @ipbstoulouse.bsky.social
Serious business requires serious sustenance, after all!
@michaelshiloh.bsky.social @sophiechauvet.bsky.social #JulieRibotNotonBlue @chrisverollet.bsky.social #GCLugoNotonBlue @ipbstoulouse.bsky.social
December 10, 2024 at 10:37 PM
It was a wonderful thesis defense and I'm glad I was able to participate! Congrats to Sarah and her mentorship team!
Congratulations to Samuel Alvarez-Arguedas, our bioinformatics collaborators in Ted Price's lab and our clinical collaborators UTSW Medical Center on Sam's preprint describing the in depth transcriptional profiling of human adenoid cells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells
The nasal, oropharyngeal, and bronchial mucosa are primary contact points for airborne pathogens like Mycobacterium tuberculosis (Mtb), SARS-CoV-2, and influenza virus. While mucosal surfaces can func...
www.biorxiv.org
October 24, 2024 at 2:54 PM
Congratulations to Samuel Alvarez-Arguedas, our bioinformatics collaborators in Ted Price's lab and our clinical collaborators UTSW Medical Center on Sam's preprint describing the in depth transcriptional profiling of human adenoid cells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Congratulations to Vickie Ektnitphong on submission of her paper, with help from Beatriz Dias & Priscila Campos. We describe application of an "alveolus-on-a-chip" device for the study of alveolar infection by a model non-tuberculous mycobacteria, M. fortuitum.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
An alveolus lung-on-a-chip model of Mycobacterium fortuitum lung infection
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
September 2, 2024 at 6:18 PM
Congratulations to Vickie Ektnitphong on submission of her paper, with help from Beatriz Dias & Priscila Campos. We describe application of an "alveolus-on-a-chip" device for the study of alveolar infection by a model non-tuberculous mycobacteria, M. fortuitum.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A short read on post-infectious cough.
You’re not sick anymore—so why are you still coughing?
One theory posits that viral exposure makes receptors in our airways overly sensitive for a time after sickness.
www.nationalgeographic.com
January 25, 2024 at 6:33 PM
A short read on post-infectious cough.
Reposted by Michael Shiloh, MD, PhD
Addgene will no longer be using X, formerly Twitter. Instead, we'll be posting our 'microblogging' content here on Bluesky.
blog.addgene.org/addgene-is-s...
blog.addgene.org/addgene-is-s...
Addgene is Stopping Use of X (formerly Twitter)
Addgene will no longer be posting, monitoring, or responding to posts on X. You can find us as @addgene.bsky.social on Bluesky or as @addgene on Instagram, TikTok, Facebook, and LinkedIn.
blog.addgene.org
January 11, 2024 at 4:51 PM
Addgene will no longer be using X, formerly Twitter. Instead, we'll be posting our 'microblogging' content here on Bluesky.
blog.addgene.org/addgene-is-s...
blog.addgene.org/addgene-is-s...
Watching Arsenal play these days is about as painful and frustrating as watching the Eagles. Sigh.
January 7, 2024 at 6:23 PM
Watching Arsenal play these days is about as painful and frustrating as watching the Eagles. Sigh.
I’m sure this will be a fantastic meeting.
Happy 2024 to everyone! It's already getting real for me and @michaelglickman.bsky.social !
www.grc.org/biology-of-m...
www.grc.org/biology-of-m...
January 6, 2024 at 12:46 AM
I’m sure this will be a fantastic meeting.
The final version of Josephine's paper is now online at Journal of Clinical Investigation. Congrats again to all the authors.
www.jci.org/articles/vie...
www.jci.org/articles/vie...
JCI -
CDKL5 regulates p62-mediated selective autophagy and confers protection against neurotropic v...
www.jci.org
January 3, 2024 at 5:03 PM
The final version of Josephine's paper is now online at Journal of Clinical Investigation. Congrats again to all the authors.
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Reposted by Michael Shiloh, MD, PhD
New collaborative paper with Michaela Kress lab in Austria just published in iScience: www.cell.com/iscience/ful... If you are interested non-coding RNAs in human DRG neurons, this is the paper for you! Led by Max Zeidler in Michaela's lab and Diana Tavares-Ferreira in my lab + Jackson Brougher
NOCICEPTRA2.0 - a comprehensive ncRNA atlas of human native and iPSC-derived sensory neurons
Non-coding RNAs (ncRNAs) are pivotal in gene regulation during development and disease.
MicroRNAs have been extensively studied in neurogenesis. However, limited knowledge
exists about the development...
www.cell.com
November 30, 2023 at 6:33 PM
New collaborative paper with Michaela Kress lab in Austria just published in iScience: www.cell.com/iscience/ful... If you are interested non-coding RNAs in human DRG neurons, this is the paper for you! Led by Max Zeidler in Michaela's lab and Diana Tavares-Ferreira in my lab + Jackson Brougher
Check out this preprint by Lindsay Guzman in Carolyn Bertozzi’s lab on bioorthogonal labeling of Mtb phenolic glycolipid.
Bioorthogonal metabolic labeling of the virulence factor phenolic glycolipid in mycobacteria https://www.biorxiv.org/content/10.1101/2023.11.28.569059v1
Bioorthogonal metabolic labeling of the virulence factor phenolic glycolipid in mycobacteria https://www.biorxiv.org/content/10.1101/2023.11.28.569059v1
Surface lipids on pathogenic mycobacteria modulate infection outcomes by regulating host immune resp
www.biorxiv.org
December 1, 2023 at 3:36 AM
Check out this preprint by Lindsay Guzman in Carolyn Bertozzi’s lab on bioorthogonal labeling of Mtb phenolic glycolipid.