Mike Cohen
@michaelnadbio.bsky.social
Chemical biologist passionate about post-translational modifications (PTMs) and a keen interest in drug development. Professor at OHSU leading a team dedicated to unraveling the mysteries of PARPs and ADP-ribosylation.
Happy to have made a small contribution during my mini-sabbatical in @ladurner.bsky.social lab!
November 13, 2025 at 6:42 PM
Happy to have made a small contribution during my mini-sabbatical in @ladurner.bsky.social lab!
They demonstrate that a common PARP1 variant (V762) shifts talazoparib from a non-retentive (Type II) to an allosteric, pro-retention (Type I) mode, thereby boosting chromatin trapping and cancer cell killing. The finding makes a strong case for genotype-guided dosing in HRD cancer therapy.
November 13, 2025 at 6:42 PM
They demonstrate that a common PARP1 variant (V762) shifts talazoparib from a non-retentive (Type II) to an allosteric, pro-retention (Type I) mode, thereby boosting chromatin trapping and cancer cell killing. The finding makes a strong case for genotype-guided dosing in HRD cancer therapy.
Congrats Jeremy! Well-deserved!
July 10, 2025 at 2:15 AM
Congrats Jeremy! Well-deserved!
Exciting times in the fields of ADP-ribosylation and ubiquitylation!
July 9, 2025 at 4:15 PM
Exciting times in the fields of ADP-ribosylation and ubiquitylation!
This paper, coupled with an exciting new paper from @ahellab.bsky.social and the Van Der Heiden Van Noort groups: www.nature.com/articles/s41...
And our recent collaborative work with @jnpruneda.bsky.social team: www.biorxiv.org/content/10.1...
reveal RNF114 as a reader and writer of MARUbylation.
And our recent collaborative work with @jnpruneda.bsky.social team: www.biorxiv.org/content/10.1...
reveal RNF114 as a reader and writer of MARUbylation.
July 9, 2025 at 4:15 PM
This paper, coupled with an exciting new paper from @ahellab.bsky.social and the Van Der Heiden Van Noort groups: www.nature.com/articles/s41...
And our recent collaborative work with @jnpruneda.bsky.social team: www.biorxiv.org/content/10.1...
reveal RNF114 as a reader and writer of MARUbylation.
And our recent collaborative work with @jnpruneda.bsky.social team: www.biorxiv.org/content/10.1...
reveal RNF114 as a reader and writer of MARUbylation.
Very cool finding, Matt. Congrats!
June 25, 2025 at 4:18 AM
Very cool finding, Matt. Congrats!
Great seeing both of you!
June 20, 2025 at 9:27 AM
Great seeing both of you!
😂. Hopefully Proctor’s gym has been upgraded to include a post-game recovery room, with cold baths and compression gear-haha. Every time I go out and play my body’s reminding me I’m not 25 anymore!
June 8, 2025 at 9:13 PM
😂. Hopefully Proctor’s gym has been upgraded to include a post-game recovery room, with cold baths and compression gear-haha. Every time I go out and play my body’s reminding me I’m not 25 anymore!
Yeah, this was definitely a major milestone for her. Amazing come from behind victory!
June 8, 2025 at 12:15 AM
Yeah, this was definitely a major milestone for her. Amazing come from behind victory!