Michael Marty
@michaelmarty.bsky.social
Scientist, Mass Spec, Membrane Biochemistry, Lipids, Department of Chemistry, University of Texas at Austin, #Nanodiscs, #UniDec
For the 3 of you who are still reading, thanks to everyone who has used UniDec and passed along feedback. I'm grateful for you all!
November 25, 2025 at 7:24 PM
For the 3 of you who are still reading, thanks to everyone who has used UniDec and passed along feedback. I'm grateful for you all!
Also, you'll notice the loss of isotope mode in UniDec. I'm working on merging in IsoDec to create a true mixed-resolution algorithm. But, it's taking longer than I expected to get it. I figured I post this version for the bug fixes. Stay tuned for that later.
November 25, 2025 at 7:24 PM
Also, you'll notice the loss of isotope mode in UniDec. I'm working on merging in IsoDec to create a true mixed-resolution algorithm. But, it's taking longer than I expected to get it. I figured I post this version for the bug fixes. Stay tuned for that later.
I removed Agilent and Sciex data support in this version. The library we use hasn't been actively maintained. We tried to port our own version, but it was causing issues with admin access and getting flagged. Trying to get official support for both, but it's a long legal process. Bummer...
November 25, 2025 at 7:24 PM
I removed Agilent and Sciex data support in this version. The library we use hasn't been actively maintained. We tried to port our own version, but it was causing issues with admin access and getting flagged. Trying to get official support for both, but it's a long legal process. Bummer...
Pass on congrats from me! How all is well there!
September 27, 2025 at 12:42 AM
Pass on congrats from me! How all is well there!
In this case, we are in a temporary space that we can’t modify. Seems to me like the MS should also have its own breakers in that case. I’ve blown a fuse on the instrument from shorts in boards but I’ve never seen an MS trip a building circuit
August 11, 2025 at 1:07 PM
In this case, we are in a temporary space that we can’t modify. Seems to me like the MS should also have its own breakers in that case. I’ve blown a fuse on the instrument from shorts in boards but I’ve never seen an MS trip a building circuit
Awesome! Send me an email, and I'd be happy to meet up.
May 1, 2025 at 8:42 PM
Awesome! Send me an email, and I'd be happy to meet up.
If you want to try it out, IsoDec is bundled with UniDec, and there is a simple GUI for doing individual spectra and full files. For doing full top-down proteomics searches, we've bundled it into @metamorpheus.bsky.social, where it really shines!
February 21, 2025 at 4:00 PM
If you want to try it out, IsoDec is bundled with UniDec, and there is a simple GUI for doing individual spectra and full files. For doing full top-down proteomics searches, we've bundled it into @metamorpheus.bsky.social, where it really shines!
We ended up with something that worked pretty well, and John Pavek, a postdoc in the group, worked on getting it into a top-down proteomics workflow. It's not leaps and bounds beyond other tools, but it's a decent improvement that nicely balances speed, accuracy, and depth.
February 21, 2025 at 4:00 PM
We ended up with something that worked pretty well, and John Pavek, a postdoc in the group, worked on getting it into a top-down proteomics workflow. It's not leaps and bounds beyond other tools, but it's a decent improvement that nicely balances speed, accuracy, and depth.
For a long time, I've tried to get UniDec to work for isotopic data, but it never really panned out. After getting a grant from NSF to go after the problem, I spent the summer trying to train AI to assign isotopic cluster charge states.
February 21, 2025 at 4:00 PM
For a long time, I've tried to get UniDec to work for isotopic data, but it never really panned out. After getting a grant from NSF to go after the problem, I spent the summer trying to train AI to assign isotopic cluster charge states.