Mathias Girbig
@mgirbig.bsky.social
Evolutionary Biochemist and Structural Biologist. Postdoc at MPI Marburg. Interested in the Evolution of Eukaryotes and its Molecular Machinery.
Reposted by Mathias Girbig
A new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by
@JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...
@JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...
Origin of chaperone dependence and assembly complexity in Rubisco biogenesis
Molecular chaperones assist with the folding and assembly of protein clients. Consequently, they are essential to diverse cellular functions. In most aerobic photosynthetic organisms such as B-cyanoba...
www.biorxiv.org
September 24, 2025 at 7:53 PM
A new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by
@JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...
@JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...
Reposted by Mathias Girbig
Excited about #Ubiquitin and protein degradation?
Have a look at my recent talk at the @danafarber.bsky.social Targeted Protein Degradation Webinar Series now out on YouTube. Here, I talk about my recent publication (see Blue-torial below)
www.youtube.com/watch?v=Cpg0...
Have a look at my recent talk at the @danafarber.bsky.social Targeted Protein Degradation Webinar Series now out on YouTube. Here, I talk about my recent publication (see Blue-torial below)
www.youtube.com/watch?v=Cpg0...
July 9, 2025 at 8:13 AM
Excited about #Ubiquitin and protein degradation?
Have a look at my recent talk at the @danafarber.bsky.social Targeted Protein Degradation Webinar Series now out on YouTube. Here, I talk about my recent publication (see Blue-torial below)
www.youtube.com/watch?v=Cpg0...
Have a look at my recent talk at the @danafarber.bsky.social Targeted Protein Degradation Webinar Series now out on YouTube. Here, I talk about my recent publication (see Blue-torial below)
www.youtube.com/watch?v=Cpg0...
Reposted by Mathias Girbig
New paper from the lab from Sriram Garg in my group. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-...
A general substitution matrix for structural phylogenetics.
Abstract. Sequence-based maximum likelihood (ML) phylogenetics is a widely used method for inferring evolutionary relationships, which has illuminated the
academic.oup.com
June 11, 2025 at 2:01 PM
New paper from the lab from Sriram Garg in my group. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-...
Reposted by Mathias Girbig
@amoebadiscovery.bsky.social made an iteresting interview with me about #heliozoa and #centrohelids - I think these organisms are really important, understudied and gorgeous 😍 Also lots other intresting reading and beatiful pictures! #protistsonsky link: tinyurl.com/adiscovery1
March 28, 2025 at 7:38 AM
@amoebadiscovery.bsky.social made an iteresting interview with me about #heliozoa and #centrohelids - I think these organisms are really important, understudied and gorgeous 😍 Also lots other intresting reading and beatiful pictures! #protistsonsky link: tinyurl.com/adiscovery1
Reposted by Mathias Girbig
Super excited to share our latest work on deciphering the #Ubiquitin Code
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
Ubiquitin chains determine the fates of their modified proteins, including proteasomal
degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation
and deubiquitination at hi...
www.cell.com
March 24, 2025 at 2:54 PM
Super excited to share our latest work on deciphering the #Ubiquitin Code
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
Reposted by Mathias Girbig
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
March 21, 2025 at 3:16 PM
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
Reposted by Mathias Girbig
Excited to share our latest work, led by the incredible @automnenine.bsky.social (now an Ass. Prof. at Princeton)! We uncover key insights into the retrotransposition mechanisms of LINE-1 ORF2p, the enzyme responsible for writing a significant portion of our genome.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Structural mechanism of LINE-1 target-primed reverse transcription
Long interspersed element-1 (LINE-1) retrotransposons are the only active autonomous transposable elements in humans. They propagate by reverse transcribing their mRNA into new genomic locations by a ...
www.science.org
March 6, 2025 at 9:33 PM
Excited to share our latest work, led by the incredible @automnenine.bsky.social (now an Ass. Prof. at Princeton)! We uncover key insights into the retrotransposition mechanisms of LINE-1 ORF2p, the enzyme responsible for writing a significant portion of our genome.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Mathias Girbig
The Foldseek webserver for fast protein structure searches now features a Sankey tree taxonomy visualization and filter, allowing to subset hits by clades. Developed by my talented student @sunjaelee.bsky.social. Try it out!
🌐 search.foldseek.com
🌐 search.foldseek.com
January 17, 2025 at 12:33 PM
The Foldseek webserver for fast protein structure searches now features a Sankey tree taxonomy visualization and filter, allowing to subset hits by clades. Developed by my talented student @sunjaelee.bsky.social. Try it out!
🌐 search.foldseek.com
🌐 search.foldseek.com
Reposted by Mathias Girbig
Excited to share the (hard) work of @zawarshah.bsky.social in its final form: www.nature.com/articles/s41...
A lot of insights into RNA Polymerase selectivity at snRNAs promoters !! As these promoters are often used for heterologous expression of RNAs (ie guide RNAs), you better know how they work
A lot of insights into RNA Polymerase selectivity at snRNAs promoters !! As these promoters are often used for heterologous expression of RNAs (ie guide RNAs), you better know how they work
Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters - Nature Communications
The snRNA Activating Protein Complex (SNAPc) mediates snRNA transcription by RNA Pol II and III. Here, the authors have used cryo-EM to resolve the structure of the SNAPc-bound RNA Pol III pre-initiat...
www.nature.com
January 3, 2025 at 10:37 AM
Excited to share the (hard) work of @zawarshah.bsky.social in its final form: www.nature.com/articles/s41...
A lot of insights into RNA Polymerase selectivity at snRNAs promoters !! As these promoters are often used for heterologous expression of RNAs (ie guide RNAs), you better know how they work
A lot of insights into RNA Polymerase selectivity at snRNAs promoters !! As these promoters are often used for heterologous expression of RNAs (ie guide RNAs), you better know how they work
Reposted by Mathias Girbig
Exciting 3-year postdoc opportunity with @carter-lab.bsky.social within a programme aimed at identifying the links between microtubule motors and axonal cargos.
Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering
Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering
December 12, 2024 at 3:19 PM
Exciting 3-year postdoc opportunity with @carter-lab.bsky.social within a programme aimed at identifying the links between microtubule motors and axonal cargos.
Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering
Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering
Reposted by Mathias Girbig
We discovered 3 RNA families that form homo-oligomeric RNA-only complexes! Studying nature continues to expand my wildest imagination. Read about it: doi.org/10.1101/2024...
Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Rhiju Das, Wah Chiu
Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Rhiju Das, Wah Chiu
December 13, 2024 at 12:42 AM
We discovered 3 RNA families that form homo-oligomeric RNA-only complexes! Studying nature continues to expand my wildest imagination. Read about it: doi.org/10.1101/2024...
Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Rhiju Das, Wah Chiu
Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Rhiju Das, Wah Chiu
Reposted by Mathias Girbig
Excited to share our new work on the earliest steps of Pol-III transcription: We provide structural and kinetic insights into tRNA promoter engagement by yeast transcription factor TFIIIC !
Cool collaboration with the Müller and Eustermann Labs @embl.org !
academic.oup.com/nar/advance-...
Cool collaboration with the Müller and Eustermann Labs @embl.org !
academic.oup.com/nar/advance-...
Structural and kinetic insights into tRNA promoter engagement by yeast general transcription factor TFIIIC
Abstract. Transcription of transfer RNA (tRNA) genes by RNA polymerase (Pol) III requires the general transcription factor IIIC (TFIIIC), which recognizes
academic.oup.com
December 11, 2024 at 7:39 AM
Excited to share our new work on the earliest steps of Pol-III transcription: We provide structural and kinetic insights into tRNA promoter engagement by yeast transcription factor TFIIIC !
Cool collaboration with the Müller and Eustermann Labs @embl.org !
academic.oup.com/nar/advance-...
Cool collaboration with the Müller and Eustermann Labs @embl.org !
academic.oup.com/nar/advance-...
Reposted by Mathias Girbig
This is my first post here :) Our TFIIIC story continues with our latest work in NAR (academic.oup.com/nar/advance-...). Using cryo-EM and single-molecule fluorescence microscopy (smFM), we explored unanswered questions in our human TFIIIC structure. Want to see the updated TFIIIC structure?
December 11, 2024 at 10:35 AM
This is my first post here :) Our TFIIIC story continues with our latest work in NAR (academic.oup.com/nar/advance-...). Using cryo-EM and single-molecule fluorescence microscopy (smFM), we explored unanswered questions in our human TFIIIC structure. Want to see the updated TFIIIC structure?
Reposted by Mathias Girbig
First paper of our lab today @natureportfolio.bsky.social by Nussi!
We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!
@embl.org #RNAbiology #RNASky
t.co/a24Xxcxdo0
We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!
@embl.org #RNAbiology #RNASky
t.co/a24Xxcxdo0
December 4, 2024 at 8:53 PM
First paper of our lab today @natureportfolio.bsky.social by Nussi!
We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!
@embl.org #RNAbiology #RNASky
t.co/a24Xxcxdo0
We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!
@embl.org #RNAbiology #RNASky
t.co/a24Xxcxdo0
Reposted by Mathias Girbig
Really nice to see our latest work on Sox/POU origins covered in detail in the @washingtonpost.com by Kasha Patel, the 🦠choano-mouse🐁 is getting the love it deserves! www.washingtonpost.com/climate-envi...
Scientists just used genes from a microorganism and created a mouse
The team used these newly generated stem cells to help form a living, breathing mouse from a developing embryo.
www.washingtonpost.com
November 28, 2024 at 1:44 PM
Really nice to see our latest work on Sox/POU origins covered in detail in the @washingtonpost.com by Kasha Patel, the 🦠choano-mouse🐁 is getting the love it deserves! www.washingtonpost.com/climate-envi...
Reposted by Mathias Girbig
If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪
November 27, 2024 at 12:15 PM
If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪
Excited to share my first paper as a postdoc with @KaHochberg @mpi_marburg! We've made some fascinating discoveries about the evolution of animal stem cells in colab with @jauchr and @deMendoza_Alex. 🧬🔬
Link: www.nature.com/articles/s41... (1/n)
Link: www.nature.com/articles/s41... (1/n)
The emergence of Sox and POU transcription factors predates the origins of animal stem cells - Nature Communications
The pluripotency program is maintained by transcription factors from the Sox and POU families. Here they identify SOX and POU factors from unicellular relatives of animals and show that unicellular SO...
www.nature.com
November 15, 2024 at 3:57 PM
Excited to share my first paper as a postdoc with @KaHochberg @mpi_marburg! We've made some fascinating discoveries about the evolution of animal stem cells in colab with @jauchr and @deMendoza_Alex. 🧬🔬
Link: www.nature.com/articles/s41... (1/n)
Link: www.nature.com/articles/s41... (1/n)