Nasopharyngeal carcinoma (NPC) in endemic areas is strongly linked to Epstein-Barr virus (EBV) infection. EBV-specific immunoglobulin (Ig)A and IgG ti…

This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avo...

Hepatitis B virus (HBV) infection remains an important yet underaddressed public health issue in the US. The prevalence of chronic HBV in the US ranges between 0.5 and 2.5 million people (0.5% to 0.7%...

Background The most frequent transmission modes of blood-borne infections (BBI), including HIV, hepatitis B virus (HBV) and C (HCV), are well documented. South Africa, an HIV epicentre, with HBV endem...

Healthcare workers vs Hunger is an annual friendly competition between teams of healthcare workers to help relieve food insecurity.

DPH Commissioner Robbie Goldstein says the CDC is spreading vaccine misinformation that is "deeply troubling and even dangerous."

Hayden S Andrews, M.D, Meena Murthy, C.N.P, Benjamin T Davis, M.D; Anal cancer screening: a balanced approach is necessary, Clinical Infectious Diseases, ,

HIV-1 persists lifelong despite effective antiretroviral therapy, yet the mechanisms underlying this persistence remain incompletely understood. Recent work by Wei et al. and Gao et al. reveals that t...

Author summary The microorganisms that live in and on our bodies—collectively known as the microbiome—can influence our health in many ways, including how our immune system behaves and how susceptible...

The HIV epidemic remains a critical public health challenge in the Southern U.S., where barriers such as healthcare shortages, structural racism, and social determinants of health exacerbate dispariti...

AbstractBackground. There is a need to build public support for the conduct of HIV cure research. It is important to enhance the public understanding of HI

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IntroductionIt has previously been established that there is an increased incidence of mutations in the cystic fibrosis transmembrane regulator (CFTR) gene amongst patients with non-cystic fibrosis bronchiectasis (NCFB). With the advent of new highly effective CFTR modulators, specifically elexacaftor–tezacaftor–ivacaftor (ETI), we asked whether NCFB patients with a single ETI amenable mutation who do not meet the criteria for a diagnosis of cystic fibrosis (CF) would benefit from this therapy.MethodsWe assembled a retrospective cohort of patients (n=12) with a single CFTR mutation amenable to ETI treatment. Patients included in this cohort did not meet the diagnostic criteria for CF but presented with similar pulmonary symptoms and frequent exacerbations. Medical records were reviewed to determine the effects of ETI on clinical outcomes. Paired sample t-test for univariate analysis and multivariate linear mixed effect modeling for continuous and categorical variables were used to examine the impact of ETI therapy.ResultsImprovements in pulmonary symptoms were observed in all 12 patients (100%), and 11 patients (91.6%) expressed improvement in quality of life. Mean % predicted forced expiratory volume in 1 s improved significantly from 69.3% to 75.0% (p=0.007). Mean reported pulmonary symptoms decreased to 2.17 (p=0.007) and mean reported pulmonary exacerbations decreased to 1.08 per year (p=0.0006). When controlling for sweat chloride and Poly T insertions, post-ETI improvement remained significant.ConclusionAmongst patients presenting with NCFB and an amenable CFTR mutation, treatment with ETI improved lung function, symptoms and quality of life and led to a significant reduction in annual pulmonary exacerbations. Larger clinical studies are needed to further validate these findings.

Recent United States (US) immigration policies have left thousands of asylum seekers stranded in Mexican border cities with limited access to healthca…