George Davey Smith
@mendelrandom.bsky.social
Time expired epidemiologist
ALSPAC is known locally as Children of the Nineties, now tagging them @childrenofthe90s.bsky.social
The UKB 1/2 million (of which I am one) are indeed reasonably investigated, but in comparison to the ALSPAC cohort - who were recruited as foetuses and followed up into middle age - what I've had done in UKB is tiny. ALSPAC has 3 generations too. We need both study types! www.bristol.ac.uk/alspac/
November 21, 2025 at 11:44 AM
ALSPAC is known locally as Children of the Nineties, now tagging them @childrenofthe90s.bsky.social
The UKB 1/2 million (of which I am one) are indeed reasonably investigated, but in comparison to the ALSPAC cohort - who were recruited as foetuses and followed up into middle age - what I've had done in UKB is tiny. ALSPAC has 3 generations too. We need both study types! www.bristol.ac.uk/alspac/
November 21, 2025 at 10:27 AM
The UKB 1/2 million (of which I am one) are indeed reasonably investigated, but in comparison to the ALSPAC cohort - who were recruited as foetuses and followed up into middle age - what I've had done in UKB is tiny. ALSPAC has 3 generations too. We need both study types! www.bristol.ac.uk/alspac/
Reposted by George Davey Smith
“A better NHS is possible”; Starmer’s Labour Party has sadly forgotten this. A better Labour Party is also possible!
'Chaotic' and 'incoherent' - accusing unions of being cartels, looking to AI as the answer to all ills, and a 10 Year Plan that is at best a wish list.
A better NHS is possible. Join us at the @keepournhspublic.bsky.social primary care fight back on Nov 29th.
keepournhspublic.com/event/primar...
A better NHS is possible. Join us at the @keepournhspublic.bsky.social primary care fight back on Nov 29th.
keepournhspublic.com/event/primar...
Wes Streeting accused of ‘chaotic and incoherent approach’ to NHS reform
Exclusive: thinktank report finds health secretary has failed to improve productivity, with the health service unlikely to meet its targets
www.theguardian.com
November 15, 2025 at 2:15 PM
“A better NHS is possible”; Starmer’s Labour Party has sadly forgotten this. A better Labour Party is also possible!
“A better NHS is possible”; Starmer’s Labour Party has sadly forgotten this. A better Labour Party is also possible!
'Chaotic' and 'incoherent' - accusing unions of being cartels, looking to AI as the answer to all ills, and a 10 Year Plan that is at best a wish list.
A better NHS is possible. Join us at the @keepournhspublic.bsky.social primary care fight back on Nov 29th.
keepournhspublic.com/event/primar...
A better NHS is possible. Join us at the @keepournhspublic.bsky.social primary care fight back on Nov 29th.
keepournhspublic.com/event/primar...
Wes Streeting accused of ‘chaotic and incoherent approach’ to NHS reform
Exclusive: thinktank report finds health secretary has failed to improve productivity, with the health service unlikely to meet its targets
www.theguardian.com
November 15, 2025 at 2:15 PM
“A better NHS is possible”; Starmer’s Labour Party has sadly forgotten this. A better Labour Party is also possible!
Reposted by George Davey Smith
New paper on everyone’s favourite topic, QC!
We show why you should do genotype-level QC on your WGS data
www.biorxiv.org/content/10.1...
Very real quotes about this paper -
“The most exciting, mind-blowing paper of the year!”
“On a par with Fisher 1918”
“I read it every night. Just so beautiful”
We show why you should do genotype-level QC on your WGS data
www.biorxiv.org/content/10.1...
Very real quotes about this paper -
“The most exciting, mind-blowing paper of the year!”
“On a par with Fisher 1918”
“I read it every night. Just so beautiful”
Genotype-level quality control substantially reduces error rates in population-scale whole-genome sequencing
Population-scale whole-genome sequencing data will contain many individual-level genotype errors, even after allele-level quality control (QC). We establish the need for genotype-level QC using UK Bio...
www.biorxiv.org
November 8, 2025 at 9:31 AM
New paper on everyone’s favourite topic, QC!
We show why you should do genotype-level QC on your WGS data
www.biorxiv.org/content/10.1...
Very real quotes about this paper -
“The most exciting, mind-blowing paper of the year!”
“On a par with Fisher 1918”
“I read it every night. Just so beautiful”
We show why you should do genotype-level QC on your WGS data
www.biorxiv.org/content/10.1...
Very real quotes about this paper -
“The most exciting, mind-blowing paper of the year!”
“On a par with Fisher 1918”
“I read it every night. Just so beautiful”
Reposted by George Davey Smith
Congratulations to Richard Durbin on being awarded our Genetics Society Medal!
November 14, 2025 at 12:40 PM
Congratulations to Richard Durbin on being awarded our Genetics Society Medal!
Honoured to receive the 25th Anniversary MRC Millenium Medal. My mid-1980s epidemiological apprenticeship was at the MRC Epidemiology Unit in Cardiff in the mid-1980s, and my senescence with the MRC IEU, closing in March 2028
🙏 MRC!
@ukri.org @uob-ieu.bsky.social
www.ukri.org/news/mrc-mil...
🙏 MRC!
@ukri.org @uob-ieu.bsky.social
www.ukri.org/news/mrc-mil...
November 14, 2025 at 5:02 PM
Honoured to receive the 25th Anniversary MRC Millenium Medal. My mid-1980s epidemiological apprenticeship was at the MRC Epidemiology Unit in Cardiff in the mid-1980s, and my senescence with the MRC IEU, closing in March 2028
🙏 MRC!
@ukri.org @uob-ieu.bsky.social
www.ukri.org/news/mrc-mil...
🙏 MRC!
@ukri.org @uob-ieu.bsky.social
www.ukri.org/news/mrc-mil...
Finally in Navi Mumbai located my favourite beer since first coming to work in India in 1992, it is increasingly difficult to find, and now often only the STRONG ~8% “premium” version the only one available
November 1, 2025 at 9:47 AM
Finally in Navi Mumbai located my favourite beer since first coming to work in India in 1992, it is increasingly difficult to find, and now often only the STRONG ~8% “premium” version the only one available
Reposted by George Davey Smith
Reassuring to see a cow at a major road junction in Bangalore; after a third of a century of work trips to India most things have changed out of all recognition, but a silicon valley thriving bovine represents continuity
October 29, 2025 at 3:08 PM
Reassuring to see a cow at a major road junction in Bangalore; after a third of a century of work trips to India most things have changed out of all recognition, but a silicon valley thriving bovine represents continuity
Reassuring to see a cow at a major road junction in Bangalore; after a third of a century of work trips to India most things have changed out of all recognition, but a silicon valley thriving bovine represents continuity
October 29, 2025 at 3:08 PM
Reassuring to see a cow at a major road junction in Bangalore; after a third of a century of work trips to India most things have changed out of all recognition, but a silicon valley thriving bovine represents continuity
A special collection of 6 papers on cohort studies in China is just out in @bmj.com www.bmj.com/collections/...
with an editorial on the collection and the current publication climate www.bmj.com/collections/...
with an editorial on the collection and the current publication climate www.bmj.com/collections/...
Enhancing cohort studies in China and internationally
*/
www.bmj.com
October 28, 2025 at 9:51 AM
A special collection of 6 papers on cohort studies in China is just out in @bmj.com www.bmj.com/collections/...
with an editorial on the collection and the current publication climate www.bmj.com/collections/...
with an editorial on the collection and the current publication climate www.bmj.com/collections/...
Galton calling for data sharing in 1901 - does anyone know of earlier examples?
October 24, 2025 at 8:43 PM
Galton calling for data sharing in 1901 - does anyone know of earlier examples?
Are there earlier occurrences of groups being established to archive biological data to make them available for future analyses by researchers than this, which is from The British Association Committee on Biological Measurements, 1927?
October 24, 2025 at 10:45 AM
Are there earlier occurrences of groups being established to archive biological data to make them available for future analyses by researchers than this, which is from The British Association Committee on Biological Measurements, 1927?
Reposted by George Davey Smith
Fantastic opportunity to lead the Equity Lab @wellcometrust.bsky.social working with the legendary Jimmy Volmink, details here wellcome.wd3.myworkdayjobs.com/en-GB/Wellco... Please repost so as many as possible can see this great opportunity
Associate Director, Equity Lab
Salary: £120,800 Closing date: 9th November Contract type: Permanent Interview dates: 24th and 28th November The Wellcome Trust is a global charitable foundation. We improve health for everyone by fun...
wellcome.wd3.myworkdayjobs.com
October 23, 2025 at 11:12 PM
Fantastic opportunity to lead the Equity Lab @wellcometrust.bsky.social working with the legendary Jimmy Volmink, details here wellcome.wd3.myworkdayjobs.com/en-GB/Wellco... Please repost so as many as possible can see this great opportunity
Fantastic opportunity to lead the Equity Lab @wellcometrust.bsky.social working with the legendary Jimmy Volmink, details here wellcome.wd3.myworkdayjobs.com/en-GB/Wellco... Please repost so as many as possible can see this great opportunity
Associate Director, Equity Lab
Salary: £120,800 Closing date: 9th November Contract type: Permanent Interview dates: 24th and 28th November The Wellcome Trust is a global charitable foundation. We improve health for everyone by fun...
wellcome.wd3.myworkdayjobs.com
October 23, 2025 at 11:12 PM
Fantastic opportunity to lead the Equity Lab @wellcometrust.bsky.social working with the legendary Jimmy Volmink, details here wellcome.wd3.myworkdayjobs.com/en-GB/Wellco... Please repost so as many as possible can see this great opportunity
Reposted by George Davey Smith
Met @mendelrandom.bsky.social at a pub in Bristol after my talk yesterday to chat about causality, ratio variables, and the state of Epidemiology in Europe.
Behind him, on the bookshelf, was an old copy of Mendel's Principles of Heredity. A remarkable coincidence that required a photograph!
Behind him, on the bookshelf, was an old copy of Mendel's Principles of Heredity. A remarkable coincidence that required a photograph!
October 23, 2025 at 8:36 AM
Met @mendelrandom.bsky.social at a pub in Bristol after my talk yesterday to chat about causality, ratio variables, and the state of Epidemiology in Europe.
Behind him, on the bookshelf, was an old copy of Mendel's Principles of Heredity. A remarkable coincidence that required a photograph!
Behind him, on the bookshelf, was an old copy of Mendel's Principles of Heredity. A remarkable coincidence that required a photograph!
Reposted by George Davey Smith
TOMORROW IN BRISTOL!
"Have DAGs fulfilled their promise in epidemiology and health research?"
📆 22 October
⏰ 13:00 - 14:00
📍Queens Building, 1.18LT at the University of Bristol
Cc @bristoltarg.bsky.social @uob-ieu.bsky.social @mendelrandom.bsky.social @garethjgriffith.bsky.social
"Have DAGs fulfilled their promise in epidemiology and health research?"
📆 22 October
⏰ 13:00 - 14:00
📍Queens Building, 1.18LT at the University of Bristol
Cc @bristoltarg.bsky.social @uob-ieu.bsky.social @mendelrandom.bsky.social @garethjgriffith.bsky.social
October 21, 2025 at 9:01 AM
TOMORROW IN BRISTOL!
"Have DAGs fulfilled their promise in epidemiology and health research?"
📆 22 October
⏰ 13:00 - 14:00
📍Queens Building, 1.18LT at the University of Bristol
Cc @bristoltarg.bsky.social @uob-ieu.bsky.social @mendelrandom.bsky.social @garethjgriffith.bsky.social
"Have DAGs fulfilled their promise in epidemiology and health research?"
📆 22 October
⏰ 13:00 - 14:00
📍Queens Building, 1.18LT at the University of Bristol
Cc @bristoltarg.bsky.social @uob-ieu.bsky.social @mendelrandom.bsky.social @garethjgriffith.bsky.social
Reposted by George Davey Smith
For the tech bros who are intending to live forever it must be a shock to hear the big crunch is gonna end it all in 20 billion years .. they'll still be in middle age then www.sciencealert.com/physicists-p...
Physicists Predict When The Universe Will End in a Reverse Big Bang
If recent discoveries that dark energy is evolving hold any water, our Universe will collapse under its own gravity on a finite timeline, new calculations suggest.
www.sciencealert.com
October 11, 2025 at 11:27 PM
For the tech bros who are intending to live forever it must be a shock to hear the big crunch is gonna end it all in 20 billion years .. they'll still be in middle age then www.sciencealert.com/physicists-p...
For the tech bros who are intending to live forever it must be a shock to hear the big crunch is gonna end it all in 20 billion years .. they'll still be in middle age then www.sciencealert.com/physicists-p...
Physicists Predict When The Universe Will End in a Reverse Big Bang
If recent discoveries that dark energy is evolving hold any water, our Universe will collapse under its own gravity on a finite timeline, new calculations suggest.
www.sciencealert.com
October 11, 2025 at 11:27 PM
For the tech bros who are intending to live forever it must be a shock to hear the big crunch is gonna end it all in 20 billion years .. they'll still be in middle age then www.sciencealert.com/physicists-p...
Reposted by George Davey Smith
Do you have heavy or painful menstrual periods? If so, please consider filling in our short survey so that we can better understand how these symptoms interact with mental health and wellbeing. exe.qualtrics.com/jfe/form/SV_...
Is There a Link Between Heavy Menstrual Bleeding, Menstrual Pain, and Mental Health?
We are exploring how people experience heavy menstrual bleeding and menstrual pain, and how these experiences interact with their mental health. We want to better understand how these issues affect ea...
exe.qualtrics.com
September 26, 2025 at 6:11 PM
Do you have heavy or painful menstrual periods? If so, please consider filling in our short survey so that we can better understand how these symptoms interact with mental health and wellbeing. exe.qualtrics.com/jfe/form/SV_...
Just replace dark chocolate for whatever the nutritional exposure in today's news story is in the below ieureka.blogs.bristol.ac.uk/2024/12/04/d...
September 25, 2025 at 5:00 PM
Just replace dark chocolate for whatever the nutritional exposure in today's news story is in the below ieureka.blogs.bristol.ac.uk/2024/12/04/d...
Great to have @markmccarthy985.bsky.social at @uob-ieu.bsky.social giving a seminar tomorrow (Friday) at 12.30 online or in person www.bristol.ac.uk/integrative-...
September 25, 2025 at 4:57 PM
Great to have @markmccarthy985.bsky.social at @uob-ieu.bsky.social giving a seminar tomorrow (Friday) at 12.30 online or in person www.bristol.ac.uk/integrative-...
Reposted by George Davey Smith
Apply to do a PhD with me, Laura Corbin, Gareth Hawkes and George Davey Smith ( @mendelrandom.bsky.social) in Bristol on identifying rare effects on health using new and innovative methods. Amazing team, great educational environment, lovely city. Forward to your undergrads wrapping up!
Shining a light on the un-common to identify novel health risk-factors - GW4 BioMed MRC DTP
Project Code MRCPHS26Br Nivard Project Type Dry lab Research Theme Population Health Science Project Summary Download Summary Complex traits such as body mass index and height are influenced by a mixt...
gw4biomed.ac.uk
September 19, 2025 at 7:46 AM
Apply to do a PhD with me, Laura Corbin, Gareth Hawkes and George Davey Smith ( @mendelrandom.bsky.social) in Bristol on identifying rare effects on health using new and innovative methods. Amazing team, great educational environment, lovely city. Forward to your undergrads wrapping up!
"Triangulation: moving from correlations to causation", Cambridge School of Clinical Medicine Distinguished Lecture 2025, Thursday, October 16th, 5pm, in person or online
www.eventbrite.co.uk/e/school-of-...
www.eventbrite.co.uk/e/school-of-...
September 12, 2025 at 4:19 PM
"Triangulation: moving from correlations to causation", Cambridge School of Clinical Medicine Distinguished Lecture 2025, Thursday, October 16th, 5pm, in person or online
www.eventbrite.co.uk/e/school-of-...
www.eventbrite.co.uk/e/school-of-...
Reposted by George Davey Smith
Mendelian randomization (MR) was partly a response to the many epidemiological studies suggesting vitamins were protective against various diseases, only for randomised trials to be null. The story of how fallacious MR attempted to resurrect the spurious claims here academic.oup.com/ije/article/...
Erroneous epidemiological findings on vitamins: coming full circle after two decades of Mendelian randomization?
Our editorial responsibility for the International Journal of Epidemiology (IJE) started at the dawn of the current millennium, and we marked the occasion
academic.oup.com
September 11, 2025 at 1:47 PM
Mendelian randomization (MR) was partly a response to the many epidemiological studies suggesting vitamins were protective against various diseases, only for randomised trials to be null. The story of how fallacious MR attempted to resurrect the spurious claims here academic.oup.com/ije/article/...