Árni Freyr Gunnarsson
@meistarafugl.bsky.social
Reposted by Árni Freyr Gunnarsson
I wrote about how population stratification in genetic analyses led to a decade of false findings and almost certainly continues to bias emerging results. But we are starting to have statistical tools to sniff it out. A 🧵:
How population stratification led to a decade of sensationally false genetic findings
Stratification makes environments look like genes
open.substack.com
March 28, 2025 at 9:54 PM
I wrote about how population stratification in genetic analyses led to a decade of false findings and almost certainly continues to bias emerging results. But we are starting to have statistical tools to sniff it out. A 🧵:
Really nice application of ARGs here to phantom epistasis, which can arise due to "unobserved" mutations. These have already been shown to be useful in association studies
Phantom epistasis through the lens of genealogies https://www.biorxiv.org/content/10.1101/2024.12.03.626630v1
December 11, 2024 at 11:38 AM
Really nice application of ARGs here to phantom epistasis, which can arise due to "unobserved" mutations. These have already been shown to be useful in association studies