Mikala Egeblad
@megeblad.bsky.social
Bloomberg Distinguished Professor of Tumor Microenvironment. Johns Hopkins University School of Medicine.
Spring 2009 I opened my lab and accepted two @cshlnews.bsky.social rotation students now reunited at #AACR25: University of Hawaii Cancer Center clinician-scientist Elizabeth Nakasone, and Mount Sinai assistant professor and @theaacr.bsky.social NextGen Star @elvinwag.bsky.social - Made my day!
April 29, 2025 at 5:03 PM
Spring 2009 I opened my lab and accepted two @cshlnews.bsky.social rotation students now reunited at #AACR25: University of Hawaii Cancer Center clinician-scientist Elizabeth Nakasone, and Mount Sinai assistant professor and @theaacr.bsky.social NextGen Star @elvinwag.bsky.social - Made my day!
Pierina Barturen-Larrea gave the final talk, on acoustic reporter genes for In Situ Monitoring of Metastasis - or “luciferase” for ultrasound.
Last photo from the gilded conference hall! Thxs to speakers, chairs, poster presenters, and participants for wonderful presentations and discussions.
Last photo from the gilded conference hall! Thxs to speakers, chairs, poster presenters, and participants for wonderful presentations and discussions.
January 22, 2025 at 3:09 AM
Pierina Barturen-Larrea gave the final talk, on acoustic reporter genes for In Situ Monitoring of Metastasis - or “luciferase” for ultrasound.
Last photo from the gilded conference hall! Thxs to speakers, chairs, poster presenters, and participants for wonderful presentations and discussions.
Last photo from the gilded conference hall! Thxs to speakers, chairs, poster presenters, and participants for wonderful presentations and discussions.
@danielheller.bsky.social presented exciting data using a nano-particle formulation to get a drug against medullablastoma across the blood-brain barrier - where it needs to go - and away from cells in the growth plates where it can have devastating effects.
#KSMetastasis25
#KSMetastasis25
January 22, 2025 at 1:47 AM
@danielheller.bsky.social presented exciting data using a nano-particle formulation to get a drug against medullablastoma across the blood-brain barrier - where it needs to go - and away from cells in the growth plates where it can have devastating effects.
#KSMetastasis25
#KSMetastasis25
Ronit Satchi-Fainar presented on using 4DCanPredict platform to identify p-selectin as a critical target in brain cancer - leading to clinical trial NCT05909618.
#KSMetastasis25
#KSMetastasis25
January 22, 2025 at 1:10 AM
Ronit Satchi-Fainar presented on using 4DCanPredict platform to identify p-selectin as a critical target in brain cancer - leading to clinical trial NCT05909618.
#KSMetastasis25
#KSMetastasis25
Edgar Engleman presented work on tumor immune tolerance - and importantly how to overcome it, including a novel mechanism involving dendritic cells.
#KSMetastasis25
#KSMetastasis25
January 22, 2025 at 12:40 AM
Edgar Engleman presented work on tumor immune tolerance - and importantly how to overcome it, including a novel mechanism involving dendritic cells.
#KSMetastasis25
#KSMetastasis25
The views are as as spectacular as the science. The sun is setting over Banff as we are about to start the last session of #KSMetastasis25.
January 21, 2025 at 11:54 PM
The views are as as spectacular as the science. The sun is setting over Banff as we are about to start the last session of #KSMetastasis25.
Graduate student Mary Clare Beytagh ended the Spotlight session, presenting on a new hiPSC-marked model of group 3 medullablastoma. She is using the system to identify drivers of leptomeningeal metastasis.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 11:52 PM
Graduate student Mary Clare Beytagh ended the Spotlight session, presenting on a new hiPSC-marked model of group 3 medullablastoma. She is using the system to identify drivers of leptomeningeal metastasis.
#KSMetastasis25
#KSMetastasis25
Jonathan Rennhack presented on how CCL2 regulates metastasis in colorectal cancer by changing transcription factor dynamics in the cancer cells.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 11:42 PM
Jonathan Rennhack presented on how CCL2 regulates metastasis in colorectal cancer by changing transcription factor dynamics in the cancer cells.
#KSMetastasis25
#KSMetastasis25
Postdoc Anna Adam Artigues presented very intruding data showing that peripheral sympathetic Nerve damage stimulate the metastatic outgrowth of cancer cells that have disseminated to the brain.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 11:32 PM
Postdoc Anna Adam Artigues presented very intruding data showing that peripheral sympathetic Nerve damage stimulate the metastatic outgrowth of cancer cells that have disseminated to the brain.
#KSMetastasis25
#KSMetastasis25
Second Spotlight speaker - Rebecca Dodd - spoke on Epigenetic Plasticity driving Metastasis of sarcoma through PRC2-Dependent Stromal Remodeling and, in particular, IL-17D Signaling.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 11:24 PM
Second Spotlight speaker - Rebecca Dodd - spoke on Epigenetic Plasticity driving Metastasis of sarcoma through PRC2-Dependent Stromal Remodeling and, in particular, IL-17D Signaling.
#KSMetastasis25
#KSMetastasis25
In our second spot light session of late-breaking abstracts, we first heard from Yunfan Sun who using Spatial Multi Omics, at multiple time point, to define how changes in the TME drive metastatic colonization.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 11:17 PM
In our second spot light session of late-breaking abstracts, we first heard from Yunfan Sun who using Spatial Multi Omics, at multiple time point, to define how changes in the TME drive metastatic colonization.
#KSMetastasis25
#KSMetastasis25
Maria S Sosa presented on how late disseminated cells can facilitate the re-awakening of dormant, early disseminated tumor cells through direct interactions and by modulating the microenvironment.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 11:10 PM
Maria S Sosa presented on how late disseminated cells can facilitate the re-awakening of dormant, early disseminated tumor cells through direct interactions and by modulating the microenvironment.
#KSMetastasis25
#KSMetastasis25
Myriam Labelle presented new work on how Zinc Finger and BTB Domain Containing 18 (ZBTB18) regulates Tumor Cell-Immune Cell Crosstalk to control Metastasis.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 10:45 PM
Myriam Labelle presented new work on how Zinc Finger and BTB Domain Containing 18 (ZBTB18) regulates Tumor Cell-Immune Cell Crosstalk to control Metastasis.
#KSMetastasis25
#KSMetastasis25
Jean-Christophe Marine presented elegant work on niches (perivascular - hypoxic - invading front) in primary tumors that endow cancer cells with the ability to metastasis.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 10:37 PM
Jean-Christophe Marine presented elegant work on niches (perivascular - hypoxic - invading front) in primary tumors that endow cancer cells with the ability to metastasis.
#KSMetastasis25
#KSMetastasis25
Samra Turajlic presented extensive work deconvoluting the clonal evolution of metastasis. Chromosomal instability is a key driver - and a necrotic microenvironment helps. Inspiring use of patient samples to understand key biology - with clinical trials in the works.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 5:05 PM
Samra Turajlic presented extensive work deconvoluting the clonal evolution of metastasis. Chromosomal instability is a key driver - and a necrotic microenvironment helps. Inspiring use of patient samples to understand key biology - with clinical trials in the works.
#KSMetastasis25
#KSMetastasis25
Unfortunately, Gelareh Zadeh could not attend in person, and we missed her - but after Covid, we all know how to interact by zoom: Great remote presentation on her important work on Methylation and Proteomic Signatures of Lung Cancer as Predictive Biomarkers of Brain Metastasis.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 3:44 PM
Unfortunately, Gelareh Zadeh could not attend in person, and we missed her - but after Covid, we all know how to interact by zoom: Great remote presentation on her important work on Methylation and Proteomic Signatures of Lung Cancer as Predictive Biomarkers of Brain Metastasis.
#KSMetastasis25
#KSMetastasis25
Ending the Joint sessions between #KSMetastasis25 and #KSNeuroCancer25, Kylynda Bauer presented on the effects of the gut microbiome on liver cancer - via neuroimmune crosstalk.
January 21, 2025 at 3:18 PM
Ending the Joint sessions between #KSMetastasis25 and #KSNeuroCancer25, Kylynda Bauer presented on the effects of the gut microbiome on liver cancer - via neuroimmune crosstalk.
Postdoc Golnaz Morad gave a thought provoking talk linking oral microbiota to brain metastasis and raising the question about whether gum disease could be a risk factor. Will be exciting to follow her work.
KSMetastasis25
KSMetastasis25
January 21, 2025 at 3:12 PM
Postdoc Golnaz Morad gave a thought provoking talk linking oral microbiota to brain metastasis and raising the question about whether gum disease could be a risk factor. Will be exciting to follow her work.
KSMetastasis25
KSMetastasis25
Erica Sloan discussed how some cancer treatments - doxorubicin and radiation - stimulate sympathetic signaling to promote metastasis; explaining why women also treated with beta-blockers for high-blood pressure have much lower odds of metastatic relapse.
KSMetastasis25
KSMetastasis25
January 21, 2025 at 1:52 AM
Erica Sloan discussed how some cancer treatments - doxorubicin and radiation - stimulate sympathetic signaling to promote metastasis; explaining why women also treated with beta-blockers for high-blood pressure have much lower odds of metastatic relapse.
KSMetastasis25
KSMetastasis25
Graduate student Morgan Fox gave a very nice talk on how the non-canonical activation of FGFR1 drives brain metastasis of ER+ breast cancer in aged mice (or “non-young” as Devon Lawson diplomatically put it for those of us over 40!)
KSMetastasis25
KSMetastasis25
January 21, 2025 at 1:30 AM
Graduate student Morgan Fox gave a very nice talk on how the non-canonical activation of FGFR1 drives brain metastasis of ER+ breast cancer in aged mice (or “non-young” as Devon Lawson diplomatically put it for those of us over 40!)
KSMetastasis25
KSMetastasis25
Exciting presentation by co-organizer Manuel Valiente: through heroic efforts, his lab has established models to study the major clinical problems of local relapse of surgical excised brain metastasis and neurocognitive effects of brain masses.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 1:06 AM
Exciting presentation by co-organizer Manuel Valiente: through heroic efforts, his lab has established models to study the major clinical problems of local relapse of surgical excised brain metastasis and neurocognitive effects of brain masses.
#KSMetastasis25
#KSMetastasis25
Postdoc Alexandra Newman from Kathryn Moore’s lab at NYU gave a thought provoking talk on how myocardial infection - by affecting myeloid cells - can drive metastasis.
#KSMetastasis25
#KSMetastasis25
January 21, 2025 at 12:39 AM
Postdoc Alexandra Newman from Kathryn Moore’s lab at NYU gave a thought provoking talk on how myocardial infection - by affecting myeloid cells - can drive metastasis.
#KSMetastasis25
#KSMetastasis25
@venkatesh-lab.bsky.social presented data on neuronal activity affecting small cell lung cancer initiation/growth and establishment in the brain (preprint: www.biorxiv.org/content/10.1...)
January 21, 2025 at 12:33 AM
@venkatesh-lab.bsky.social presented data on neuronal activity affecting small cell lung cancer initiation/growth and establishment in the brain (preprint: www.biorxiv.org/content/10.1...)
Sergei Grivennikov presented on microbiota-induced interleukins and how they influence hepatocytes and immune cells to promote colon cancer metastasis (- and NETs made a very brief appearance).
KSMetastasis25
KSMetastasis25
January 21, 2025 at 12:08 AM
Sergei Grivennikov presented on microbiota-induced interleukins and how they influence hepatocytes and immune cells to promote colon cancer metastasis (- and NETs made a very brief appearance).
KSMetastasis25
KSMetastasis25
The pioneer in thinking about cancer a systemic disease - David Lyden - showed us how extracellular vesicles can drive not just metastasis but also altered lipid metabolism in the liver and clotting in cancer.
#KSMetastasis25
#KSMetastasis25
January 20, 2025 at 4:12 PM
The pioneer in thinking about cancer a systemic disease - David Lyden - showed us how extracellular vesicles can drive not just metastasis but also altered lipid metabolism in the liver and clotting in cancer.
#KSMetastasis25
#KSMetastasis25