McColl lab
@mccoll-lab-uoe.bsky.social
Neuroimmunology lab
- University of Edinburgh
- UK Dementia Research Institute
https://discovery-brain-sciences.ed.ac.uk/our-staff/research-groups/dr-barry-mccoll
https://www.ukdri.ac.uk/team/barry-mccoll
- University of Edinburgh
- UK Dementia Research Institute
https://discovery-brain-sciences.ed.ac.uk/our-staff/research-groups/dr-barry-mccoll
https://www.ukdri.ac.uk/team/barry-mccoll
Pinned
McColl lab
@mccoll-lab-uoe.bsky.social
· Jan 13
Acute ischaemic stroke alters the composition and function of circulating B cells
Distinct B cell populations are found in circulation, including those with innate-like properties, that have varied functions in pathogen protection, …
www.sciencedirect.com
Delighted our new paper is out describing how stroke alters systemic B cell properties, relevant to recovery & complications after stroke eg infection, cognitive decline. Pleasure to work with our collaborators & thanks to our funders for supporting www.sciencedirect.com/science/arti...
Great work coming out from the @dr-l-mcculloch.bsky.social lab @edinuni-irr.bsky.social
Two new papers from the McCulloch lab reveal how the body changes after experiencing a stroke.
1. Stroke and “fight-or-flight” response weakens the immune system > edin.ac/4a166dD
2. Long term changes to the intestinal microbiome seen after stroke > edin.ac/4jR2LBl
1. Stroke and “fight-or-flight” response weakens the immune system > edin.ac/4a166dD
2. Long term changes to the intestinal microbiome seen after stroke > edin.ac/4jR2LBl
January 20, 2026 at 10:55 AM
Great work coming out from the @dr-l-mcculloch.bsky.social lab @edinuni-irr.bsky.social
Reposted by McColl lab
Dr Julija Krupic and researchers from the UK DRI at UCL, the University of Cambridge and the Sainsbury Wellcome Centre at UCL, have developed and validated a fully automated Novel Object Recognition (NOR) test that runs entirely in a mouse’s home cage.
www.sainsburywellcome.org/web/blog/hom...
www.sainsburywellcome.org/web/blog/hom...
Home sweet home: Automating novel object recognition | Sainsbury Wellcome Centre
www.sainsburywellcome.org
January 16, 2026 at 5:45 PM
Dr Julija Krupic and researchers from the UK DRI at UCL, the University of Cambridge and the Sainsbury Wellcome Centre at UCL, have developed and validated a fully automated Novel Object Recognition (NOR) test that runs entirely in a mouse’s home cage.
www.sainsburywellcome.org/web/blog/hom...
www.sainsburywellcome.org/web/blog/hom...
Great team-work behind our paper just published on stroke-induced immune cell changes, involving groups across @edinunineuro.bsky.social
@edinuni-irr.bsky.social
@ukdri.ac.uk
@lydiabeckeriii.bsky.social.
A pandemic in midst of study not anticipated at outset!
@edinuni-irr.bsky.social
@ukdri.ac.uk
@lydiabeckeriii.bsky.social.
A pandemic in midst of study not anticipated at outset!
I’m excited to start 2026 with our new collaborative research paper examining circulating B cell populations in acute ischemic stroke patients, which is particularly exciting as we see translation of our previous data from animal models into patients. www.sciencedirect.com/science/arti...
Acute ischaemic stroke alters the composition and function of circulating B cells
Distinct B cell populations are found in circulation, including those with innate-like properties, that have varied functions in pathogen protection, …
www.sciencedirect.com
January 14, 2026 at 3:49 PM
Great team-work behind our paper just published on stroke-induced immune cell changes, involving groups across @edinunineuro.bsky.social
@edinuni-irr.bsky.social
@ukdri.ac.uk
@lydiabeckeriii.bsky.social.
A pandemic in midst of study not anticipated at outset!
@edinuni-irr.bsky.social
@ukdri.ac.uk
@lydiabeckeriii.bsky.social.
A pandemic in midst of study not anticipated at outset!
Delighted our new paper is out describing how stroke alters systemic B cell properties, relevant to recovery & complications after stroke eg infection, cognitive decline. Pleasure to work with our collaborators & thanks to our funders for supporting www.sciencedirect.com/science/arti...
Acute ischaemic stroke alters the composition and function of circulating B cells
Distinct B cell populations are found in circulation, including those with innate-like properties, that have varied functions in pathogen protection, …
www.sciencedirect.com
January 13, 2026 at 10:04 AM
Delighted our new paper is out describing how stroke alters systemic B cell properties, relevant to recovery & complications after stroke eg infection, cognitive decline. Pleasure to work with our collaborators & thanks to our funders for supporting www.sciencedirect.com/science/arti...
We have an exciting PhD project open for applications - fully-funded. Apply here: www.findaphd.com/phds/project...
Precision Medicine DTP - Towards precision therapeutics for macrophages: developing a multi-organ understanding of macrophage control by TGF-β at University of Edinburgh on FindAPhD.com
PhD Project - Precision Medicine DTP - Towards precision therapeutics for macrophages: developing a multi-organ understanding of macrophage control by TGF-β at University of Edinburgh, listed on ...
www.findaphd.com
November 19, 2025 at 5:17 PM
We have an exciting PhD project open for applications - fully-funded. Apply here: www.findaphd.com/phds/project...
Reposted by McColl lab
Huge congratulations to UK DRI Founding Director Prof Bart De Strooper who has been awarded an Honorary CBE for his contributions to dementia research! 👏
Read more👉 buff.ly/xhKD5Aj
Read more👉 buff.ly/xhKD5Aj
October 20, 2025 at 5:00 PM
Huge congratulations to UK DRI Founding Director Prof Bart De Strooper who has been awarded an Honorary CBE for his contributions to dementia research! 👏
Read more👉 buff.ly/xhKD5Aj
Read more👉 buff.ly/xhKD5Aj
Reposted by McColl lab
🎉 This week, we’re proud to officially launch the BHF-UK DRI Centre for Vascular Dementia Research, in partnership with the British Heart Foundation.
The centre will explore how changes in vascular health contribute to dementia - paving the way for new treatments👉 buff.ly/5ZEjQx8
The centre will explore how changes in vascular health contribute to dementia - paving the way for new treatments👉 buff.ly/5ZEjQx8
October 13, 2025 at 8:30 AM
🎉 This week, we’re proud to officially launch the BHF-UK DRI Centre for Vascular Dementia Research, in partnership with the British Heart Foundation.
The centre will explore how changes in vascular health contribute to dementia - paving the way for new treatments👉 buff.ly/5ZEjQx8
The centre will explore how changes in vascular health contribute to dementia - paving the way for new treatments👉 buff.ly/5ZEjQx8
Very pleased to see this published! Team effort from several labs @edinunineuro.bsky.social and Carpanini lab @cardiffunilib.bsky.social @ukdri.ac.uk - bit more support for microglia resilience involving TREM2 in chronic brain disease. www.frontiersin.org/journals/neu...
Frontiers | TREM2 supports neuronal protection and microglial reactivity without an effect on misfolded protein deposition in chronic neurodegenerative prion disease
IntroductionTriggering receptor expressed on myeloid cells-2 (TREM2) variants have been identified as risk factors for neurodegenerative disease, including A...
www.frontiersin.org
May 7, 2025 at 8:47 PM
Very pleased to see this published! Team effort from several labs @edinunineuro.bsky.social and Carpanini lab @cardiffunilib.bsky.social @ukdri.ac.uk - bit more support for microglia resilience involving TREM2 in chronic brain disease. www.frontiersin.org/journals/neu...
Reposted by McColl lab
Abstract Submission Open!!
As we slide into the weekend, it's the ideal time to think about your abstract for #EMDS2025. Lots of opportunities for #ECRs to present...and prizes up for grabs!
👉 www.emds2025.com
@britsocimm.bsky.social @cytokinesociety.bsky.social @societymucosalimm.bsky.social
As we slide into the weekend, it's the ideal time to think about your abstract for #EMDS2025. Lots of opportunities for #ECRs to present...and prizes up for grabs!
👉 www.emds2025.com
@britsocimm.bsky.social @cytokinesociety.bsky.social @societymucosalimm.bsky.social
March 21, 2025 at 11:50 AM
Abstract Submission Open!!
As we slide into the weekend, it's the ideal time to think about your abstract for #EMDS2025. Lots of opportunities for #ECRs to present...and prizes up for grabs!
👉 www.emds2025.com
@britsocimm.bsky.social @cytokinesociety.bsky.social @societymucosalimm.bsky.social
As we slide into the weekend, it's the ideal time to think about your abstract for #EMDS2025. Lots of opportunities for #ECRs to present...and prizes up for grabs!
👉 www.emds2025.com
@britsocimm.bsky.social @cytokinesociety.bsky.social @societymucosalimm.bsky.social
Reposted by McColl lab
Research into rare conditions is vital to enhance care for people affected and open up new treatment options. In doing so, it also sheds light on the underlying mechanisms applicable to other more common conditions.
Find out more about the Hunt Lab⬇️ buff.ly/3QzKAlI
Find out more about the Hunt Lab⬇️ buff.ly/3QzKAlI
February 28, 2025 at 9:30 AM
Research into rare conditions is vital to enhance care for people affected and open up new treatment options. In doing so, it also sheds light on the underlying mechanisms applicable to other more common conditions.
Find out more about the Hunt Lab⬇️ buff.ly/3QzKAlI
Find out more about the Hunt Lab⬇️ buff.ly/3QzKAlI
Reposted by McColl lab
It's #RareDiseaseDay! Rare diseases are individually rare but collectively common, affecting 3.5 million people in the UK. Bring out your stripey socks to raise awareness #RareDisease #ShowYourStripes @medicsforrare.bsky.social
Find out more about RareDisease at www.m4rd.org www.rarediseaseday.org
Find out more about RareDisease at www.m4rd.org www.rarediseaseday.org
February 28, 2025 at 8:45 AM
It's #RareDiseaseDay! Rare diseases are individually rare but collectively common, affecting 3.5 million people in the UK. Bring out your stripey socks to raise awareness #RareDisease #ShowYourStripes @medicsforrare.bsky.social
Find out more about RareDisease at www.m4rd.org www.rarediseaseday.org
Find out more about RareDisease at www.m4rd.org www.rarediseaseday.org