Mathieu Lupien
@matlupien.bsky.social
Senior scientist @Princess Margaret Cancer Centre, Prof @UofT. BHAG: conquer cancer by treating it as a disease of the chromatin.
Reposted by Mathieu Lupien
One of our top-rated posts on @altmetric.com this past was published in @nataging.nature.com. You can read 'Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries' here: spklr.io/63325BMpTZ
Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries - Nature Aging
In cross-sectional and longitudinal analyses of 86,149 participants across 27 European countries, Amoruso, Hernandez and colleagues identify multilingualism as a protective factor against accelerated aging, using biobehavioral age gaps.
spklr.io
November 14, 2025 at 8:07 PM
One of our top-rated posts on @altmetric.com this past was published in @nataging.nature.com. You can read 'Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries' here: spklr.io/63325BMpTZ
Lest We Forget
N'oublions Jamais
N'oublions Jamais
November 11, 2025 at 3:59 PM
Lest We Forget
N'oublions Jamais
N'oublions Jamais
DNA replication is only half the story. Cells actually replicate their chromatin, ensuring that both the DNA sequences and the chromatin states are faithfully maintained to preserve cell identity and function after division. Here's a glimpse of how this process unfolds, courtesy of theCrux:
Epigenetic Replication during DNA Replication - Replicating histones and DNA methylation
YouTube video by theCrux
www.youtube.com
November 11, 2025 at 3:08 PM
DNA replication is only half the story. Cells actually replicate their chromatin, ensuring that both the DNA sequences and the chromatin states are faithfully maintained to preserve cell identity and function after division. Here's a glimpse of how this process unfolds, courtesy of theCrux:
Reposted by Mathieu Lupien
Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...
SCIENTIST – Developmental, Stem Cell & Cancer Biology Program - Toronto (City), Ontario (CA) job with The Hospital for Sick Children - Developmental & Stem Cell Biology Program | 12848200
Discovery-based and/or translational research using model organism genetics and/or stem cell and organoid platforms to study paediatric cancer.
www.nature.com
October 28, 2025 at 10:06 PM
Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...
Reposted by Mathieu Lupien
We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.
October 14, 2025 at 8:21 PM
We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.
Reposted by Mathieu Lupien
Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team!
Please repost!
jobs.jic.ac.uk/Details.asp?...
Please repost!
jobs.jic.ac.uk/Details.asp?...
John Innes Centre
jobs.jic.ac.uk
October 8, 2025 at 9:04 AM
Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team!
Please repost!
jobs.jic.ac.uk/Details.asp?...
Please repost!
jobs.jic.ac.uk/Details.asp?...
Reposted by Mathieu Lupien
❓Can a father’s environmental exposures before conception influence their offspring?
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal
imageimagePaternal environmental exposures have been linked with modulation of phenotype and
disease risk in offspring via largely unclear mechanisms. This study employs in vitro
fertilization and sin...
www.embopress.org
September 27, 2025 at 7:28 AM
❓Can a father’s environmental exposures before conception influence their offspring?
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
Reposted by Mathieu Lupien
Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!
Full Professorship in Molecular Mechanisms of Disease
The Max Perutz Labs - one of Europe’s leading institutes for basic research in the life sciences - invite applications for a Full Professorship in Molecular Mechanisms of Disease. We are seeking outst...
www.maxperutzlabs.ac.at
September 4, 2025 at 10:25 AM
Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!
Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...
Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins - Nature Communications
Epigenome editing programs gene silencing without inducing DNA breaks but challenges in delivery into human cells limit its broader use. Here, the authors present the RENDER platform, which uses virus...
www.nature.com
August 29, 2025 at 7:27 PM
Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...
Reposted by Mathieu Lupien
Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....
August 7, 2025 at 4:20 PM
Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....
Reposted by Mathieu Lupien
This acquisition will bring together two pioneering companies with a shared vision: to make single cell analysis more powerful, affordable and accessible to researchers worldwide.
Learn more: bit.ly/4mAWAS8
Learn more: bit.ly/4mAWAS8
August 7, 2025 at 8:14 PM
This acquisition will bring together two pioneering companies with a shared vision: to make single cell analysis more powerful, affordable and accessible to researchers worldwide.
Learn more: bit.ly/4mAWAS8
Learn more: bit.ly/4mAWAS8
One often hears that DNA is the blueprint of life. Today, I read a really nice paper that begins with "proteins are the cornerstone of life". By that logic, I might start referring to RNA as the scaffold, and chromatin as the framework that shapes it all.
Regardless, the paper is a must-read:
Regardless, the paper is a must-read:
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures
Proteins are the cornerstone of life. However, the proteomic blueprint of aging across human tissues remains uncharted. Here, we present a comprehensi…
www.sciencedirect.com
July 31, 2025 at 7:19 PM
One often hears that DNA is the blueprint of life. Today, I read a really nice paper that begins with "proteins are the cornerstone of life". By that logic, I might start referring to RNA as the scaffold, and chromatin as the framework that shapes it all.
Regardless, the paper is a must-read:
Regardless, the paper is a must-read:
Reposted by Mathieu Lupien
Congratulations to this new generation of leading cancer scientists, and to the message they’re sending, with 50% of the awardees placing epigenetics at the heart of their research. The future is speaking. The path forward is both bright and bold.
July 30, 2025 at 4:18 AM
Congratulations to this new generation of leading cancer scientists, and to the message they’re sending, with 50% of the awardees placing epigenetics at the heart of their research. The future is speaking. The path forward is both bright and bold.
Nice study showing how DNA mutagenesis can be driven by transcription factor (TF) competition with mismatch repair machinery: www.cell.com/cell/fulltex...
Worth considering alongside the uneven mutagenesis of TF cistromes tied to their cancer-type-specific essentiality: www.cell.com/cancer-cell/...
Worth considering alongside the uneven mutagenesis of TF cistromes tied to their cancer-type-specific essentiality: www.cell.com/cancer-cell/...
DNA mutagenesis driven by transcription factor competition with mismatch repair
Competition between transcription factors and mismatch repair machinery drives localized
hypermutation at regulatory elements, with implications for cancer and genome evolution.
www.cell.com
July 30, 2025 at 2:15 PM
Nice study showing how DNA mutagenesis can be driven by transcription factor (TF) competition with mismatch repair machinery: www.cell.com/cell/fulltex...
Worth considering alongside the uneven mutagenesis of TF cistromes tied to their cancer-type-specific essentiality: www.cell.com/cancer-cell/...
Worth considering alongside the uneven mutagenesis of TF cistromes tied to their cancer-type-specific essentiality: www.cell.com/cancer-cell/...
Reposted by Mathieu Lupien
Great opportunity to join the vibrant developmental biology in Toronto (and boss around me and @wbderry.bsky.social).
jobs.sciencecareers.org/job/673968/p...
jobs.sciencecareers.org/job/673968/p...
Program Head – Developmental, Stem Cell, and Cancer Biology - Toronto (Region), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 673968
Provide leadership and mentorship to members of the Developmental, Stem Cell & Cancer and influence the scientific direction of the Research Institute
jobs.sciencecareers.org
July 27, 2025 at 11:35 PM
Great opportunity to join the vibrant developmental biology in Toronto (and boss around me and @wbderry.bsky.social).
jobs.sciencecareers.org/job/673968/p...
jobs.sciencecareers.org/job/673968/p...
Reposted by Mathieu Lupien
A jewel of a presentation on the history of chromatin. Always a pleasure to go back in time with those who helped shape it. I am grateful for the insights and stories shared by Drs. Ada and Donald Olins. youtu.be/QExPH1bVbGU
The History and Mystery of Chromatin
YouTube video by University of New England
youtu.be
July 23, 2025 at 7:04 PM
A jewel of a presentation on the history of chromatin. Always a pleasure to go back in time with those who helped shape it. I am grateful for the insights and stories shared by Drs. Ada and Donald Olins. youtu.be/QExPH1bVbGU
A jewel of a presentation on the history of chromatin. Always a pleasure to go back in time with those who helped shape it. I am grateful for the insights and stories shared by Drs. Ada and Donald Olins. youtu.be/QExPH1bVbGU
The History and Mystery of Chromatin
YouTube video by University of New England
youtu.be
July 23, 2025 at 7:04 PM
A jewel of a presentation on the history of chromatin. Always a pleasure to go back in time with those who helped shape it. I am grateful for the insights and stories shared by Drs. Ada and Donald Olins. youtu.be/QExPH1bVbGU
Less than a month to go until the GRC on Hormone-Dependent Cancers! Looking forward to reconnecting with the community and sharing our latest on epigenomics of ecDNAs in tumor evolution. www.grc.org/hormone-depe...
2025 Hormone-Dependent Cancers Conference GRC
The 2025 Gordon Research Conference on Hormone-Dependent Cancers will be held in Newry, Maine. Apply today to reserve your spot.
www.grc.org
July 21, 2025 at 3:46 AM
Less than a month to go until the GRC on Hormone-Dependent Cancers! Looking forward to reconnecting with the community and sharing our latest on epigenomics of ecDNAs in tumor evolution. www.grc.org/hormone-depe...
Reposted by Mathieu Lupien
Are you currently in the ERE related field & want to find new collaborative opportunities? Join our Chairs @chiappinellilab.bsky.social, @shenhui1986.bsky.social, Ting & Tao at #EREHD25 this Nov!
🎙️Talk Submission extended to 03 Sept
💰Final few $500 grants remaining
Don't Miss out! bit.ly/4eRq9Mp
🎙️Talk Submission extended to 03 Sept
💰Final few $500 grants remaining
Don't Miss out! bit.ly/4eRq9Mp
July 17, 2025 at 3:23 PM
Are you currently in the ERE related field & want to find new collaborative opportunities? Join our Chairs @chiappinellilab.bsky.social, @shenhui1986.bsky.social, Ting & Tao at #EREHD25 this Nov!
🎙️Talk Submission extended to 03 Sept
💰Final few $500 grants remaining
Don't Miss out! bit.ly/4eRq9Mp
🎙️Talk Submission extended to 03 Sept
💰Final few $500 grants remaining
Don't Miss out! bit.ly/4eRq9Mp
If you're into super-resolution microscopy, check out the new story from Myles Brown's lab showing how chromatin architecture responds to hormone signaling at enhancers. Dynamic, ligand-dependent changes in H3K27ac structure with implications for endocrine resistance. www.biorxiv.org/content/10.1...
Super-resolution microscopy reveals distinct epigenetic states regulated by estrogen receptor activity
Changes in gene expression regulated by ligand-dependent transcription factors such as estrogen receptor-α (ERα) involves the recruitment of coactivators including p300 that acetylates histone H3 at l...
www.biorxiv.org
July 16, 2025 at 12:50 PM
If you're into super-resolution microscopy, check out the new story from Myles Brown's lab showing how chromatin architecture responds to hormone signaling at enhancers. Dynamic, ligand-dependent changes in H3K27ac structure with implications for endocrine resistance. www.biorxiv.org/content/10.1...
Reposted by Mathieu Lupien
Come join us in Vancouver! Exciting opportunity for a more senior investigator researching new regenerative medicine approaches for Type 1 diabetes. $8M in funding for successful candidate research.ubc.ca/media/file/j...
research.ubc.ca
July 7, 2025 at 8:07 PM
Come join us in Vancouver! Exciting opportunity for a more senior investigator researching new regenerative medicine approaches for Type 1 diabetes. $8M in funding for successful candidate research.ubc.ca/media/file/j...
Reposted by Mathieu Lupien
📣 We’re recruiting 1-2 Group Leaders! NCMBM is looking for early-career researchers ready to establish their independent research groups!
🧬 With an attractive start-up package, help us shape the future of molecular biosciences and medicine in 🇳🇴 and be part of the @nordicembl.bsky.social!
🧬 With an attractive start-up package, help us shape the future of molecular biosciences and medicine in 🇳🇴 and be part of the @nordicembl.bsky.social!
June 30, 2025 at 7:09 AM
📣 We’re recruiting 1-2 Group Leaders! NCMBM is looking for early-career researchers ready to establish their independent research groups!
🧬 With an attractive start-up package, help us shape the future of molecular biosciences and medicine in 🇳🇴 and be part of the @nordicembl.bsky.social!
🧬 With an attractive start-up package, help us shape the future of molecular biosciences and medicine in 🇳🇴 and be part of the @nordicembl.bsky.social!
Reposted by Mathieu Lupien
The July issue of Cancer Discovery is now online! The cover features work by Alexandra Redding, Elda Grabocka, and colleagues on intercellular heterogeneity of stress granules and chemotherapy response - read that and much more here: aacrjournals.org/cancerdiscov...
July 3, 2025 at 5:05 PM
The July issue of Cancer Discovery is now online! The cover features work by Alexandra Redding, Elda Grabocka, and colleagues on intercellular heterogeneity of stress granules and chemotherapy response - read that and much more here: aacrjournals.org/cancerdiscov...
Reposted by Mathieu Lupien
come join us in our brand new research building!
www.crc.ulaval.ca/wp-content/u...
www.crc.ulaval.ca/wp-content/u...
July 4, 2025 at 7:20 PM
come join us in our brand new research building!
www.crc.ulaval.ca/wp-content/u...
www.crc.ulaval.ca/wp-content/u...
Reposted by Mathieu Lupien
Please RT! The oncology department & McGill is hiring an Assistant professor for a lab to be located at Lady Davis Institute (where I am!). McGill and the Lady Davis are fantastic places to do research and Montreal is great city to live in.
mcgill.wd3.myworkdayjobs.com/en-US/McGill...
mcgill.wd3.myworkdayjobs.com/en-US/McGill...
Assistant Professor (Research), Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research (C1-250514)
Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...
mcgill.wd3.myworkdayjobs.com
July 1, 2025 at 5:14 PM
Please RT! The oncology department & McGill is hiring an Assistant professor for a lab to be located at Lady Davis Institute (where I am!). McGill and the Lady Davis are fantastic places to do research and Montreal is great city to live in.
mcgill.wd3.myworkdayjobs.com/en-US/McGill...
mcgill.wd3.myworkdayjobs.com/en-US/McGill...