@martin-matl.bsky.social
Reposted
The demystification of piRNA clusters
if you wonder how cells generate piRNAs specifically against transposons & you are looking for a weekend read
check out @86dominik.bsky.social's opus magna (or Dominik's great thread)
a shared project with the one and only Rippei Hayashi, lab alumnus & friend
if you wonder how cells generate piRNAs specifically against transposons & you are looking for a weekend read
check out @86dominik.bsky.social's opus magna (or Dominik's great thread)
a shared project with the one and only Rippei Hayashi, lab alumnus & friend
How does the piRNA pathway solve the self vs. non-self problem? 🧬
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements https://www.biorxiv.org/content/10.64898/2026.02.07.704324v1
February 13, 2026 at 8:39 PM
The demystification of piRNA clusters
if you wonder how cells generate piRNAs specifically against transposons & you are looking for a weekend read
check out @86dominik.bsky.social's opus magna (or Dominik's great thread)
a shared project with the one and only Rippei Hayashi, lab alumnus & friend
if you wonder how cells generate piRNAs specifically against transposons & you are looking for a weekend read
check out @86dominik.bsky.social's opus magna (or Dominik's great thread)
a shared project with the one and only Rippei Hayashi, lab alumnus & friend
Reposted
How does the piRNA pathway solve the self vs. non-self problem? 🧬
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements https://www.biorxiv.org/content/10.64898/2026.02.07.704324v1
February 13, 2026 at 3:11 PM
How does the piRNA pathway solve the self vs. non-self problem? 🧬
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
Soon-to-be landmark paper on how the piRNA pathway achieves specificity against transposon sequences by @86dominik.bsky.social , @rippei.bsky.social and others is now out as a preprint on bioRxiv!
A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements https://www.biorxiv.org/content/10.64898/2026.02.07.704324v1
February 10, 2026 at 8:36 AM
Soon-to-be landmark paper on how the piRNA pathway achieves specificity against transposon sequences by @86dominik.bsky.social , @rippei.bsky.social and others is now out as a preprint on bioRxiv!
Reposted
@lorenzoorts.bsky.social previously worked as a postdoctoral fellow at @impvienna.bsky.social in Austria. She will establish a new lab at IMB to investigate how mRNA translation is activated in the early embryo. Welcome to IMB Laura! 💐
Read more here: www.imb.de/about-imb/ne...
Read more here: www.imb.de/about-imb/ne...
February 6, 2026 at 2:27 PM
@lorenzoorts.bsky.social previously worked as a postdoctoral fellow at @impvienna.bsky.social in Austria. She will establish a new lab at IMB to investigate how mRNA translation is activated in the early embryo. Welcome to IMB Laura! 💐
Read more here: www.imb.de/about-imb/ne...
Read more here: www.imb.de/about-imb/ne...
Reposted
Ulrich’s research will help advance our understanding of RNA biology & gene regulation, as well as how these mechanisms might be altered during viral infections & other diseases.
@hohmannulrich.bsky.social comes from the @impvienna.bsky.social / @imbavienna.bsky.social
www.imb.de/about-imb/ne...
@hohmannulrich.bsky.social comes from the @impvienna.bsky.social / @imbavienna.bsky.social
www.imb.de/about-imb/ne...
February 9, 2026 at 11:14 AM
Ulrich’s research will help advance our understanding of RNA biology & gene regulation, as well as how these mechanisms might be altered during viral infections & other diseases.
@hohmannulrich.bsky.social comes from the @impvienna.bsky.social / @imbavienna.bsky.social
www.imb.de/about-imb/ne...
@hohmannulrich.bsky.social comes from the @impvienna.bsky.social / @imbavienna.bsky.social
www.imb.de/about-imb/ne...
Reposted
Very happy to share my postdoc work (on preprint), where we try to understand a long-standing transcription-silencing paradox, and uncovered a hidden RNA decay arm of nuclear piRNA pathway, see detailed threads quoted from @juliusbrennecke.bsky.social
Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway.
And found a hidden RNA-decay axis from Piwi to the RNA exosome.
And found a hidden RNA-decay axis from Piwi to the RNA exosome.
RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing https://www.biorxiv.org/content/10.64898/2025.12.16.694471v1
December 22, 2025 at 7:38 PM
Very happy to share my postdoc work (on preprint), where we try to understand a long-standing transcription-silencing paradox, and uncovered a hidden RNA decay arm of nuclear piRNA pathway, see detailed threads quoted from @juliusbrennecke.bsky.social
Reposted
Our leaving gift and starter-pack for @hohmannulrich.bsky.social to open his new lab at @imbmainz.bsky.social! Ulrich has made many exciting contributions to RNA packaging. We will miss him and his dry humor, and can't wait to see what he will discover in his lab!
December 19, 2025 at 2:12 PM
Our leaving gift and starter-pack for @hohmannulrich.bsky.social to open his new lab at @imbmainz.bsky.social! Ulrich has made many exciting contributions to RNA packaging. We will miss him and his dry humor, and can't wait to see what he will discover in his lab!
Reposted
When transposons jump, genomes diverge - even in cultured cells.
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
October 14, 2025 at 8:34 PM
When transposons jump, genomes diverge - even in cultured cells.
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
Reposted
just in time for the opening of the @hohmannulrich.bsky.social group at @imbmainz.bsky.social
what started as a project on how cells export piRNA precursors, ended up as a tour de force in mRNA export. truly wonderful collaboration with @plaschkalab.bsky.social at the @viennabiocenter.bsky.social
what started as a project on how cells export piRNA precursors, ended up as a tour de force in mRNA export. truly wonderful collaboration with @plaschkalab.bsky.social at the @viennabiocenter.bsky.social
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
November 7, 2025 at 6:03 PM
just in time for the opening of the @hohmannulrich.bsky.social group at @imbmainz.bsky.social
what started as a project on how cells export piRNA precursors, ended up as a tour de force in mRNA export. truly wonderful collaboration with @plaschkalab.bsky.social at the @viennabiocenter.bsky.social
what started as a project on how cells export piRNA precursors, ended up as a tour de force in mRNA export. truly wonderful collaboration with @plaschkalab.bsky.social at the @viennabiocenter.bsky.social
Reposted
what you always wanted to know about the molecular choreography of nuclear mRNA packaging and export.
thought-provoking review by our colleagues (local or in the RNA community).
@plaschkalab.bsky.social
@rupertfaraway.bsky.social
@thezenklusen.bsky.social
www.annualreviews.org/content/jour...
thought-provoking review by our colleagues (local or in the RNA community).
@plaschkalab.bsky.social
@rupertfaraway.bsky.social
@thezenklusen.bsky.social
www.annualreviews.org/content/jour...
Mechanisms of Messenger RNA Packaging and Export
The packaging and export of messenger RNA (mRNA) are essential cellular pathways that bridge the nuclear and cytoplasmic phases of eukaryotic gene expression. During their nuclear maturation, mRNAs ar...
www.annualreviews.org
October 18, 2025 at 3:08 PM
what you always wanted to know about the molecular choreography of nuclear mRNA packaging and export.
thought-provoking review by our colleagues (local or in the RNA community).
@plaschkalab.bsky.social
@rupertfaraway.bsky.social
@thezenklusen.bsky.social
www.annualreviews.org/content/jour...
thought-provoking review by our colleagues (local or in the RNA community).
@plaschkalab.bsky.social
@rupertfaraway.bsky.social
@thezenklusen.bsky.social
www.annualreviews.org/content/jour...
Reposted
1/ How do animals develop immunity against a newly encountered transposable element from scratch? Our study reveals that the mobility of TEs is their Achilles heel, allowing hosts to develop a powerful small RNA-mediated silencing response.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 14, 2025 at 5:09 PM
1/ How do animals develop immunity against a newly encountered transposable element from scratch? Our study reveals that the mobility of TEs is their Achilles heel, allowing hosts to develop a powerful small RNA-mediated silencing response.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
Greta Thunberg among 171 Gaza flotilla activists deported by Israel; ceasefire negotiations due to begin in Egypt – Middle East crisis live
Greta Thunberg among 171 Gaza flotilla activists deported by Israel; ceasefire negotiations due to begin in Egypt – Middle East crisis live
Activists deported to Greece and Slovakia; negotiators from the US, Israel and Hamas are set to begin talks
www.theguardian.com
October 6, 2025 at 12:26 PM
Greta Thunberg among 171 Gaza flotilla activists deported by Israel; ceasefire negotiations due to begin in Egypt – Middle East crisis live
Reposted
Congratulations to @vdeneke.bsky.social & Andreas Blaha @impvienna.bsky.social for their research on vertebrate fertilization, which was awarded this year's ÖGMBT Life Science Research Award in Austria for basic research!
🎉Congrats to our @vdeneke.bsky.social, postdoc in the @pauligroup.bsky.social, who has received the 2025 Life Sciences Research Award Austria from the ÖGMBT!
She's recognised for her groundbreaking work on the molecular mechanisms of fertilisation: www.imp.ac.at/news/article...
She's recognised for her groundbreaking work on the molecular mechanisms of fertilisation: www.imp.ac.at/news/article...
October 5, 2025 at 8:46 PM
Congratulations to @vdeneke.bsky.social & Andreas Blaha @impvienna.bsky.social for their research on vertebrate fertilization, which was awarded this year's ÖGMBT Life Science Research Award in Austria for basic research!
A well deserved award for @mjkellner.bsky.social on his awesome PhD work! Max is one of the most inspiring scientists I've been privilleged to meet. Happy to see his PhD work recognized by the ÖGMBT!
🎉 Congratulations to Max Kellner, former PhD student in the Penninger Lab, who was presented with the ÖGBMT Life Sciences PhD Award Austria. The award recognizes Kellner’s PhD research on how dangerous viruses emerge from natural reservoirs like bats. More: https://imba.science/3KiRYSN
October 1, 2025 at 8:08 AM
A well deserved award for @mjkellner.bsky.social on his awesome PhD work! Max is one of the most inspiring scientists I've been privilleged to meet. Happy to see his PhD work recognized by the ÖGMBT!
Reposted
Paris-Berlin sleeper: low carbon, 2 years old, constantly full, but currently losing SNCF a few million EUR/yr
Intl Jet fuel tax exemptions are 80 years old and cost the EU 22 million EUR/yr for the Paris-Berlin route alone.
And you're cutting... the sleeper?
www.theguardian.com/travel/2025/...
Intl Jet fuel tax exemptions are 80 years old and cost the EU 22 million EUR/yr for the Paris-Berlin route alone.
And you're cutting... the sleeper?
www.theguardian.com/travel/2025/...
It’s goodnight Vienna as Paris sleeper train to Austria and Berlin hit by cuts
Some Nightjet services suspended from mid-December after French withdrawal amid public budget crisis
www.theguardian.com
September 29, 2025 at 9:31 PM
Paris-Berlin sleeper: low carbon, 2 years old, constantly full, but currently losing SNCF a few million EUR/yr
Intl Jet fuel tax exemptions are 80 years old and cost the EU 22 million EUR/yr for the Paris-Berlin route alone.
And you're cutting... the sleeper?
www.theguardian.com/travel/2025/...
Intl Jet fuel tax exemptions are 80 years old and cost the EU 22 million EUR/yr for the Paris-Berlin route alone.
And you're cutting... the sleeper?
www.theguardian.com/travel/2025/...
Reposted
How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)
Molecular basis of polyadenylated RNA fate determination in the nucleus
Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...
www.biorxiv.org
September 22, 2025 at 11:23 PM
How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)
Reposted
My colleagues Baptise Rafanel et al. investigated how a newly invading transposon can be silenced. They found that not only antisense insertions in piRNA clusters such as flamenco, but also insertions in the 3‘UTR of genes can drive potent silencing.
Antisense transposon insertions into host genes trigger piRNA mediated immunity https://www.biorxiv.org/content/10.1101/2025.07.28.667215v1
August 2, 2025 at 8:36 PM
My colleagues Baptise Rafanel et al. investigated how a newly invading transposon can be silenced. They found that not only antisense insertions in piRNA clusters such as flamenco, but also insertions in the 3‘UTR of genes can drive potent silencing.
Our open source RT-LAMP paper is finally out! A major collaboration spanning two continents and wonderful contributions of many amazing people! You can read all about how we want to give diagnostics into the public domain here 👇
www.life-science-alliance.org/content/8/10...
www.life-science-alliance.org/content/8/10...
A lyophilized open-source RT-LAMP assay for molecular diagnostics in resource-limited settings
A critical bottleneck for equitable access to population-scale molecular diagnostics is the limited availability of rapid, inexpensive point-of-care tests, especially in low- and middle-income countri...
www.life-science-alliance.org
July 17, 2025 at 10:55 AM
Our open source RT-LAMP paper is finally out! A major collaboration spanning two continents and wonderful contributions of many amazing people! You can read all about how we want to give diagnostics into the public domain here 👇
www.life-science-alliance.org/content/8/10...
www.life-science-alliance.org/content/8/10...
Reposted
Novel open-source diagnostic tool offers affordable, reliable pathogen detection for resource-limited settings
Researchers have developed an open-source reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay that is lyophilized for heat stability and uses non-proprietary…
Researchers have developed an open-source reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay that is lyophilized for heat stability and uses non-proprietary…
Novel open-source diagnostic tool offers affordable, reliable pathogen detection for resource-limited settings
Researchers have developed an open-source reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay that is lyophilized for heat stability and uses non-proprietary components, making it an affordable tool for pathogen detection in diverse settings. Credit: 2025 Matl et al. Originally published in Life Science Alliance. 10.26508/lsa.202403167?PR A bottleneck in ensuring access to widespread molecular diagnostics, especially in low- and middle-income countries, has been the high cost and logistical complexities associated with rapid, point-of-care tests.
todayheadline.co
July 14, 2025 at 2:50 PM
Novel open-source diagnostic tool offers affordable, reliable pathogen detection for resource-limited settings
Researchers have developed an open-source reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay that is lyophilized for heat stability and uses non-proprietary…
Researchers have developed an open-source reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay that is lyophilized for heat stability and uses non-proprietary…
Reposted
A great collaborative effort of many labs across continents: @vbcscitraining.bsky.social, WACCBIP, TReND in Africa and more. Now a first paper on #open-source RT-LAMP #diagnostics is out: urldefense.com/v3/__https:/...
Congrats to the whole team. We hope this pushes affordable diagnostics in #LMICs
Congrats to the whole team. We hope this pushes affordable diagnostics in #LMICs
A lyophilized open-source RT-LAMP assay for molecular diagnostics in resource-limited settings
A critical bottleneck for equitable access to population-scale molecular diagnostics is the limited availability of rapid, inexpensive point-of-care tests, especially in low- and middle-income countri...
urldefense.com
July 16, 2025 at 7:25 AM
A great collaborative effort of many labs across continents: @vbcscitraining.bsky.social, WACCBIP, TReND in Africa and more. Now a first paper on #open-source RT-LAMP #diagnostics is out: urldefense.com/v3/__https:/...
Congrats to the whole team. We hope this pushes affordable diagnostics in #LMICs
Congrats to the whole team. We hope this pushes affordable diagnostics in #LMICs