Marta Garcia-Contreras
@martagarciacon2.bsky.social
Postdoc @mghcvrc @harvardmed @JohnsHopkins @Stanford_ChEMH |PhD @univmiami @UCV_svm |Founder @TheSecretome |CoChair @DPAC_JHPDA #FirstGen #extracellularvesicles #secretome #Diabetes #T1D #T2D #Obesity #Neuroendocrinology
🧵(5/5) Together, this work opens a path toward minimally invasive biomarkers of neuroinflammation. Excited to apply these tools in different neurodegenerative diseases and patient studies. ✨
November 25, 2025 at 4:36 PM
🧵(5/5) Together, this work opens a path toward minimally invasive biomarkers of neuroinflammation. Excited to apply these tools in different neurodegenerative diseases and patient studies. ✨
🧵(4/5) miR-146a-5p emerges as a consistent marker of pro-inflammatory activation across mouse + human iPSC microglia 🧫 and is detectable in microglial EVs during acute neuroinflammation.
November 25, 2025 at 4:36 PM
🧵(4/5) miR-146a-5p emerges as a consistent marker of pro-inflammatory activation across mouse + human iPSC microglia 🧫 and is detectable in microglial EVs during acute neuroinflammation.
🧵(3/5) Using our new ExoMap1 mouse 🐁 , we detect microglia-derived EVs in plasma for the first time. This lets us directly track CNS-derived vesicles in vivo.
November 25, 2025 at 4:36 PM
🧵(3/5) Using our new ExoMap1 mouse 🐁 , we detect microglia-derived EVs in plasma for the first time. This lets us directly track CNS-derived vesicles in vivo.
🧵(2/5) First We find that microglia release EVs and non-vesicular particles with distinct α2,6-sialylation and small RNA signatures 🧬that change with their activation state.
November 25, 2025 at 4:36 PM
🧵(2/5) First We find that microglia release EVs and non-vesicular particles with distinct α2,6-sialylation and small RNA signatures 🧬that change with their activation state.
🧵(1/5) Neuroinflammation drives many neurological diseases 🧠, but we still lack good non-invasive biomarkers. We asked: can microglia send detectable signals into the bloodstream🩸?
November 25, 2025 at 4:36 PM
🧵(1/5) Neuroinflammation drives many neurological diseases 🧠, but we still lack good non-invasive biomarkers. We asked: can microglia send detectable signals into the bloodstream🩸?
Could you please include me 😁
November 30, 2024 at 2:22 AM
Could you please include me 😁
Could I please be included? 🙋🏻♀️😊
November 21, 2024 at 2:45 PM
Could I please be included? 🙋🏻♀️😊
Could you please include me ? 😊🙋🏻♀️
November 18, 2024 at 3:32 PM
Could you please include me ? 😊🙋🏻♀️
Could you please include me!? 😊
November 18, 2024 at 5:03 AM
Could you please include me!? 😊
Could you please include me? 😊
November 18, 2024 at 4:42 AM
Could you please include me? 😊
Would love to join 🙋🏻♀️😊
November 18, 2024 at 4:15 AM
Would love to join 🙋🏻♀️😊
Would love to join 🙋🏻♀️😊
November 18, 2024 at 4:13 AM
Would love to join 🙋🏻♀️😊
Would love to join
November 18, 2024 at 4:11 AM
Would love to join
Would love to join 🙋🏻♀️
November 18, 2024 at 4:10 AM
Would love to join 🙋🏻♀️
Me 🙋🏻♀️😊
November 18, 2024 at 4:08 AM
Me 🙋🏻♀️😊