Mark Andermann
@markandermann.bsky.social
Neuroscientist. Canadian.
Congrats Marta on a very strong effort!
1️⃣
🥳 Thrilled to share that my postdoc work has finally hit the press!
www.nature.com/articles/s41...
When we started, we didn’t really know what PVH-MC4R neurons do in obesity.
Are they still signaling or “dead”? (e.g., does the chronically high leptin alter α-MSH–MC4R signaling?)
🧵👇
🥳 Thrilled to share that my postdoc work has finally hit the press!
www.nature.com/articles/s41...
When we started, we didn’t really know what PVH-MC4R neurons do in obesity.
Are they still signaling or “dead”? (e.g., does the chronically high leptin alter α-MSH–MC4R signaling?)
🧵👇
Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons - Scientific Reports
Scientific Reports - Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons
www.nature.com
October 16, 2025 at 1:41 AM
Congrats Marta on a very strong effort!
Reposted by Mark Andermann
NEW: Mark Andermann ( @markandermann.bsky.social) of @harvardmed.bsky.social brings experimental data and computational modeling together to understand cortical reactivations. Watch the video:
youtu.be/1N6i7Zi9kXs
#NeuroAI2025 #neuroscience #AI #NeuroAI
youtu.be/1N6i7Zi9kXs
#NeuroAI2025 #neuroscience #AI #NeuroAI
Offline Cortical Reactivations of Recent Experiences with Mark Andermann
Mark Andermann from Beth Isreal Deaconess Medical Center & Harvard Medical School joined the Frontiers of NeuroAI Symposium on June 6, 2025, to discuss "Offl...
youtu.be
June 11, 2025 at 4:32 PM
NEW: Mark Andermann ( @markandermann.bsky.social) of @harvardmed.bsky.social brings experimental data and computational modeling together to understand cortical reactivations. Watch the video:
youtu.be/1N6i7Zi9kXs
#NeuroAI2025 #neuroscience #AI #NeuroAI
youtu.be/1N6i7Zi9kXs
#NeuroAI2025 #neuroscience #AI #NeuroAI
Reposted by Mark Andermann
Out now in @nathumbehav.nature.com: Cuts to NIH funding will impact the economy and employment nationwide. We visualize these losses and advocate for a theory-driven approach to communicating local, self-relevant impact. w/ @joshuasweitz.bsky.social + SCIMaP team:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
NIH indirect cost cuts will affect the economy and employment - Nature Human Behaviour
Nature Human Behaviour - NIH indirect cost cuts will affect the economy and employment
www.nature.com
June 2, 2025 at 4:30 PM
Out now in @nathumbehav.nature.com: Cuts to NIH funding will impact the economy and employment nationwide. We visualize these losses and advocate for a theory-driven approach to communicating local, self-relevant impact. w/ @joshuasweitz.bsky.social + SCIMaP team:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Wild!
Stephen, Praneel and their team use fluorescence lifetime imaging and various manipulations to show that, in male mice, both mating drive and hypothalamic tonic dopamine release drop after a successful mating and gradually recover over the next week, paralleling the recovery in sperm count.
Stephen, Praneel and their team use fluorescence lifetime imaging and various manipulations to show that, in male mice, both mating drive and hypothalamic tonic dopamine release drop after a successful mating and gradually recover over the next week, paralleling the recovery in sperm count.
I am excited to share our preprint on how hypothalamic dopamine neurons govern slow changes in motivation over days! Below are our findings:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Slow-Timescale Regulation of Dopamine Release and Mating Drive over Days
The rise and fall of motivational states may take place over timescales as long as many days. We used mouse mating behavior to model how the brain orchestrates slow-timescale changes in motivation. Ma...
www.biorxiv.org
June 2, 2025 at 7:26 PM
Wild!
Stephen, Praneel and their team use fluorescence lifetime imaging and various manipulations to show that, in male mice, both mating drive and hypothalamic tonic dopamine release drop after a successful mating and gradually recover over the next week, paralleling the recovery in sperm count.
Stephen, Praneel and their team use fluorescence lifetime imaging and various manipulations to show that, in male mice, both mating drive and hypothalamic tonic dopamine release drop after a successful mating and gradually recover over the next week, paralleling the recovery in sperm count.
Disruption of visual cortical activity and offline reactivations of recent salient experience in the hours following training on a task associating cues with outcomes completely blocks across-day learning!
Exciting work by Kristian, Marianne and their team!
Exciting work by Kristian, Marianne and their team!
June 2, 2025 at 6:04 PM
Disruption of visual cortical activity and offline reactivations of recent salient experience in the hours following training on a task associating cues with outcomes completely blocks across-day learning!
Exciting work by Kristian, Marianne and their team!
Exciting work by Kristian, Marianne and their team!
We previously showed that specific hypothalamic neurons get more and more activated by each bite of food until they put a brake on homeostatic feeding. Here, we find that this brake is already on at the start of a meal in obese mice on a high-fat diet.
Congrats to Marta, Stephen and the whole team!
Congrats to Marta, Stephen and the whole team!
May 29, 2025 at 1:28 AM
We previously showed that specific hypothalamic neurons get more and more activated by each bite of food until they put a brake on homeostatic feeding. Here, we find that this brake is already on at the start of a meal in obese mice on a high-fat diet.
Congrats to Marta, Stephen and the whole team!
Congrats to Marta, Stephen and the whole team!
Reposted by Mark Andermann
Academic workers across the country are calling 📞 Legislators to ask them to sign on to bipartisan letters ✉️ in support of robust NIH funding and opposing the 15% indirect cost caps. Take 5 minutes to call your legislators today. Deadline is May 19th.
docs.google.com/document/d/1...
docs.google.com/document/d/1...
May 15, 2025 at 2:48 PM
Academic workers across the country are calling 📞 Legislators to ask them to sign on to bipartisan letters ✉️ in support of robust NIH funding and opposing the 15% indirect cost caps. Take 5 minutes to call your legislators today. Deadline is May 19th.
docs.google.com/document/d/1...
docs.google.com/document/d/1...
A drop of milkshake takes a wild ride as it passes through the body. Rachel and Kiersten and the team came up with cool strategies for visualizing food passing through the mouse GI tract and mapping the activity of the same 100s of brainstem neurons across weeks during feeding and other behaviors.
April 29, 2025 at 8:06 PM
A drop of milkshake takes a wild ride as it passes through the body. Rachel and Kiersten and the team came up with cool strategies for visualizing food passing through the mouse GI tract and mapping the activity of the same 100s of brainstem neurons across weeks during feeding and other behaviors.
Reposted by Mark Andermann
🚨iGluSnFR4 is finally out!🚨🧪
We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️
www.biorxiv.org/content/10.1...
🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX
#Neuroscience
We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️
www.biorxiv.org/content/10.1...
🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX
#Neuroscience
March 25, 2025 at 12:10 PM
🚨iGluSnFR4 is finally out!🚨🧪
We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️
www.biorxiv.org/content/10.1...
🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX
#Neuroscience
We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️
www.biorxiv.org/content/10.1...
🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX
#Neuroscience
Reposted by Mark Andermann
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
March 12, 2025 at 8:47 PM
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
Reposted by Mark Andermann
Don't miss the final opportunity to showcase your research with a poster presentation at Interoception at the @alleninstitute.bsky.social! Submit by March 4 (11:59pm MST). keysym.us/KSInterocept... youtu.be/424TJ_VTUCI
#KSInteroception25 @markandermann.bsky.social @ruimcosta.bsky.social
#KSInteroception25 @markandermann.bsky.social @ruimcosta.bsky.social
Interoception Promo Video
YouTube video by KeystoneSymposia
youtu.be
March 4, 2025 at 6:31 PM
Don't miss the final opportunity to showcase your research with a poster presentation at Interoception at the @alleninstitute.bsky.social! Submit by March 4 (11:59pm MST). keysym.us/KSInterocept... youtu.be/424TJ_VTUCI
#KSInteroception25 @markandermann.bsky.social @ruimcosta.bsky.social
#KSInteroception25 @markandermann.bsky.social @ruimcosta.bsky.social
Reposted by Mark Andermann
Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠
sciencehomecoming.com
sciencehomecoming.com
Science Homecoming
sciencehomecoming.com
February 18, 2025 at 5:12 PM
Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠
sciencehomecoming.com
sciencehomecoming.com
Stand Up for Science rally, March 7, 12-4 pm, Boston Common. Better than moping.
www.eventbrite.com/e/stand-up-f...
www.eventbrite.com/e/stand-up-f...
www.eventbrite.com
February 26, 2025 at 1:51 PM
Stand Up for Science rally, March 7, 12-4 pm, Boston Common. Better than moping.
www.eventbrite.com/e/stand-up-f...
www.eventbrite.com/e/stand-up-f...
We lack tools to rapidly track >1-2 changing signals in brain fluids. Peter Kalugin and an amazing team begin to address this challenge with simultaneous, real-time tracking of many (10+) neuromodulatory signals using Multiplexed Optical Recording of Sensors on a micro-Endoscope. Feedback welcome!
I’m thrilled to share our preprint presenting MORSE: a new way to simultaneously & quantitatively track patterns of neuromodulators/neuropeptides in vitro & in vivo using spatially multiplexed 3D imaging of 10+ green optical sensors on a microendoscope
biorxiv.org/content/10.1101/2025.01.26.634931v1
biorxiv.org/content/10.1101/2025.01.26.634931v1
January 27, 2025 at 2:01 PM
We lack tools to rapidly track >1-2 changing signals in brain fluids. Peter Kalugin and an amazing team begin to address this challenge with simultaneous, real-time tracking of many (10+) neuromodulatory signals using Multiplexed Optical Recording of Sensors on a micro-Endoscope. Feedback welcome!
Reposted by Mark Andermann
Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolution https://www.biorxiv.org/content/10.1101/2025.01.10.632162v1
January 12, 2025 at 11:15 PM
Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolution https://www.biorxiv.org/content/10.1101/2025.01.10.632162v1
Eight days left to submit your abstract for the 2025 Keystone Symposium on Brain Body Communication at the Allen Institute for Brain Science in Seattle! Join us in exploring the latest in interoception research. Please repost, thanks!
Happy holidays!
For those interested in brain body communication, the Keystone Symposium abstract deadline is approaching. I hope to see some of you soon!
For those interested in brain body communication, the Keystone Symposium abstract deadline is approaching. I hope to see some of you soon!
Come explore emerging research in brain-body communication
@KeystoneSymp
Interoception: Neural Sensing and Control of Organ Function, this April in Seattle! keysym.us/KSInterocept... #KSInteroception25 pic.x.com/gWsgQgcAJh
@KeystoneSymp
Interoception: Neural Sensing and Control of Organ Function, this April in Seattle! keysym.us/KSInterocept... #KSInteroception25 pic.x.com/gWsgQgcAJh
January 14, 2025 at 6:49 PM
Eight days left to submit your abstract for the 2025 Keystone Symposium on Brain Body Communication at the Allen Institute for Brain Science in Seattle! Join us in exploring the latest in interoception research. Please repost, thanks!
Happy holidays!
For those interested in brain body communication, the Keystone Symposium abstract deadline is approaching. I hope to see some of you soon!
For those interested in brain body communication, the Keystone Symposium abstract deadline is approaching. I hope to see some of you soon!
Come explore emerging research in brain-body communication
@KeystoneSymp
Interoception: Neural Sensing and Control of Organ Function, this April in Seattle! keysym.us/KSInterocept... #KSInteroception25 pic.x.com/gWsgQgcAJh
@KeystoneSymp
Interoception: Neural Sensing and Control of Organ Function, this April in Seattle! keysym.us/KSInterocept... #KSInteroception25 pic.x.com/gWsgQgcAJh
Interoception: Neural Sensing and Control of Organ Function | Keystone Symposia
keysym.us
December 26, 2024 at 11:28 AM
Happy holidays!
For those interested in brain body communication, the Keystone Symposium abstract deadline is approaching. I hope to see some of you soon!
For those interested in brain body communication, the Keystone Symposium abstract deadline is approaching. I hope to see some of you soon!
Reposted by Mark Andermann
The choroid plexus actively recruits immune cells during inflammation, according to a new study.
By @claudia-lopez.bsky.social
www.thetransmitter.org/neuroinflamm...
By @claudia-lopez.bsky.social
www.thetransmitter.org/neuroinflamm...
Immune cell interlopers breach—and repair—brain barrier in mice
The choroid plexus, the protective network of blood vessels and epithelial cells that line the brain’s ventricles, recruits neutrophils and macrophages during inflammation, a new study shows.
www.thetransmitter.org
November 20, 2024 at 3:03 PM
The choroid plexus actively recruits immune cells during inflammation, according to a new study.
By @claudia-lopez.bsky.social
www.thetransmitter.org/neuroinflamm...
By @claudia-lopez.bsky.social
www.thetransmitter.org/neuroinflamm...
Stephen Zhang and the team found that in vivo peptide release and signaling gradually enhances responses of satiety-promoting hypothalamic neurons to each bite of food. These consequences of each bite take minutes to manifest, and could help explain why slow eating enhances satiety. rdcu.be/dZlI3
Stochastic neuropeptide signals compete to calibrate the rate of satiation
Nature - Release of hunger-promoting and satiety-promoting neuropeptides drives opposing changes in the second messenger cAMP in awake mouse paraventricular hypothalamic MC4R neurons, thereby...
rdcu.be
November 16, 2024 at 11:41 AM
Stephen Zhang and the team found that in vivo peptide release and signaling gradually enhances responses of satiety-promoting hypothalamic neurons to each bite of food. These consequences of each bite take minutes to manifest, and could help explain why slow eating enhances satiety. rdcu.be/dZlI3
Come explore emerging research in brain-body communication
@KeystoneSymp
Interoception: Neural Sensing and Control of Organ Function, this April in Seattle! keysym.us/KSInterocept... #KSInteroception25 pic.x.com/gWsgQgcAJh
@KeystoneSymp
Interoception: Neural Sensing and Control of Organ Function, this April in Seattle! keysym.us/KSInterocept... #KSInteroception25 pic.x.com/gWsgQgcAJh
Interoception: Neural Sensing and Control of Organ Function | Keystone Symposia
keysym.us
November 16, 2024 at 11:35 AM
Come explore emerging research in brain-body communication
@KeystoneSymp
Interoception: Neural Sensing and Control of Organ Function, this April in Seattle! keysym.us/KSInterocept... #KSInteroception25 pic.x.com/gWsgQgcAJh
@KeystoneSymp
Interoception: Neural Sensing and Control of Organ Function, this April in Seattle! keysym.us/KSInterocept... #KSInteroception25 pic.x.com/gWsgQgcAJh