Marijne Vermeer
@marijnevermeer.bsky.social
Huge thanks to Sònia Tugues and the amazing @csparano.bsky.social, @ncoianiz.bsky.social, Maud Mayoux, Gioana Litscher, André Fonseca, Stanislav Dergun, Caroline Mussak, Lukas Rindlisbacher, @phaene.bsky.social, Laura Ducimetière, Tobias Wertheimer, Lothar Dieterich, @becherlab.bsky.social
October 29, 2025 at 10:16 AM
Huge thanks to Sònia Tugues and the amazing @csparano.bsky.social, @ncoianiz.bsky.social, Maud Mayoux, Gioana Litscher, André Fonseca, Stanislav Dergun, Caroline Mussak, Lukas Rindlisbacher, @phaene.bsky.social, Laura Ducimetière, Tobias Wertheimer, Lothar Dieterich, @becherlab.bsky.social
✨ We believe that understanding how NK cells operate in different environments brings us one step closer to harnessing their full potential against metastatic cancer.
October 29, 2025 at 10:09 AM
✨ We believe that understanding how NK cells operate in different environments brings us one step closer to harnessing their full potential against metastatic cancer.
In metastatic nodules, TGF-β signaling limits NK cells by inducing a dysfunctional, tissue-resident-like state.
Blocking TGF-β partially restores their effector function, pointing to a way to enhance anti-tumor immunity. 💥
Blocking TGF-β partially restores their effector function, pointing to a way to enhance anti-tumor immunity. 💥
October 29, 2025 at 10:06 AM
In metastatic nodules, TGF-β signaling limits NK cells by inducing a dysfunctional, tissue-resident-like state.
Blocking TGF-β partially restores their effector function, pointing to a way to enhance anti-tumor immunity. 💥
Blocking TGF-β partially restores their effector function, pointing to a way to enhance anti-tumor immunity. 💥
After this initial clearance phase, most CD11b⁺ NK cells remain intravascular and fail to track tumor cells that extravasate into the lung tissue.
Meanwhile, CD27⁺ NK cells infiltrate metastatic nodules more efficiently, but with a new environment come new challenges.
Meanwhile, CD27⁺ NK cells infiltrate metastatic nodules more efficiently, but with a new environment come new challenges.
October 29, 2025 at 10:01 AM
After this initial clearance phase, most CD11b⁺ NK cells remain intravascular and fail to track tumor cells that extravasate into the lung tissue.
Meanwhile, CD27⁺ NK cells infiltrate metastatic nodules more efficiently, but with a new environment come new challenges.
Meanwhile, CD27⁺ NK cells infiltrate metastatic nodules more efficiently, but with a new environment come new challenges.
We found that the lung vasculature hosts differentiated CD11b⁺ NK cells, that act as first responders and rapidly eliminate metastasizing tumor cells. ⚔️
October 29, 2025 at 9:58 AM
We found that the lung vasculature hosts differentiated CD11b⁺ NK cells, that act as first responders and rapidly eliminate metastasizing tumor cells. ⚔️
The lung is a common site of metastasis, but how immune cells protect it remains unclear.
❓We set out to uncover how NK cells patrol this environment, and why they sometimes lose their anti-tumor control.
❓We set out to uncover how NK cells patrol this environment, and why they sometimes lose their anti-tumor control.
October 29, 2025 at 9:53 AM
The lung is a common site of metastasis, but how immune cells protect it remains unclear.
❓We set out to uncover how NK cells patrol this environment, and why they sometimes lose their anti-tumor control.
❓We set out to uncover how NK cells patrol this environment, and why they sometimes lose their anti-tumor control.