María Mariner
@mariamafau.bsky.social
Postdoctoral researcher at @radaiglesiaslab.bsky.social | Developmental genomics | Prelighter (The Company of Biologists) | Artistic & Creative | Passionate about visual storytelling and design
Pinned
María Mariner
@mariamafau.bsky.social
· Jul 24
Thrilled to share the story stemming from my PhD!
We used mESC neural differentiation, genome editing and bulk & single-cell approaches to uncover how ZIC2 controls early neural fate by playing a dual and sequential regulatory role as a promiscous pioneer and a selective lineage-specific activator.
We used mESC neural differentiation, genome editing and bulk & single-cell approaches to uncover how ZIC2 controls early neural fate by playing a dual and sequential regulatory role as a promiscous pioneer and a selective lineage-specific activator.
Reposted by María Mariner
Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
www.biorxiv.org
November 18, 2025 at 2:51 PM
Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Reposted by María Mariner
IMPRS-BAC #gradschool: Our new groupleader @sedonamurphy.bsky.social has an open PhD project in her lab. Topic: Spatial feedback between epigenetic regulation and chromatin regulation. Apply by Jan 7, 2026!
👉 www.molgen.mpg.de/5091778/Murp...
👉 www.molgen.mpg.de/5091778/Murp...
November 18, 2025 at 4:05 PM
IMPRS-BAC #gradschool: Our new groupleader @sedonamurphy.bsky.social has an open PhD project in her lab. Topic: Spatial feedback between epigenetic regulation and chromatin regulation. Apply by Jan 7, 2026!
👉 www.molgen.mpg.de/5091778/Murp...
👉 www.molgen.mpg.de/5091778/Murp...
Reposted by María Mariner
🔔This Wednesday , in #FragileNucleosome seminar, we are excited to host @ishtiaqueh.bsky.social of Pastor lab and Prof. Sarah Teichmann, @teichlab.bsky.social, to tell us about their exciting studies!
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
November 18, 2025 at 9:43 AM
🔔This Wednesday , in #FragileNucleosome seminar, we are excited to host @ishtiaqueh.bsky.social of Pastor lab and Prof. Sarah Teichmann, @teichlab.bsky.social, to tell us about their exciting studies!
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
November 15, 2025 at 9:53 AM
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Reposted by María Mariner
OFERTA DE EMPLEO (por favor difundir):
Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas
👇
Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas
👇
November 6, 2025 at 5:24 PM
OFERTA DE EMPLEO (por favor difundir):
Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas
👇
Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas
👇
Reposted by María Mariner
2nd Meeting on Early Embryogenesis and Epigenetics
16 - 18 Feb 2026 at MPI for Molecular Genetics, Berlin
with support by the Weizmann Institute for Science.
Early bird registration until 30 Sep - register now👇
www.molgen.mpg.de/embryo2026
16 - 18 Feb 2026 at MPI for Molecular Genetics, Berlin
with support by the Weizmann Institute for Science.
Early bird registration until 30 Sep - register now👇
www.molgen.mpg.de/embryo2026
September 26, 2025 at 1:09 PM
2nd Meeting on Early Embryogenesis and Epigenetics
16 - 18 Feb 2026 at MPI for Molecular Genetics, Berlin
with support by the Weizmann Institute for Science.
Early bird registration until 30 Sep - register now👇
www.molgen.mpg.de/embryo2026
16 - 18 Feb 2026 at MPI for Molecular Genetics, Berlin
with support by the Weizmann Institute for Science.
Early bird registration until 30 Sep - register now👇
www.molgen.mpg.de/embryo2026
Reposted by María Mariner
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
September 8, 2025 at 3:15 PM
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
Reposted by María Mariner
Axolotl (Ambystoma mexicanum)🦎 can regrow limbs, tail, spinal cord, heart, and even parts of its brain. Axolotls are champions of regeneration and also shed light on limb patterning, wound healing, and developmental plasticity. Image from Prayag Murawala #ModelMonday #DevBio
September 2, 2025 at 12:11 AM
Axolotl (Ambystoma mexicanum)🦎 can regrow limbs, tail, spinal cord, heart, and even parts of its brain. Axolotls are champions of regeneration and also shed light on limb patterning, wound healing, and developmental plasticity. Image from Prayag Murawala #ModelMonday #DevBio
Honoured to be part of this awesome lineup 😍! @fnucleosome.bsky.social thanks for the opportunity! A very exciting Fall Season is about to start, I wouldn't miss it 😌🧬
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
September 2, 2025 at 8:56 AM
Honoured to be part of this awesome lineup 😍! @fnucleosome.bsky.social thanks for the opportunity! A very exciting Fall Season is about to start, I wouldn't miss it 😌🧬
Reposted by María Mariner
We are searching for a research technician in our group at EMBL Heidelberg! 🧫🧬🔬
For more details, see the ad. Please reach out in case of any questions.
The position is ideally filled by October 1.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
For more details, see the ad. Please reach out in case of any questions.
The position is ideally filled by October 1.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Research Technician
We are looking for a highly motivated research technician to join the Zaugg group at EMBL Heidelberg, an interdisciplinary team of experimental and computational scientists. Our research combines larg...
embl.wd103.myworkdayjobs.com
September 1, 2025 at 7:37 AM
We are searching for a research technician in our group at EMBL Heidelberg! 🧫🧬🔬
For more details, see the ad. Please reach out in case of any questions.
The position is ideally filled by October 1.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
For more details, see the ad. Please reach out in case of any questions.
The position is ideally filled by October 1.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by María Mariner
#Preprint alert! 📣
We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements
www.biorxiv.org/cgi/content/...
We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements
www.biorxiv.org/cgi/content/...
MLL2 facilitates long-range gene regulation through LINE1 elements
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 d...
www.biorxiv.org
August 13, 2025 at 5:54 AM
#Preprint alert! 📣
We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements
www.biorxiv.org/cgi/content/...
We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements
www.biorxiv.org/cgi/content/...
🗒️‼️Do not miss this exciting new #preprint from the @radaiglesiaslab.bsky.social, led by @eharo84.bsky.social: a master of building synergy ⏫- both in #enhancer research and at the lab! #DarkGenome #Transcription #GeneRegulation #Development #Genomics
Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Synthetic engineering demonstrates that synergy among enhancers involves an increase in transcriptionally productive enhancer-gene contacts
Enhancers are non-coding cis-regulatory elements that control the expression of distally located genes in a tissue- and time-specific manner. Recent studies indicate that enhancers can differ in their...
www.biorxiv.org
August 11, 2025 at 4:16 PM
🗒️‼️Do not miss this exciting new #preprint from the @radaiglesiaslab.bsky.social, led by @eharo84.bsky.social: a master of building synergy ⏫- both in #enhancer research and at the lab! #DarkGenome #Transcription #GeneRegulation #Development #Genomics
Reposted by María Mariner
#JobOffer
#cienciajobs
Postdoctoral position at the #CABD working with the amazing and dynamic team of @crisprscan.bsky.social ✂️🧬🐟
📍Sevilla, Spain
Apply or share
@sebioldev.bsky.social @segenetica.bsky.social @sebbm.bsky.social
#cienciajobs
Postdoctoral position at the #CABD working with the amazing and dynamic team of @crisprscan.bsky.social ✂️🧬🐟
📍Sevilla, Spain
Apply or share
@sebioldev.bsky.social @segenetica.bsky.social @sebbm.bsky.social
July 24, 2025 at 8:24 PM
#JobOffer
#cienciajobs
Postdoctoral position at the #CABD working with the amazing and dynamic team of @crisprscan.bsky.social ✂️🧬🐟
📍Sevilla, Spain
Apply or share
@sebioldev.bsky.social @segenetica.bsky.social @sebbm.bsky.social
#cienciajobs
Postdoctoral position at the #CABD working with the amazing and dynamic team of @crisprscan.bsky.social ✂️🧬🐟
📍Sevilla, Spain
Apply or share
@sebioldev.bsky.social @segenetica.bsky.social @sebbm.bsky.social
Thrilled to share the story stemming from my PhD!
We used mESC neural differentiation, genome editing and bulk & single-cell approaches to uncover how ZIC2 controls early neural fate by playing a dual and sequential regulatory role as a promiscous pioneer and a selective lineage-specific activator.
We used mESC neural differentiation, genome editing and bulk & single-cell approaches to uncover how ZIC2 controls early neural fate by playing a dual and sequential regulatory role as a promiscous pioneer and a selective lineage-specific activator.
July 24, 2025 at 4:28 PM
Thrilled to share the story stemming from my PhD!
We used mESC neural differentiation, genome editing and bulk & single-cell approaches to uncover how ZIC2 controls early neural fate by playing a dual and sequential regulatory role as a promiscous pioneer and a selective lineage-specific activator.
We used mESC neural differentiation, genome editing and bulk & single-cell approaches to uncover how ZIC2 controls early neural fate by playing a dual and sequential regulatory role as a promiscous pioneer and a selective lineage-specific activator.
Reposted by María Mariner
⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.
June 23, 2025 at 7:51 AM
⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.
Just visited the pond where my passion for developmental biology began🥹. No tadpoles in sight, but I did spot these handsome little guys. Counted over 30 frogs 🐸—most of them covered in moist soil, undergoing estivation!🥵🌄
June 24, 2025 at 6:15 PM
Just visited the pond where my passion for developmental biology began🥹. No tadpoles in sight, but I did spot these handsome little guys. Counted over 30 frogs 🐸—most of them covered in moist soil, undergoing estivation!🥵🌄
CAR-T therapy dev is on fire! Still remember covering the ARI project (Clínic Bcn-IDIBAPS) as an assignment during my Biotech days at UPV—I am sure Ariana would be smiling, excited to see how fast the field is moving to make the treatment she dreamt of simpler and more accessible.🧡
Manufacturing CAR T cells in the laboratory is expensive and time-consuming.
An in vivo approach could get this powerful therapy to more people
https://go.nature.com/45w5A5w
An in vivo approach could get this powerful therapy to more people
https://go.nature.com/45w5A5w
Cancer-fighting immune cells could soon be engineered inside our bodies
Nature - Manufacturing CAR T cells in the laboratory is expensive and time-consuming. An in vivo approach could get the powerful therapy to more people.
go.nature.com
May 31, 2025 at 3:51 PM
CAR-T therapy dev is on fire! Still remember covering the ARI project (Clínic Bcn-IDIBAPS) as an assignment during my Biotech days at UPV—I am sure Ariana would be smiling, excited to see how fast the field is moving to make the treatment she dreamt of simpler and more accessible.🧡
I wouldn't miss it if attending to #ESHG2025!
Ready and excited to start with #ESHG2025. If you want to hear about how developmental genes can contribute to the insulation of their own TADs, and the consequences for SV interpretation, find me on P22.020.A poster on Sunday 13:00-14:00. Special thanks to the best host @mattetrovato.bsky.social ❤️
May 24, 2025 at 5:04 AM
I wouldn't miss it if attending to #ESHG2025!
#EMBLChromatin keeps being awesome: fantastic talks, lots of networking and troubleshooting! But guess who is also multitasking? ZIC2! Particularly during neural induction! Come by this afternoon to check poster 158 and I’ll tell you all about it 😉 @radaiglesiaslab.bsky.social
May 15, 2025 at 8:08 AM
#EMBLChromatin keeps being awesome: fantastic talks, lots of networking and troubleshooting! But guess who is also multitasking? ZIC2! Particularly during neural induction! Come by this afternoon to check poster 158 and I’ll tell you all about it 😉 @radaiglesiaslab.bsky.social
Reposted by María Mariner
#Enhancer folks, submit your abstracts and register soon! Deadlines are around the corner and there are many opportunities for short talks.
February 26, 2025 at 6:23 AM
#Enhancer folks, submit your abstracts and register soon! Deadlines are around the corner and there are many opportunities for short talks.
🔬💜 #11F, what a day! 💜🔬
Yesterday we brought science to the classroom.
As we left, 3 girls said they wanted to become scientists👩🔬. For you and for all those who will come after you: we’ll keep fighting to make sure you get there!
#WomenAndGirlsInScience
Yesterday we brought science to the classroom.
As we left, 3 girls said they wanted to become scientists👩🔬. For you and for all those who will come after you: we’ll keep fighting to make sure you get there!
#WomenAndGirlsInScience
February 12, 2025 at 6:12 PM
🔬💜 #11F, what a day! 💜🔬
Yesterday we brought science to the classroom.
As we left, 3 girls said they wanted to become scientists👩🔬. For you and for all those who will come after you: we’ll keep fighting to make sure you get there!
#WomenAndGirlsInScience
Yesterday we brought science to the classroom.
As we left, 3 girls said they wanted to become scientists👩🔬. For you and for all those who will come after you: we’ll keep fighting to make sure you get there!
#WomenAndGirlsInScience