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marco.heinlab.org
Marco Hein
@marco.heinlab.org
1.4K followers 2.4K following 26 posts
Systems biologist • Prof at Max Perutz Labs & MedUni Vienna • dad×2 • he/him
#LoveVirology #TeamMassSpec #dataviz
📍 Vienna 🇪🇺
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marco.heinlab.org
Marco Hein @marco.heinlab.org · Jan 14
Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/

1/3 🧪
Graphical abstract of the Organelle Profiling paper, showing the workflow: Endogenously tagged organelle library; Native IP proteomics; Data-driven graph clustering; resulting in a subcellular proteome map with more than 7,600 proteins localized across 19 subcellular compartments.
Reposted by Marco Hein
imbavienna.bsky.social
🎉 Congratulations to Max Kellner, former PhD student in the Penninger Lab, who was presented with the ÖGBMT Life Sciences PhD Award Austria. The award recognizes Kellner’s PhD research on how dangerous viruses emerge from natural reservoirs like bats. More: https://imba.science/3KiRYSN
September 25, 2025 at 11:00 AM
Reposted by Marco Hein
vbcscitraining.bsky.social
Our Autumn call is now open with over 20+ fully funded positions in various disciplines in the life sciences. Interested? Check out our vacancies in computational biology, genomes & evolution and the exciting projects being offered here: ow.ly/aBgQ50WY1S2
September 17, 2025 at 12:00 PM
marco.heinlab.org
I couldn’t be prouder of my team! Kavya and Sebastian both won DOC fellowships from the Austrian Academy of Sciences!
Congratulations to all awardees!
maxperutzlabs.ac.at Max Perutz Labs Vienna @maxperutzlabs.ac.at · Jul 15
The DOC-torate dream team! 🎓 Seven Perutz PhD students just secured @oeaw.bsky.social DOC Fellowships - the most we've ever had in one year! Huge Congrats! 🎉➡️ tinyurl.com/29nvtf7j

@univie.ac.at
@meduniwien.ac.at
July 15, 2025 at 7:34 PM
Reposted by Marco Hein
golobor.bsky.social
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
July 15, 2025 at 8:11 AM
marco.heinlab.org
Join us at the Perutz, part of the Vienna Biocenter!
Opening for a full professorship in Molecular Mechanisms of Disease 👇🏻
@maxperutzlabs.bsky.social @viennabiocenter.bsky.social
@univie.ac.at
maxperutzlabs.ac.at Max Perutz Labs Vienna @maxperutzlabs.ac.at · Jul 7
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Molecular Mechanisms of Disease. More information ➡️ tinyurl.com/3yn883b8
July 8, 2025 at 12:25 PM
Reposted by Marco Hein
chribue.bsky.social
Exciting and rare opportunity to join the @maxperutzlabs.bsky.social and the @viennabiocenter.bsky.social as a Full Professor!
www.nature.com/naturecareer...
Full Professorship in Molecular Mechanisms of Disease - Vienna BioCenter, Austria job with Max Perutz Labs, University of Vienna | 12841053
Join theMax Perutz Labs as Full Professor to unravel disease mechanisms—from metabolism and stress to RNA regulation, epigenetics, and immunity.
www.nature.com
July 2, 2025 at 7:19 AM
Reposted by Marco Hein
jnoms.bsky.social
Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!
June 12, 2025 at 8:31 PM
Reposted by Marco Hein
shiraweingarten.bsky.social
If you love #viruses, #ribosomes, and genomic #darkmatter, this thread is for you!! 💫
We're excited to share our new publication developing Massively Parallel Ribosome Profiling (MPRP), which uncovered ~4,000 hidden proteins in ~700 viral genomes. www.science.org/doi/10.1126/...
June 12, 2025 at 9:19 PM
Reposted by Marco Hein
xkcd.com
Mass Spec

xkcd.com/3094/
[Person with ponytail wearing lab coat hands balloon to another person in front of a springboard, a magnet hanging from above, and then a target] PERSON WITH PONYTAIL to Person 2: Rub this balloon against your head, then go jump past that magnet toward the target on the wall. [caption] Before the bathroom scale was invented, the only way to weigh people was mass spectrometry.
May 29, 2025 at 7:26 PM
Reposted by Marco Hein
mjkellner.bsky.social
Hi 🦋 I’m thrilled to share that our #bat #organoid work has found a publishing home in Nature Immunology!

These models provided unprecedented insight into antiviral immunity at epithelial surfaces of the Egyptian fruit bat 🦇 — a natural reservoir of Marburg virus 🦠

www.nature.com/articles/s41...
Bat organoids reveal antiviral responses at epithelial surfaces - Nature Immunology
Kellner et al. develop respiratory and intestinal organoids from Rousettus aegyptiacus to show elevated basal expression of interferon-ε (IFNε) and IFN-stimulated genes, along with robust, self-amplifying type III IFN responses that drive antiviral defense against zoonotic RNA viruses.
www.nature.com
May 21, 2025 at 7:14 PM
Reposted by Marco Hein
meduniwien.ac.at
Innovative Forschung zur Entstehung & Kontrolle von #Metastasen ⤵️

Wir gratulieren @jwinkler.bsky.social von der #MedUniWien zur Auszeichnung der @oeaw.bsky.social mit dem Johann Wilhelm Ritter von Mannagetta-Preis!
Juliane Winkler mit dem Johann Wilhelm Ritter von Mannagetta-Preis ausgezeichnet
Mehr über die Studie zur Entstehung von Metastasen!
www.meduniwien.ac.at
May 6, 2025 at 6:41 AM
Reposted by Marco Hein
jwinkler.bsky.social
🌟 Exciting #PhD Opportunity! Join my lab in beautiful #Vienna. We are studying tumor-immune interactions in #metastasis using #singlecell and #spatial omics! ⏰ Apply by 04/25 bit.ly/3l7WMhs more infos 👉 winklerlab.org
April 7, 2025 at 11:24 AM
Reposted by Marco Hein
mmbronstein.bsky.social
Aithyra is hiring! We are looking for multiple starting PIs in life sciences and AI/ML. We offer highly competitive packages and salaries among the highest in Europe.

www.oeaw.ac.at/aithyra/news...
Search for LIFE SCIENCE and AI/ML Starting Principal Investigators (m/f/d) at AITHYRA, Vienna
If you are an ambitious early-career scientist ready to propel your research to new heights, we invite you to be part of AITHYRA’s founding generation of Principal Investigators. Together, we will sha...
www.oeaw.ac.at
March 17, 2025 at 8:07 PM
Reposted by Marco Hein
imbavienna.bsky.social
IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.
March 28, 2025 at 11:15 AM
marco.heinlab.org
Dear @nature.com publishing group:
We swallowed your $12k article processing charge, but the name of your new journal is too much…
Screenshot of the “aims and scope” page of the fictitious journal “Nature Cell Science” [April fools]
April 1, 2025 at 2:24 PM
Reposted by Marco Hein
mayavoichek.bsky.social
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte
March 17, 2025 at 11:56 AM
Reposted by Marco Hein
vbcscitraining.bsky.social
Our Spring call is now open with over 25+ fully funded positions in various disciplines in the life sciences. Interested? Check out our vacancies and the exciting projects being offered here: www.vbcphd.at
Application Deadline: 15 April 2025
March 6, 2025 at 4:19 PM
Reposted by Marco Hein
datavisfriendly.bsky.social
📊Looking to re-decorate your #dataviz office?
You need Boxplot Shelves! |----[ ]--|
A set of three wall shelf sets, in the form of boxplots
March 5, 2025 at 3:13 AM
Reposted by Marco Hein
abbybuch.bsky.social
Heading to my SF local #standupforscience rally tomorrow along with many UCSF colleagues and friends. Making signs this afternoon at departmental happy hour hosted by @elphegenoralab.bsky.social - we need inspiration!
March 6, 2025 at 8:00 PM
Reposted by Marco Hein
bpodaily.bsky.social
A high-res approach to localise thousands of proteins within a cell

📷: Marco Hein, Duo Peng, Verina Todorova, Frank McCarthy, Kibeom Kim, Chad Liu et al @czbiohub.bsky.social in @cellpress.bsky.social
➡️: bpod.org.uk/archive/2025/2/22 with
@rooph.bsky.social
February 24, 2025 at 9:02 AM
marco.heinlab.org
Join me tomorrow 4 Feb at 14:00 CET for an educational seminar about single-cell transcriptomics in virology:
Register here: us06web.zoom.us/meeting/regi...

This is seminar 1 of the new season of @gesvirologie.bsky.social's ACHIEVE Academy's 'How-To' seminars, targeted at PhD and Master's students.
Announcement poster for Marco Hein's seminar 'How to perform and analyze single-cell sequencing"
February 3, 2025 at 8:50 AM
Reposted by Marco Hein
imbavienna.bsky.social
Congratulations to Max Kellner (Penninger Group) on the completion of his PhD! Max presented his work on molecular virus diagnostics for resource-limited settings and, separately, on modeling host-virus interactions in natural reservoir species using bat organoids.
January 31, 2025 at 11:25 AM
Reposted by Marco Hein
maxperutzlabs.ac.at
📑 New study out now! The Kovarik lab uncovers a novel mechanism for eliminating pro-inflammatory pre-mRNAs in the nucleus - preventing the overproduction of cytokines published in Molecular Cell ➡️ tinyurl.com/m8p87k6k

@univie.ac.at
January 30, 2025 at 9:01 AM
marco.heinlab.org
Congratulations Elif and Shotaro 🥳
maxperutzlabs.ac.at Max Perutz Labs Vienna @maxperutzlabs.ac.at · Jan 29
Congrats to Perutz group leaders Elif Karagöz and @shotarootsuka.bsky.social on becoming tenured professors 🎉 Since 2019, the Karagöz lab has been uncovering how cells maintain protein homeostasis, while the Otsuka lab explores how the ER and nucleus communicate ➡️ tinyurl.com/2phzhprj
January 29, 2025 at 10:13 AM
Reposted by Marco Hein
maxperutzlabs.ac.at
🎉 Congrats to @marcoyannic.bsky.social on securing a WWTF grant! Partnering with Irene Görzer from the Medical University of Vienna, Marco will delve into the largely unexplored world of anelloviruses - ubiquitous, commensal members of the human virome 🦠 Read more ➡️ tinyurl.com/yk5zfcmh
January 16, 2025 at 10:48 AM