Marc Duque Ramirez
@marcduque.bsky.social
NeuroPhD candidate @Engert Lab. Interested in new neuromodulation techniques and molecular approaches to understand how the brain works.
3/3 We haven't tested in fish yet, but I wonder if there would be a significant difference in the glial calcium effect between DXM alone and DXM + bup. Thanks again for bringing this up!
December 22, 2024 at 11:57 AM
3/3 We haven't tested in fish yet, but I wonder if there would be a significant difference in the glial calcium effect between DXM alone and DXM + bup. Thanks again for bringing this up!
2/3 I also wondered if this could explain the observed synergy between NMDAR antagonism and NE reuptake inhibition, such as with DXM and bupropion, although I'm sure there's many different mechanisms at play.
December 22, 2024 at 11:57 AM
2/3 I also wondered if this could explain the observed synergy between NMDAR antagonism and NE reuptake inhibition, such as with DXM and bupropion, although I'm sure there's many different mechanisms at play.
1/3 That is fascinating thanks so much for sharing! Looking forward to what you see in terms of non-responders for prazosin and other alpha-1 antagonists.
December 22, 2024 at 11:57 AM
1/3 That is fascinating thanks so much for sharing! Looking forward to what you see in terms of non-responders for prazosin and other alpha-1 antagonists.