Manish Kushwaha
@manishmicrobe.bsky.social
Research Director at the Micalis Institute, INRAE-AgroParisTech, University of Paris-Saclay. Research interests: Synthetic Biology, Biological Computing, Bioengineering.
https://cellularcomputing.team/
https://manishkushwaha.net/
https://cellularcomputing.team/
https://manishkushwaha.net/
Great collaboration with co-authors Maud Hofmann, Farouk Abdo, and @oborkowski.bsky.social.
October 2, 2025 at 8:02 AM
Great collaboration with co-authors Maud Hofmann, Farouk Abdo, and @oborkowski.bsky.social.
It was a great session!! Thanks for organising it @vdlorenzo.bsky.social @angelgm.bsky.social
July 15, 2025 at 9:50 PM
It was a great session!! Thanks for organising it @vdlorenzo.bsky.social @angelgm.bsky.social
Thanks, Alex. There's definitely those challenges with CRISPRi circuits. In our hands a big issue with scaling up seemed to be multiple message delivery. As the number of input signals increased, so did the circuit activation time. Lots more to do, including libraries!
December 29, 2024 at 9:46 AM
Thanks, Alex. There's definitely those challenges with CRISPRi circuits. In our hands a big issue with scaling up seemed to be multiple message delivery. As the number of input signals increased, so did the circuit activation time. Lots more to do, including libraries!
Phages in biological computing have great potential, as was highlighted by @drewendy.bsky.social in doi.org/10.1186/1754.... A recent preprint from the @yschaerli.bsky.social lab also uses inducible phage messages for intercellular communication and CRISPRi. doi.org/10.1101/2024...
Engineered cell-cell communication via DNA messaging - Journal of Biological Engineering
Background Evolution has selected for organisms that benefit from genetically encoded cell-cell communication. Engineers have begun to repurpose elements of natural communication systems to realize pr...
jbioleng.biomedcentral.com
December 28, 2024 at 8:39 AM
Phages in biological computing have great potential, as was highlighted by @drewendy.bsky.social in doi.org/10.1186/1754.... A recent preprint from the @yschaerli.bsky.social lab also uses inducible phage messages for intercellular communication and CRISPRi. doi.org/10.1101/2024...
Grateful 🙏🙏 for all the feedback received during the different presentations over the past year: SynBio UK 2023, Gogec 2024, BioSynSys 2024, and the SynBYSS seminar series.
December 28, 2024 at 8:35 AM
Grateful 🙏🙏 for all the feedback received during the different presentations over the past year: SynBio UK 2023, Gogec 2024, BioSynSys 2024, and the SynBYSS seminar series.
This was a multi-year effort by a great team: Abhinav Pujar, Amit Pathania, Corbin Hopper, Amir Pandi, @biocriss.bsky.social, Matthias Függer, Thomas Nowak.
December 28, 2024 at 8:34 AM
This was a multi-year effort by a great team: Abhinav Pujar, Amit Pathania, Corbin Hopper, Amir Pandi, @biocriss.bsky.social, Matthias Függer, Thomas Nowak.
Growth phase and resource competition impacted communication efficiency between senders and receivers. Expanded orthogonality by using DNA messages for i-CRISPRi enabled us to build several multicellular logic gates (single- and dual-rail encoding): NOT, YES, AND, AND-AND-NOT.
December 28, 2024 at 8:32 AM
Growth phase and resource competition impacted communication efficiency between senders and receivers. Expanded orthogonality by using DNA messages for i-CRISPRi enabled us to build several multicellular logic gates (single- and dual-rail encoding): NOT, YES, AND, AND-AND-NOT.