Makoto T Hayashi
@makotothayashi.bsky.social
Group leader at IFOM-KU joint lab is working on #chromosome biology, especially focusing on #telomere functions. Employed by IFOM ETS and running the lab at Kyoto University.
5/10 Our study uncovers a sophisticated mechanism involving the Chromosome Passenger Complex (CPC), the shelterin complex, and the BLM-TOP3A-RMI1/2 (BTR) complex in regulating MAD-telomere deprotection.
March 17, 2025 at 12:49 PM
5/10 Our study uncovers a sophisticated mechanism involving the Chromosome Passenger Complex (CPC), the shelterin complex, and the BLM-TOP3A-RMI1/2 (BTR) complex in regulating MAD-telomere deprotection.
4/10 Telomeres safeguard chromosome ends by forming t-loops, preventing ATM activation and unwarranted DNA damage responses (DDR). However, during mitotic arrest, telomere linearity and a localized DDR emerge—a phenomenon known as "Mitotic Arrest Dependent (MAD)-Telomere Deprotection."
March 17, 2025 at 12:49 PM
4/10 Telomeres safeguard chromosome ends by forming t-loops, preventing ATM activation and unwarranted DNA damage responses (DDR). However, during mitotic arrest, telomere linearity and a localized DDR emerge—a phenomenon known as "Mitotic Arrest Dependent (MAD)-Telomere Deprotection."