MAGIC
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magic-horizon.bsky.social
MAGIC
@magic-horizon.bsky.social
Accelerating the development of gene therapies for muscular dystrophies. Funded by @horizoneu.bsky.social, @ukri.org and Swiss State Secretariat for Education, Research and Innovation (SERI)
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MAGIC aims to develop effective treatments for people living with rare muscular dystrophies.

These rare conditions affect the muscles and can impact walking, eating, sleeping and breathing.

Bringing together leading experts we will push research forwards, faster.🧑‍🔬

#musculardystrophy #genetherapy
🔬 Curious about the latest progress in gene therapy for muscular dystrophies?

The #MAGICproject is publishing impactful research, scientific tools & resources for the wider community.

🧬 Explore open-access papers, abstracts, and key findings here:

👉 magic-horizon.eu
November 26, 2025 at 12:28 PM
Last month, MAGIC partners met in Lisbon for our annual General Assembly at GIMM.

Discussions focused on:
• Improving AAV delivery for gene therapy
• Gene editing beyond mutation correction
• 3D muscle models to accelerate testing

Read more: magic-horizon.eu/news/magic-g...
November 20, 2025 at 12:48 PM
✨ What is MAGIC and why does it matter for gene therapy?

PI
@SaverioTedesco
shares how this multi-partner project tackles key challenges in rare neuromuscular conditions – building building tools for safer, more effective treatments.

🎥 Watch below

#GeneTherapy #RareDisease
November 18, 2025 at 9:39 AM
What’s next for gene therapy?

Our workshop brought researchers together for a Q&A with MAGIC experts Eduard Ayuso, David-Alexandre Gross, Gabriela Silve & Odile Boespflug-Tanguy.

From delivery challenges to emerging tech, the future looks bold.

#GeneTherapy
November 5, 2025 at 4:29 PM
🚨 MAGIC Project General Assembly! 🚨

Consortium partners are gathering to:

✅ Share progress
✅ Strengthen collaboration
✅ Align on next steps

We’re driving innovation in neuromuscular disease & gene therapy – and building momentum for the year ahead. 🚀

#ResearchProgress
October 28, 2025 at 10:10 AM
Proud to host today’s MAGIC Project workshop in Lisbon, where experts are discussing:

🔬Muscle on a Chip
🧬Gene Editing
💉Viral Transduction
🧫Vector Production

We're sharing knowledge with the wider research community to accelerate progress in #genetherapy.
October 27, 2025 at 3:36 PM
🔬 Earlier this month at #ESGCT2025, MAGIC partners
@crick.ac.uk
shared 3 posters on human models for neuromuscular gene therapy:

🧪 3D cultures for DMD
🧠 AAV dynamics in multi-organoids
🧬 Myotubular myopathy modelling

Pushing boundaries in patient-relevant research.

#genetherapy #MagicProject
October 22, 2025 at 8:30 AM
🔬 MAGIC at #ESGCT2025!

DINAMIQS shared how mass photometry boosts AAV packaging efficiency & stability.

📌 >95% full capsids = better stress resilience.
🚀 Fast, label-free AAV quality checks = smarter upstream optimisation.

#MAGICProject #GeneTherapy #AAV
October 16, 2025 at 9:54 AM
Great to see Francesco Saverio Tedesco presenting the latest results from the MAGIC project at #WMS2025 in Vienna this morning.

Fantastic to see this international collaboration represented on the global stage 🌍🧬

#genetherapy #3Dmusclemodels
October 10, 2025 at 12:21 PM
Are you attending #WMS2025 or #ESGCT2025 this week? 🔬

Make sure you check out the presentations from MAGIC members to learn more about the project and how we’re aiming to accelerate the development of gene therapies for rare neuromuscular conditions.

🧵⬇️
October 8, 2025 at 11:58 AM
Headed to #WMS2025 or #ESGCT2025 next week? 🧬✈️

Members from MAGIC will be attending both – keep an eye out for posters and presentations to learn more about the project.

We’re looking forward to connecting with researchers, clinicians, and collaborators across both events! 🤝
October 2, 2025 at 9:32 AM
In the MAGIC project, we’re building modular 3D muscle models for conditions like FSHD, Duchenne & congenital myopathies.

🧬 Tailored cell sources
🧱 Custom matrix design
📊 Relevant functional readouts

All within a scalable, reproducible platform.

🔗 magic-horizon.eu
September 25, 2025 at 8:09 AM
Rare neuromuscular diseases demand global collaboration. 🌍

The MAGIC project unites researchers worldwide to advance next-gen genetic therapies.

Our project leaflets, now in 6 languages, outline our goals and translational potential.

📄 Download: magic-horizon.eu/media/leafle...

#RareDisease
September 17, 2025 at 8:07 AM
We’re building next-gen 3D muscle models in the MAGIC Project 🧬

🔬 Patient-derived cells
💧 Microfluidics
🧫 3D tissue architecture

Designed to better predict how gene therapies will work in rare neuromuscular diseases.

🔗 magic-horizon.eu

#GeneTherapy
September 10, 2025 at 1:15 PM
🔬 Curious about the latest progress in gene therapy for muscular dystrophies?

The #MAGICproject is publishing impactful research, scientific tools & resources for the wider community.

🧬 Explore open-access papers, abstracts, and key findings here:
👉 magic-horizon.eu
#GeneTherapy #RareDisease
August 27, 2025 at 8:47 AM
🚨 New publication from the #MAGICproject!

A novel iPSC line from a UCMD patient with a COL6A1 mutation offers a valuable new model for studying collagen VI-related muscular dystrophies and testing therapies.

📖 Read the paper: www.sciencedirect.com/science/arti...
August 6, 2025 at 8:09 AM
Developing gene therapies for rare muscular dystrophies comes with big challenges:

🔬 Lack of realistic muscle models
🧫 Targeted delivery without triggering immune responses

Mariam Zhouhair (‪@crick.ac.uk) shares how the MAGIC project is tackling these.

🔗 magic-horizon.eu/news/meet-cr...
July 30, 2025 at 7:58 AM
📫 Our next newsletter is landing in inboxes soon!

Subscribe to hear about the latest developments from the #MAGICproject:

🔬 Genetic therapies advances for muscular dystrophies
📰 Conference & event highlights
📝 New research publications
…& more!

👉 magic-horizon.eu/news-events/...
July 24, 2025 at 9:36 AM
🔬 Curious about the latest progress in gene therapy for muscular dystrophies?

The #MAGICproject is publishing impactful research, scientific tools & resources for the wider community.

🧬 Explore open-access papers, abstracts, and key findings here:
👉 magic-horizon.eu

#GeneTherapy #RareDisease
July 2, 2025 at 11:40 AM
🚨 New pre-print from the #MAGICproject!

Our team modelled L-CMD, a severe laminopathy, using iPSC-derived skeletal muscle & showed how precise CRISPR correction reverses nuclear defects, while exon-skipping doesn’t.

biorxiv.org/content/10.1...

#Laminopathy #GeneTherapy #iPSC
June 25, 2025 at 1:03 PM
🚨 New pre-print from the #MAGICproject!

We model L-CMD-a severe laminopathy-using iPSC-derived skeletal muscle & show how precise CRISPR correction reverses nuclear defects, while exon-skipping doesn’t.

www.biorxiv.org/content/10.1...
#Laminopathy #GeneTherapy #iPSC
June 24, 2025 at 9:04 AM
🔬 In the #MAGICproject, Prof. Karen English (@muresearch.bsky.social) is tackling immune reactions to AAV gene therapies for muscular dystrophy.

The goal: identify & calm early immune responses to boost safety & efficacy.

🔬 Full interview: magic-horizon.eu/news/meet-nu...

#GeneTherapy #AAV
June 19, 2025 at 10:18 AM
🚨 New publication from the #MAGICproject!

A novel iPSC line from a UCMD patient with a COL6A1 mutation offers a valuable new model for studying collagen VI-related muscular dystrophies and testing therapies.

📖 Read the paper: www.sciencedirect.com/science/arti...
June 11, 2025 at 11:06 AM
📫 Our next newsletter is landing in inboxes soon!

Subscribe to hear the latest updates from the #MAGICproject, such as:

🔬 Advances in genetic therapies for muscular dystrophies
📰 Conference and event highlights
📝 New research publications
…and more!

👉 Sign up: magic-horizon.eu/news-events/...
May 29, 2025 at 2:10 PM
From discovery to delivery, gene therapies must be scalable.

Siegfried DINAMIQS supports the #MAGICproject to tackle manufacturing early.

Eduard Ayuso: “...make groundbreaking therapies manufacturable at quality and cost for patients.”

🔗 magic-horizon.eu/news/meet-di...
May 22, 2025 at 8:12 AM