We're all struggling with this these days.

We use this strategy to assess the improvement in the Astral Zoom over the original. We also use this strategy to evaluate the effect of different acquisition strategies. Looking forward to seeing others apply this approach in the evaluation of other instruments. Great work by @chrhsu.bsky.social.

It's lossless in the sense that there is no loss in information in counting one ion at a time versus 10^4. When you have a large number of items one should never count them 1 at a time.

If those professors are anything like me they probably need the most teaching.

I would argue this is the same for most proteomics. There are definitely a lot of challenges with experimental design and I think the field in general struggles to understand and how to minimize confounders.

Maybe they mean multi-protein profiling?

Just saw it now back to back.