Justin Mabin
@mabinjw.bsky.social
Husband, Dad, and PhD.
RNA Biochemist/Bioinformatician in the Hogg lab at the NIH NHLBI, studying the effects of spliceosome dysfunction on the transcriptome.
RNA Biochemist/Bioinformatician in the Hogg lab at the NIH NHLBI, studying the effects of spliceosome dysfunction on the transcriptome.
Reposted by Justin Mabin
Uncovering the isoform-resolution kinetic landscape of nonsense-mediated mRNA decay with EZbakR https://www.biorxiv.org/content/10.1101/2025.03.12.642874v1
March 15, 2025 at 3:16 AM
Uncovering the isoform-resolution kinetic landscape of nonsense-mediated mRNA decay with EZbakR https://www.biorxiv.org/content/10.1101/2025.03.12.642874v1
Reposted by Justin Mabin
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
March 3, 2025 at 3:55 PM
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.