Lung-Yu Liang
@lungyul.bsky.social
Reposted by Lung-Yu Liang
It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...
December 16, 2025 at 8:17 AM
It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...
Reposted by Lung-Yu Liang
Did you know we’re hosting the EMBO Practical Course on Cryo-FIB & Cryo-ET in April 2026? ❄️ We invite early career researchers and facility scientists to join us in Frankfurt and meet the leading experts in cryo-FIB/SEM and cryo-ET!
🔗 Apply by Dec 8: meetings.embo.org/event/26-in-...
🔗 Apply by Dec 8: meetings.embo.org/event/26-in-...
December 2, 2025 at 9:32 AM
Did you know we’re hosting the EMBO Practical Course on Cryo-FIB & Cryo-ET in April 2026? ❄️ We invite early career researchers and facility scientists to join us in Frankfurt and meet the leading experts in cryo-FIB/SEM and cryo-ET!
🔗 Apply by Dec 8: meetings.embo.org/event/26-in-...
🔗 Apply by Dec 8: meetings.embo.org/event/26-in-...
Reposted by Lung-Yu Liang
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 5:42 PM
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
Reposted by Lung-Yu Liang
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)
Register now: bit.ly/4iXGqjw
Register now: bit.ly/4iXGqjw
October 17, 2025 at 6:29 AM
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)
Register now: bit.ly/4iXGqjw
Register now: bit.ly/4iXGqjw
Reposted by Lung-Yu Liang
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → [email protected]
Info about the group: www.embl.org/groups/dodon...
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → [email protected]
Info about the group: www.embl.org/groups/dodon...
Dodonova Group – Organisational principles and 3D architecture of archaeal chromatin
www.embl.org
October 15, 2025 at 10:38 AM
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → [email protected]
Info about the group: www.embl.org/groups/dodon...
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → [email protected]
Info about the group: www.embl.org/groups/dodon...
Reposted by Lung-Yu Liang
Fantastic new work from our researchers!
Check out their work on 🐯 cryoTIGER for cryoET 🐯
Check out their work on 🐯 cryoTIGER for cryoET 🐯
❓What if you could peek between your tilt series ❓ We are proud to introduce cryoTIGER -- deep-learning based tilt interpolation for enhanced reconstruction in cryo-ET. A great collaboration between Turoňová lab, @becklab.bsky.social, @hummerlab.bsky.social #teamtomo www.nature.com/articles/s42...
cryoTIGER: deep-learning based tilt interpolation generator for enhanced reconstruction in cryo electron tomography - Communications Biology
Deep learning-based interpolation using cryoTIGER enhances angular sampling in cryoET, improving 3D reconstructions, particle localization, and structural recovery without increasing electron dose.
www.nature.com
October 10, 2025 at 11:38 AM
Fantastic new work from our researchers!
Check out their work on 🐯 cryoTIGER for cryoET 🐯
Check out their work on 🐯 cryoTIGER for cryoET 🐯
Reposted by Lung-Yu Liang
We recently discovered a brand-new (and unique!) anti-phage defense system in bacteria. Check out this Pursuit article from @Melbourne University featuring our recent work. Terrific effort from our PhD student Somavally!
lnkd.in/geXUApmK
lnkd.in/geXUApmK
September 10, 2025 at 2:23 PM
We recently discovered a brand-new (and unique!) anti-phage defense system in bacteria. Check out this Pursuit article from @Melbourne University featuring our recent work. Terrific effort from our PhD student Somavally!
lnkd.in/geXUApmK
lnkd.in/geXUApmK
This is promised to be a great course!
We’re hosting the @embo.org Practical Course on In-situ structural biology by CryoFIB and CryoET in April 2026! 🧬❄️ You can expect hands-on training, cutting-edge methods, and a chance to work alongside leading experts in structural biology. 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...
August 20, 2025 at 6:19 PM
This is promised to be a great course!
Reposted by Lung-Yu Liang
Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗
🦟 Transgenic parasites without Pfs230 D13D14 do not transmit
🦙 💉Nanobodies + mRNA induced antibodies reduce transmission
New in @Science.org
www.science.org/doi/10.1126/...
#ScienceResearch #Malaria #WEHI
🦟 Transgenic parasites without Pfs230 D13D14 do not transmit
🦙 💉Nanobodies + mRNA induced antibodies reduce transmission
New in @Science.org
www.science.org/doi/10.1126/...
#ScienceResearch #Malaria #WEHI
August 1, 2025 at 12:58 AM
Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗
🦟 Transgenic parasites without Pfs230 D13D14 do not transmit
🦙 💉Nanobodies + mRNA induced antibodies reduce transmission
New in @Science.org
www.science.org/doi/10.1126/...
#ScienceResearch #Malaria #WEHI
🦟 Transgenic parasites without Pfs230 D13D14 do not transmit
🦙 💉Nanobodies + mRNA induced antibodies reduce transmission
New in @Science.org
www.science.org/doi/10.1126/...
#ScienceResearch #Malaria #WEHI
Reposted by Lung-Yu Liang
AI for Cryo-ET 🌟 Our new paper presents a deep-learning framework that cleans up faulty tilt series in a more automated, precise and powerful way! 💪 Read more here: www.sciencedirect.com/science/arti...
Automated removal of corrupted tilts in cryo-electron tomography
Cryo-electron tomography (cryo-ET) enables the visualization of macromolecular structures in their near-native cellular environment. However, acquired…
www.sciencedirect.com
July 25, 2025 at 10:14 AM
AI for Cryo-ET 🌟 Our new paper presents a deep-learning framework that cleans up faulty tilt series in a more automated, precise and powerful way! 💪 Read more here: www.sciencedirect.com/science/arti...
Reposted by Lung-Yu Liang
In their new study, Beata Turoňová and Tomáš Majtner trained 13 neural networks to automatically detect and remove those corrupted frames, speeding up processing and saving time for tomographers 🥳
July 25, 2025 at 10:14 AM
In their new study, Beata Turoňová and Tomáš Majtner trained 13 neural networks to automatically detect and remove those corrupted frames, speeding up processing and saving time for tomographers 🥳
Reposted by Lung-Yu Liang
New from my colleagues Markus Schreiber & Beata Turoňová: TANGO, an #opensource tool for more holistic spatial analysis of cryo-ET particles. It can clean or cluster particles, analyze lattices, and identify patterns. #TeamTomo
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Twist and Scout: Analysis and Curation of Particles in Cryo-Electron Tomography Using TANGO
Cryo-electron tomography (cryo-ET) enables the visualization of cellular structures in near-native environments, but its potential for spatial analysis has been underutilized due to a lack of versatil...
www.biorxiv.org
July 23, 2025 at 8:14 AM
New from my colleagues Markus Schreiber & Beata Turoňová: TANGO, an #opensource tool for more holistic spatial analysis of cryo-ET particles. It can clean or cluster particles, analyze lattices, and identify patterns. #TeamTomo
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Lung-Yu Liang
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
July 12, 2025 at 12:49 AM
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
Reposted by Lung-Yu Liang
This is Ana’s third ERC grant! We’re proud to celebrate her success and groundbreaking work here at the Max Planck Institute of Biophysics. #ERCAdG Read more here 🔗 www.biophys.mpg.de/2872321/garcia-saez-awarded-erc-grant
Ana García-Sáez Awarded Prestigious ERC Grant
www.biophys.mpg.de
June 17, 2025 at 12:17 PM
This is Ana’s third ERC grant! We’re proud to celebrate her success and groundbreaking work here at the Max Planck Institute of Biophysics. #ERCAdG Read more here 🔗 www.biophys.mpg.de/2872321/garcia-saez-awarded-erc-grant
Reposted by Lung-Yu Liang
(1/3) Together with the labs of Valerie Doye @vdoye.bsky.social and Hans-Georg-Kräusslich, we analyzed NPC structure in Nup133 null mESCs. We found heterogenous NPCs featuring non-canonical symmetries and missing subunits. Now online @naturecellbiology.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 11, 2025 at 1:26 PM
(1/3) Together with the labs of Valerie Doye @vdoye.bsky.social and Hans-Georg-Kräusslich, we analyzed NPC structure in Nup133 null mESCs. We found heterogenous NPCs featuring non-canonical symmetries and missing subunits. Now online @naturecellbiology.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lung-Yu Liang
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
April 11, 2025 at 9:04 AM
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
Reposted by Lung-Yu Liang
Delighted to share our recent work in Nat Comms. This is a "Story of a dwarf predator"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 29, 2025 at 1:26 PM
Delighted to share our recent work in Nat Comms. This is a "Story of a dwarf predator"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lung-Yu Liang
In situ evidence for systematic membrane thickness variation across cellular organelles https://www.biorxiv.org/content/10.1101/2025.03.13.642912v1
March 14, 2025 at 6:47 AM
In situ evidence for systematic membrane thickness variation across cellular organelles https://www.biorxiv.org/content/10.1101/2025.03.13.642912v1
Reposted by Lung-Yu Liang
Automated Removal of Corrupted Tilts in Cryo-Electron Tomography https://www.biorxiv.org/content/10.1101/2025.03.13.642992v1
March 15, 2025 at 7:17 AM
Automated Removal of Corrupted Tilts in Cryo-Electron Tomography https://www.biorxiv.org/content/10.1101/2025.03.13.642992v1
Congrats Natalia!
Excited to share that I have received a Marie Skłodowska-Curie Actions Postdoctoral Fellowship for my project SynLncRNAs! Looking forward to uncovering mechanisms of gene regulation by lncRNAs in vivo using synthetic biology in the Mundlos Lab @molgen.mpg.de 🧬
The 2024 Marie Skłodowska-Curie Actions Postdoctoral Fellowship call results are in.
With a budget of €417 million, we are funding nearly 1,700 researchers from 🇪🇺 and beyond.
They will strengthen EU research in key areas such as social inclusion, AI, and cancer research ↓
europa.eu/!BmWRkh
With a budget of €417 million, we are funding nearly 1,700 researchers from 🇪🇺 and beyond.
They will strengthen EU research in key areas such as social inclusion, AI, and cancer research ↓
europa.eu/!BmWRkh
February 17, 2025 at 7:56 AM
Congrats Natalia!
Reposted by Lung-Yu Liang
Great to see this out in print. Not only a nice review from Hanadi Hoblos but also a beautiful artwork of RHIMs by Hanadi on the cover
❄️♥️Our February issue is online♥️❄️
On the cover - how posttranslational modifications and intermolecular interactions of protein kinases allosterically regulate necrosome activation from @pseudokinase.bsky.social and colleagues.
Find this and the rest of the issue 👉 www.cell.com/trends/bioch...
On the cover - how posttranslational modifications and intermolecular interactions of protein kinases allosterically regulate necrosome activation from @pseudokinase.bsky.social and colleagues.
Find this and the rest of the issue 👉 www.cell.com/trends/bioch...
February 6, 2025 at 8:03 PM
Great to see this out in print. Not only a nice review from Hanadi Hoblos but also a beautiful artwork of RHIMs by Hanadi on the cover
Reposted by Lung-Yu Liang
Congrats, Max! And big thanks and congratulations to our coauthors at MPI for Marine Microbiology, Bremen, MPI-CBG in Dresden, and in-house at the MPI of Biophysics! It's been great working with you all! @mpimarinemicrobio.bsky.social, @mpicbg.bsky.social sky.social, @hummerlab.bsky.social
Exciting green news! 🦠 Do you know how certain microorganisms make a living by transforming CO2 into useful molecules? Check out our new work on the molecular choreography behind acetyl-CoA synthesis in the CODH/ACS protein complex. 👩🔬 🔗 www.biophys.mpg.de/2844976/micr...
January 31, 2025 at 4:18 PM
Congrats, Max! And big thanks and congratulations to our coauthors at MPI for Marine Microbiology, Bremen, MPI-CBG in Dresden, and in-house at the MPI of Biophysics! It's been great working with you all! @mpimarinemicrobio.bsky.social, @mpicbg.bsky.social sky.social, @hummerlab.bsky.social
Reposted by Lung-Yu Liang
So happy that my main PhD project on HIV-1 nuclear entry is now out in Cell. I want to especially thank my supervisor Martin @becklab.bsky.social and our amazing collaborators @maziarheidari.bsky.social from @hummerlab.bsky.social, Vojtech Zila from the Kräusslich lab and many others.
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
January 17, 2025 at 6:53 PM
So happy that my main PhD project on HIV-1 nuclear entry is now out in Cell. I want to especially thank my supervisor Martin @becklab.bsky.social and our amazing collaborators @maziarheidari.bsky.social from @hummerlab.bsky.social, Vojtech Zila from the Kräusslich lab and many others.