⚖️ I will also provide critical perspectives on some of the other ‘hyped’ metabolites that are claimed to have “anti-obesity” effects . . .

@cbmr.science

😱 I will present two ‘horror stories’, one on lactate and one on pyruvate (unpublished), illustrating major overlooked methodological problems in e.g. metabolic toletance tests used to assess glucose homeostasis. 3/4

@clemmensenc.bsky.social @zgerharthines.bsky.social

Then you should join the @easdnews.bsky.social Rising Star Symposium tomorrow (thursday) at 🕗 08.30-10.10 in📍London Hall (or online). 2/4

👉 Legacy effect
👉 Novel subtype of T2D
👉 MASLD screening in newly diagnosed T2D
👉T2D and cardiorenal comorbidities
👉 Stressors and MetS
👉 Psychosocial inequality and foot compl. in newly diagnosed T2D
👉 Sex diff. in vascular compl.
👉 How MetS contributes to global disease burden

Then join the epidemiology-focused short oral discussion session (Event A) today (Tuesday) from 12.00 – 13.00 at Station 03 in Hall C. It will include presentations on 👇 2/3

Take-home 📨: Thin people are battling their own biology. The forces they try to overcome to gain weight are similar, if not the same, to those that people with high BMIs fight when trying to lose weight 👉 illustrating that biology largely determines our body weight!

www.nature.com/articles/s41...

. . . . as discussed by myself, @zgerharthines.bsky.social and @clemmensenc.bsky.social in this open access paper from @cp-trendsendomet.bsky.social 7/8

www.cell.com/trends/endoc...

But there are also people that seem to eat more than they burn. The observation that certain individuals with constitutional thinness remain weight stable while seemingly eating more calories than they expend might be explained by increased loss of calories in the toilet 💩 6/8

But what might explain weight gain resistance in people with constitutional thinness? For some thin people,
enhanced satiety might play a role 🍔 For others, increased energy expenditure could be an answer 🔥 as suggested by
@johnspeakman4.bsky.social's group 5/8

www.cell.com/cell-metabol...

The numerous anecdotes and stories appearing in this network illustrate that:

1) Weight stigma hits both ends of the BMI spectrum!

2) People with thinness might also help us improve the treatment of other cardiometabolic diseases! 4/8

royalsocietypublishing.org/doi/10.1098/...

In 2020, I started building a network for people living with constitutional thinness. This group now has more than 600 members that report to live with a persistent and healthy form of thinness. 3/8

Building on work by Mélina Bailly et al., and myself and @clemmensenc.bsky.social, the article illustrates how constitutional thinness might hold the keys for better understanding obesity and finally unlocking its ‘The Gordian Knot’, i.e. preventing overweight. 2/8
annualreviews.org/content/jour...

In the Journal Club, we highlight potential uses, together with key limitations, of a novel mouse model for studying lactate biology. It is freely available. Take a look if you're into e.g. metabolite or exercise biology👇
physoc.onlinelibrary.wiley.com/doi/10.1113/...

We wrote one of these last year and I'm really happy to see the above recognition of our work which was led by @niclasrausch.bsky.social when he was visiting the @zgerharthines.bsky.social Lab at the @cbmr.science. 2/3