John Lukens
@lukensjohnr.bsky.social
Neuroimmunologist studying MS, autism, Alzheimer's disease, and brain injury at the University of Virginia. Father of two. Fan of Philly sports and US soccer.
www.lukenslab.com
www.lukenslab.com
Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity @cellpress.bsky.social www.cell.com/cell/fulltex...
November 26, 2025 at 3:49 PM
Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity @cellpress.bsky.social www.cell.com/cell/fulltex...
IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness: @cellpress.bsky.social www.cell.com/cell/fulltex...
November 25, 2025 at 3:41 PM
IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness: @cellpress.bsky.social www.cell.com/cell/fulltex...
Resolving the mysteries of brain clearance and immune surveillance: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
November 24, 2025 at 4:13 PM
Resolving the mysteries of brain clearance and immune surveillance: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo
alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social
November 21, 2025 at 2:24 PM
Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo
alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social
Astrocytic Sox9 overexpression in Alzheimer’s disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 21, 2025 at 1:39 PM
Astrocytic Sox9 overexpression in Alzheimer’s disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Elucidating pathway-selective biased CCKBR agonism for Alzheimer’s disease treatment @cellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
November 20, 2025 at 5:15 PM
Elucidating pathway-selective biased CCKBR agonism for Alzheimer’s disease treatment @cellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Therapeutic VEGFC treatment protects against traumatic brain injury-driven tauopathy pathogenesis @cp-cellreports.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
November 17, 2025 at 1:55 PM
Therapeutic VEGFC treatment protects against traumatic brain injury-driven tauopathy pathogenesis @cp-cellreports.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Lipid metabolism and neuroinflammation: What is the link? rupress.org/jem/article/...
August 6, 2025 at 1:40 PM
Lipid metabolism and neuroinflammation: What is the link? rupress.org/jem/article/...
Alzheimer’s disease transcriptional landscape in ex vivo human microglia www.nature.com/articles/s41...
August 4, 2025 at 1:54 PM
Alzheimer’s disease transcriptional landscape in ex vivo human microglia www.nature.com/articles/s41...
APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 16, 2025 at 1:45 PM
APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 14, 2025 at 3:46 PM
Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Taking the STING out of neurodegenerative disease url: rupress.org/jem/article/...
July 11, 2025 at 4:26 PM
Taking the STING out of neurodegenerative disease url: rupress.org/jem/article/...
Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal @science.org www.science.org/doi/10.1126/...
July 10, 2025 at 6:58 PM
Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal @science.org www.science.org/doi/10.1126/...
Microglial cGAS-STING-TBK1 activation in paraventricular thalamus mediates sleep and emotional disturbances in lupus mice www.sciencedirect.com/science/arti...
July 5, 2025 at 4:33 PM
Microglial cGAS-STING-TBK1 activation in paraventricular thalamus mediates sleep and emotional disturbances in lupus mice www.sciencedirect.com/science/arti...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...
June 23, 2025 at 8:07 PM
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...
Peripheral infection wires T cells in the brain
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 18, 2025 at 1:01 PM
Peripheral infection wires T cells in the brain
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo. @cp-immunity.bsky.social www.cell.com/immunity/ful...
June 16, 2025 at 2:33 PM
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo. @cp-immunity.bsky.social www.cell.com/immunity/ful...
Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 13, 2025 at 1:27 PM
Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Time is running out to register for the AAI Introductory Course in Immunology! Join me and other expert faculty in LA from July 8-13 to expand your knowledge of the immune system. I will be lecturing on neuroimmunology. @aai.org
www.aai.org/Education/Co...
www.aai.org/Education/Co...
June 9, 2025 at 9:13 PM
Time is running out to register for the AAI Introductory Course in Immunology! Join me and other expert faculty in LA from July 8-13 to expand your knowledge of the immune system. I will be lecturing on neuroimmunology. @aai.org
www.aai.org/Education/Co...
www.aai.org/Education/Co...
CLEC7A/Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis @cp-immunity.bsky.social www.cell.com/immunity/ful...
June 9, 2025 at 4:54 PM
CLEC7A/Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis @cp-immunity.bsky.social www.cell.com/immunity/ful...
Acute experimental colitis in 5xFAD Alzheimer's disease mice leads to enhanced monocyte infiltration into the brain accompanied by reduced β‐amyloid deposition alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
June 4, 2025 at 2:59 PM
Acute experimental colitis in 5xFAD Alzheimer's disease mice leads to enhanced monocyte infiltration into the brain accompanied by reduced β‐amyloid deposition alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
June 3, 2025 at 2:49 PM
Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis: @cp-immunity.bsky.social www.cell.com/immunity/ful...
May 30, 2025 at 3:38 PM
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis: @cp-immunity.bsky.social www.cell.com/immunity/ful...
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...
May 19, 2025 at 3:14 PM
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...
JCI - The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17 www.jci.org/articles/vie...
May 15, 2025 at 10:57 AM
JCI - The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17 www.jci.org/articles/vie...