Lukas
@lukasfeilen.bsky.social
Postdoctoral researcher in Autzen Lab at University of Copenhagen - Membrane protein structural biology
Reposted by Lukas
Our paper on the human carnitine transporter OCTN2 (SLC22A5) is out in @natcomms.nature.com! We solved structures of OCTN2 in multiple states and explored how carnitine transport is Na⁺-dependent, providing a framework for understanding SPCD disease causing variants and drug interactions.
Structural basis of sodium ion-dependent carnitine transport by OCTN2
Nature Communications - Carnitine uptake by OCTN2 supports fatty acid metabolism. Here, authors report cryo-EM structures of human OCTN2, revealing the mechanism of sodium ion-dependent carnitine...
rdcu.be
January 8, 2026 at 12:05 AM
Our paper on the human carnitine transporter OCTN2 (SLC22A5) is out in @natcomms.nature.com! We solved structures of OCTN2 in multiple states and explored how carnitine transport is Na⁺-dependent, providing a framework for understanding SPCD disease causing variants and drug interactions.
Reposted by Lukas
✨ Absolutely delighted to share that our paper, “MAASTY: a (dis)ordered copolymer for structural determination of human membrane proteins in native nanodiscs”, is now finally out! ✨
www.nature.com/articles/s41...
www.nature.com/articles/s41...
MAASTY: a (dis)ordered copolymer for structural determination of human membrane proteins in native nanodiscs - Nature Communications
MAASTY, a methacrylic acid–styrene copolymer, enables high-resolution structural determination of human membrane proteins in native nanodiscs, efficiently solubilizing diverse membrane proteins and pr...
www.nature.com
December 10, 2025 at 2:48 PM
✨ Absolutely delighted to share that our paper, “MAASTY: a (dis)ordered copolymer for structural determination of human membrane proteins in native nanodiscs”, is now finally out! ✨
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lukas
🚨 One week left to apply!
I am hiring a fully funded PhD fellow and a postdoc to work on membrane protein structural biology and pharmacology at Univ Copenhagen
Come work with a great team and exciting projects in a collaborative environment!
🔗 Links to the ads in comments
#CryoEM #AcademicJobs
I am hiring a fully funded PhD fellow and a postdoc to work on membrane protein structural biology and pharmacology at Univ Copenhagen
Come work with a great team and exciting projects in a collaborative environment!
🔗 Links to the ads in comments
#CryoEM #AcademicJobs
August 3, 2025 at 8:21 PM
🚨 One week left to apply!
I am hiring a fully funded PhD fellow and a postdoc to work on membrane protein structural biology and pharmacology at Univ Copenhagen
Come work with a great team and exciting projects in a collaborative environment!
🔗 Links to the ads in comments
#CryoEM #AcademicJobs
I am hiring a fully funded PhD fellow and a postdoc to work on membrane protein structural biology and pharmacology at Univ Copenhagen
Come work with a great team and exciting projects in a collaborative environment!
🔗 Links to the ads in comments
#CryoEM #AcademicJobs
Reposted by Lukas
I am excited to share our latest preprint presenting the structure of human NHE6, a key endosomal Na⁺/H⁺ exchanger involved in Christianson syndrome.
We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.
We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.
July 28, 2025 at 9:31 PM
I am excited to share our latest preprint presenting the structure of human NHE6, a key endosomal Na⁺/H⁺ exchanger involved in Christianson syndrome.
We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.
We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.
Reposted by Lukas
Beyond excited to present our study on the glycine transporter #GlyT2, a promising #non-opioid target for the treatment of neuropathic pain.
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
Structural insights into allosteric mechanism of glycine transporter-mediated analgesia
Chronic neuropathic pain, caused by nerve damage or disease, affects 10% of the population with rising incidence. The burden is exacerbated by ineffective treatments and overreliance on opioids. Neuro...
www.biorxiv.org
April 24, 2025 at 8:14 PM
Beyond excited to present our study on the glycine transporter #GlyT2, a promising #non-opioid target for the treatment of neuropathic pain.
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...