Lingjun Li Research Group
@liresearch.bsky.social
Student-run account for the Lingjun Li Lab at UW-Madison. #TeamMassSpec @uwmadpharmacy @uwmadisonchem
Pinned
TEMI: tissue-expansion mass-spectrometry imaging
Nature Methods - Tissue-expansion method compatible with mass-spectrometry imaging (TEMI) enables the profiling of lipids, metabolites, peptides, proteins, and N-glycans in complex tissues with...
rdcu.be
Exciting paper in @naturemethods.bsky.social that pushes the boundaries of MSI and spatially-resolved omics🥳🥳🥳TEMI reaches single-cell spatial resolution and enables the profiling of hundreds of lipids, metabolites, peptides, and N-glycans in complex tissue. Check it out: rdcu.be/eiIWy
Kicking off 2026 with great news 🎉🥳
Our work is featured as the Front Cover of ACS Central Science!
Big congrats to the team and special thanks to Sally Griffith-Oh for the stunning cover ✨
Check it out here:
pubs.acs.org/toc/acscii/1... pubs.acs.org/doi/10.1021/...
Our work is featured as the Front Cover of ACS Central Science!
Big congrats to the team and special thanks to Sally Griffith-Oh for the stunning cover ✨
Check it out here:
pubs.acs.org/toc/acscii/1... pubs.acs.org/doi/10.1021/...
January 28, 2026 at 9:04 PM
Kicking off 2026 with great news 🎉🥳
Our work is featured as the Front Cover of ACS Central Science!
Big congrats to the team and special thanks to Sally Griffith-Oh for the stunning cover ✨
Check it out here:
pubs.acs.org/toc/acscii/1... pubs.acs.org/doi/10.1021/...
Our work is featured as the Front Cover of ACS Central Science!
Big congrats to the team and special thanks to Sally Griffith-Oh for the stunning cover ✨
Check it out here:
pubs.acs.org/toc/acscii/1... pubs.acs.org/doi/10.1021/...
Congratulations to our PI @lingjun2025.bsky.social on her election as Treasurer on the ASMS Board of Directors 🥳
We look forward to her service as her term begins July 1, 2026. #[email protected] #ASMS2026
Check it out: lnkd.in/g_7XZzz5
We look forward to her service as her term begins July 1, 2026. #[email protected] #ASMS2026
Check it out: lnkd.in/g_7XZzz5
January 26, 2026 at 6:38 PM
Congratulations to our PI @lingjun2025.bsky.social on her election as Treasurer on the ASMS Board of Directors 🥳
We look forward to her service as her term begins July 1, 2026. #[email protected] #ASMS2026
Check it out: lnkd.in/g_7XZzz5
We look forward to her service as her term begins July 1, 2026. #[email protected] #ASMS2026
Check it out: lnkd.in/g_7XZzz5
Congrats to Julia on passing her Research Proposal exam and officially becoming a Ph.D. Candidate 🥳🥳🥳 Very well done 👏👏👏
January 17, 2026 at 12:48 AM
Congrats to Julia on passing her Research Proposal exam and officially becoming a Ph.D. Candidate 🥳🥳🥳 Very well done 👏👏👏
Our latest study on the first integrated structural proteomics (LiP-MS+FAIMS-DIA) and N-glycoproteomics analysis of paired serum and CSF samples across AD stages is now published in #ACSCentralScience 🥳🥳
Congrats to Haiyan and all co-authors🎊🎊
pubs.acs.org/doi/10.1021/...
Congrats to Haiyan and all co-authors🎊🎊
pubs.acs.org/doi/10.1021/...
Integrated Structural and Glycoproteomic Profiling Reveals Protein Conformational Remodeling and Biomarkers Across Alzheimer’s Disease Progression
Alzheimer’s disease (AD) is characterized by progressive neurodegeneration and protein misfolding, yet the structural dynamics of proteins and their post-translational modifications during disease pro...
pubs.acs.org
January 5, 2026 at 5:50 PM
Our latest study on the first integrated structural proteomics (LiP-MS+FAIMS-DIA) and N-glycoproteomics analysis of paired serum and CSF samples across AD stages is now published in #ACSCentralScience 🥳🥳
Congrats to Haiyan and all co-authors🎊🎊
pubs.acs.org/doi/10.1021/...
Congrats to Haiyan and all co-authors🎊🎊
pubs.acs.org/doi/10.1021/...
Happy New Year🎊 Our lab's first @pnas.org publication presents the first systems‑level map of how protein conformational changes and phosphorylation shape communication between pancreatic cancer and stellate cells🥳 Congrats to Haiyan and all co-authors👏
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 3, 2026 at 8:09 PM
Happy New Year🎊 Our lab's first @pnas.org publication presents the first systems‑level map of how protein conformational changes and phosphorylation shape communication between pancreatic cancer and stellate cells🥳 Congrats to Haiyan and all co-authors👏
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
We're thrilled to share #AnalyticalChemistry Supplementary Cover Art for our ant proteome work 🐜🐜 Special thanks to @uwmadpharmacy.bsky.social Sally Griffith-Oh for creating this beautiful cover art and thanks to everyone for this teamwork 🥳🥳@ACSPublications #MyACSCover
Link: doi.org/10.1021/acs....
Link: doi.org/10.1021/acs....
December 31, 2025 at 9:57 PM
We're thrilled to share #AnalyticalChemistry Supplementary Cover Art for our ant proteome work 🐜🐜 Special thanks to @uwmadpharmacy.bsky.social Sally Griffith-Oh for creating this beautiful cover art and thanks to everyone for this teamwork 🥳🥳@ACSPublications #MyACSCover
Link: doi.org/10.1021/acs....
Link: doi.org/10.1021/acs....
Congratulations to Emily on successfully passing her RP and achieving the dissertator status, an important milestone of her Ph.D. journey 🥳🥳 Can't wait to see her accomplishments in the next few years ✨✨
December 23, 2025 at 4:57 PM
Congratulations to Emily on successfully passing her RP and achieving the dissertator status, an important milestone of her Ph.D. journey 🥳🥳 Can't wait to see her accomplishments in the next few years ✨✨
Huge congratulations to our 74th Ph.D., Dr. Lauren Fields @chemistlauren.bsky.social 🍾🥂✨ Thank you for all the fun and outstanding mentorship you brought to our lab 😄 Wishing you all the best in your next postdoc chapter at Prof. Maccoss Lab 🥳 We will miss you so much!
December 18, 2025 at 4:54 PM
Huge congratulations to our 74th Ph.D., Dr. Lauren Fields @chemistlauren.bsky.social 🍾🥂✨ Thank you for all the fun and outstanding mentorship you brought to our lab 😄 Wishing you all the best in your next postdoc chapter at Prof. Maccoss Lab 🥳 We will miss you so much!
Reposted by Lingjun Li Research Group
Be sure to read in our latest issue research by Eric Troncy, @liresearch.bsky.social & co. from @uwmadison.bsky.social & @umontreal.ca revealing how osteoarthritis reshapes the spinal cord peptidome in rats #proteomics
Find the full article here🔽
Find the full article here🔽
Global spinal cord peptidome profiling in response to osteoarthritis in rats
Osteoarthritis (OA) is a complex and increasingly prevalent condition, affecting an estimated 600 million people worldwide and significantly reducing quality of life. Understanding OA as both an…
pubs.rsc.org
December 17, 2025 at 4:05 PM
Be sure to read in our latest issue research by Eric Troncy, @liresearch.bsky.social & co. from @uwmadison.bsky.social & @umontreal.ca revealing how osteoarthritis reshapes the spinal cord peptidome in rats #proteomics
Find the full article here🔽
Find the full article here🔽
Reposted by Lingjun Li Research Group
It's been a year of impact for Professor Lingjun Li (@liresearch.bsky.social): She became the first-ever School of Pharmacy recipient of UW–Madison’s Kellett Mid-Career Award, and now she's being honored with a 2026 Catherine Costello Award by @us-hupo.org! https://bit.ly/44xJChr
December 16, 2025 at 5:10 PM
It's been a year of impact for Professor Lingjun Li (@liresearch.bsky.social): She became the first-ever School of Pharmacy recipient of UW–Madison’s Kellett Mid-Career Award, and now she's being honored with a 2026 Catherine Costello Award by @us-hupo.org! https://bit.ly/44xJChr
Great food, loud laughs, and a spirited White Elephant exchange at the annual Li Lab holiday party 🎄🎁
Huge congratulations to our 74th Ph.D., Dr. Lauren Fields 👩🎓🍾
So excited to welcome 10 new members to the lab family 🥳🥳
Cheers to another successful year 🥂✨
Huge congratulations to our 74th Ph.D., Dr. Lauren Fields 👩🎓🍾
So excited to welcome 10 new members to the lab family 🥳🥳
Cheers to another successful year 🥂✨
December 16, 2025 at 12:59 PM
Great food, loud laughs, and a spirited White Elephant exchange at the annual Li Lab holiday party 🎄🎁
Huge congratulations to our 74th Ph.D., Dr. Lauren Fields 👩🎓🍾
So excited to welcome 10 new members to the lab family 🥳🥳
Cheers to another successful year 🥂✨
Huge congratulations to our 74th Ph.D., Dr. Lauren Fields 👩🎓🍾
So excited to welcome 10 new members to the lab family 🥳🥳
Cheers to another successful year 🥂✨
New publication in Analytical Chemistry, in collab with Cameron Currie Lab 🥳 A dual-layered proteomic workflow that maps both whole-body and surface-secreted proteins in the leaf-cutter ant Acromyrmex echinatior. Huge congrats to Timo, Haiyan, and all co-authors 👏👏
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Proteome-Wide Analysis and Surface Protein Isolation for Secretome Characterization Reveal Insights into the Biology of the Leaf-Cutter Ant Acromyrmex echinatior
Characterizing the proteome of an organism can provide critical insights into the proteins that regulate key biological processes such as development, physiology, and environmental interactions. While...
pubs.acs.org
December 12, 2025 at 8:03 PM
New publication in Analytical Chemistry, in collab with Cameron Currie Lab 🥳 A dual-layered proteomic workflow that maps both whole-body and surface-secreted proteins in the leaf-cutter ant Acromyrmex echinatior. Huge congrats to Timo, Haiyan, and all co-authors 👏👏
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
New publication on Anal Chem 🥳🥳 Our new 3-plex TMTproC-DIA strategy delivers accurate multiplexed quantification, high precision even in complex sample backgrounds without adding spectral complexity. Congrats to Zicong, @pk-liu.bsky.social, and Haiyan 👏👏
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Multiplexed Data-Independent Acquisition-Based Proteomics Enabled by TMTpro Complementary Ions
Data-independent acquisition (DIA) has emerged as a powerful approach in quantitative proteomics, offering more comprehensive and reproducible proteome coverage than the conventional data-dependent ac...
pubs.acs.org
December 3, 2025 at 1:54 PM
New publication on Anal Chem 🥳🥳 Our new 3-plex TMTproC-DIA strategy delivers accurate multiplexed quantification, high precision even in complex sample backgrounds without adding spectral complexity. Congrats to Zicong, @pk-liu.bsky.social, and Haiyan 👏👏
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Congratulations to Graham (Jiahao) on successfully passing his prelim exam with flying colors 🥳🥳 Can't wait to see what he can accomplish with this exciting project in the coming years 🤓🤓
November 25, 2025 at 9:25 PM
Congratulations to Graham (Jiahao) on successfully passing his prelim exam with flying colors 🥳🥳 Can't wait to see what he can accomplish with this exciting project in the coming years 🤓🤓
Li Lab Friendsgiving Party ✨
A night filled with gratitude, homemade goodness, endless laughs, and the best lab family we could ask for 🍽️🧡
Sending our warmest congratulations to Dr. Hua Zhang as he embarks on his exciting new professorship journey 🥳🥳🥳
A night filled with gratitude, homemade goodness, endless laughs, and the best lab family we could ask for 🍽️🧡
Sending our warmest congratulations to Dr. Hua Zhang as he embarks on his exciting new professorship journey 🥳🥳🥳
November 23, 2025 at 7:59 PM
Li Lab Friendsgiving Party ✨
A night filled with gratitude, homemade goodness, endless laughs, and the best lab family we could ask for 🍽️🧡
Sending our warmest congratulations to Dr. Hua Zhang as he embarks on his exciting new professorship journey 🥳🥳🥳
A night filled with gratitude, homemade goodness, endless laughs, and the best lab family we could ask for 🍽️🧡
Sending our warmest congratulations to Dr. Hua Zhang as he embarks on his exciting new professorship journey 🥳🥳🥳
Our new review paper on ACA Special Issue of Imaging Mass Spec 🥳🥳 We highlight recent advances in single-cell MSI, focusing on improved spatial resolution, molecular coverage, and analytical workflows. Congrats to Hua and co-authors 👏👏
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Single-cell mass spectrometry imaging: emerging advancements and future insights
Single-cell mass spectrometry imaging (MSI) has emerged as a transformative technology for dissecting complex biological systems with high spatial pre…
www.sciencedirect.com
November 4, 2025 at 4:49 PM
Our new review paper on ACA Special Issue of Imaging Mass Spec 🥳🥳 We highlight recent advances in single-cell MSI, focusing on improved spatial resolution, molecular coverage, and analytical workflows. Congrats to Hua and co-authors 👏👏
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Costumes, candy, and chemistry 🧪🎃 Li lab turned spooky for a day 👻
November 1, 2025 at 12:19 AM
Costumes, candy, and chemistry 🧪🎃 Li lab turned spooky for a day 👻
New publication on @molecularomics.rsc.org 🥳Our work revealed how osteoarthritis reshapes the neuropeptide landscape of the spinal cord in the MIRAT model. This is a nice collaboration with Prof. Eric Troncy Lab, and congrats to Gaoyuan, Marilyn and all co-authors 👏
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Global spinal cord peptidome profiling in response to osteoarthritis in rats
Osteoarthritis (OA) is a complex and increasingly prevalent condition, affecting an estimated 600 million people worldwide and significantly reducing quality of life. Understanding OA as both an infla...
pubs.rsc.org
October 29, 2025 at 5:55 PM
New publication on @molecularomics.rsc.org 🥳Our work revealed how osteoarthritis reshapes the neuropeptide landscape of the spinal cord in the MIRAT model. This is a nice collaboration with Prof. Eric Troncy Lab, and congrats to Gaoyuan, Marilyn and all co-authors 👏
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Reposted by Lingjun Li Research Group
Congratulations to Prof. Lingjun Li (@liresearch.bsky.social) on earning a @uwmadison.bsky.social Kellett Mid-Career Award to support her "high risk, high reward" work in single-cell analysis & #massspectrometry, geared to understand tumors & neuron communication! pharmacy.wisc.edu/2025/09/10/p...
October 23, 2025 at 4:07 PM
Congratulations to Prof. Lingjun Li (@liresearch.bsky.social) on earning a @uwmadison.bsky.social Kellett Mid-Career Award to support her "high risk, high reward" work in single-cell analysis & #massspectrometry, geared to understand tumors & neuron communication! pharmacy.wisc.edu/2025/09/10/p...
Fall tradition continues 🍂🍁 The Li Lab returned to Eugster’s Farm for another day of apple picking, pumpkin hunting, and apple cider donut 🍎🎃🍩 Grateful for great weather and great company with our rotation students 🥳🥳
October 19, 2025 at 2:44 PM
Fall tradition continues 🍂🍁 The Li Lab returned to Eugster’s Farm for another day of apple picking, pumpkin hunting, and apple cider donut 🍎🎃🍩 Grateful for great weather and great company with our rotation students 🥳🥳
Reposted by Lingjun Li Research Group
🚨 A new study from Professor Lingjun Li @liresearch.bsky.social and collaborators in the Molecular Psychiatry journal finds that changes in an enzyme that helps #neurons function properly can alter synaptic function and drive #autism-like behaviors in a model.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Increased expression of ATase1/NAT8B or ATase2/NAT8 in the mouse results in an autistic-like phenotype with altered dendritic branching and spine formation - Molecular Psychiatry
Molecular Psychiatry - Increased expression of ATase1/NAT8B or ATase2/NAT8 in the mouse results in an autistic-like phenotype with altered dendritic branching and spine formation
www.nature.com
October 10, 2025 at 4:18 PM
🚨 A new study from Professor Lingjun Li @liresearch.bsky.social and collaborators in the Molecular Psychiatry journal finds that changes in an enzyme that helps #neurons function properly can alter synaptic function and drive #autism-like behaviors in a model.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Jeopardy night, round 3 🎉 Another year of laughter, surprises, and impressive fun facts from our lab crew 😆 Always a highlight seeing everyone’s hidden talents (and competitive side) ✨ Shoutout to Lauren, Jacey, and Kelly for organizing all the fun 👏
October 8, 2025 at 12:57 PM
Jeopardy night, round 3 🎉 Another year of laughter, surprises, and impressive fun facts from our lab crew 😆 Always a highlight seeing everyone’s hidden talents (and competitive side) ✨ Shoutout to Lauren, Jacey, and Kelly for organizing all the fun 👏
Excited to share our latest work on Analytical Chemistry, introducing a novel 13-plex DeAla isobaric tag for improved peptide fragmentation, enhanced protein identification, and competitive pricing 🥳🥳🥳 Congrats to @pk-liu.bsky.social and co-authors ✨✨
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
13-Plex DeAla Isobaric Reagents for High-Throughput Proteome Quantification
Isobaric labeling techniques are widely used in mass spectrometry-based quantitative proteomics to enable the simultaneous analysis of multiple samples. However, commercial isobaric tags are expensive...
pubs.acs.org
October 7, 2025 at 3:22 PM
Excited to share our latest work on Analytical Chemistry, introducing a novel 13-plex DeAla isobaric tag for improved peptide fragmentation, enhanced protein identification, and competitive pricing 🥳🥳🥳 Congrats to @pk-liu.bsky.social and co-authors ✨✨
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
New publication on Analytica Chimica Acta 🥳🥳 We presented 3D spatial proteomic and lipidomic analysis of AD and WT mouse brains via 10-plex immunohistochemistry (IHC)-based photocleavable mass tag (PC-MT) labeling. Congrats Kelly and co-authors 👏👏
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Deciphering the Three-Dimensional Biomolecular Distribution in the Alzheimer’s Disease Brain: A Multiomic Approach Integrating Immunohistochemistry with MALDI MS Imaging
Alzheimer’s disease (AD) is characterized by complex and distinct spatial and molecular changes in the brain that contribute to its onset and progress…
www.sciencedirect.com
October 3, 2025 at 7:07 PM
New publication on Analytica Chimica Acta 🥳🥳 We presented 3D spatial proteomic and lipidomic analysis of AD and WT mouse brains via 10-plex immunohistochemistry (IHC)-based photocleavable mass tag (PC-MT) labeling. Congrats Kelly and co-authors 👏👏
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Celebrating the successful 3rd International Single Cell Mass Spec conference in Chicago last weekend🥳 Congrats to Kelly for winning Best Poster Award and Hua for Young Investigator Award in the category of best advancement award recognizing his scientific accomplishments👏
September 30, 2025 at 1:13 PM
Celebrating the successful 3rd International Single Cell Mass Spec conference in Chicago last weekend🥳 Congrats to Kelly for winning Best Poster Award and Hua for Young Investigator Award in the category of best advancement award recognizing his scientific accomplishments👏